Projects & Grants

Determination of correlation between transcranial utrasound and magnetic resonance findings and histopathological findings in Parkinsons disease.
Project IdSGS18/LF/2023
Main solverMgr. Patricie MICHALČOVÁ
Period1/2023 - 12/2023
ProviderSpecifický VŠ výzkum
AnotationParkinson's disease (PN) is the second most common neurodegenerative disease. Despite the fact that non-motor symptoms of the disease can already be observed in the prodromal phase, the diagnosis of PN is often established only when amount of dopaminergic neurons decrease to 40% or less, when the first motor symptoms begin to appear. The diagnosis of PN is primarily based on the detection of clinical symptoms, and the overall procedure for establishing the diagnosis is a long process. Therefore, there is a need to establish new diagnostic criteria for neuroimaging methods that will increase the chance of detecting PN already in the prodromal phase. Detection and localization of pathological signs in the brain of patients with PN on magnetic resonance (MR) and transcranial ultrasound (TCS) and subsequent image fusion are important to understand the relations between the findings in these modalities. The research results could shed light on the nature of the hyperechoic area found on the TCS, which has not been clarified since the year of the first finding. In the second phase of the study, these findings will be used to examine the correlation with histopathological findings on cadavers.