Research at the Institute of Molecular and Clinical Pathology and Medical Genetics

Institutional support no. 12 RVO-FNOs/2017: The importance of tumor heterogeneity in colorectal adenocarcinoma, principal investigator: MUDr. Mária Wozniaková (2017 – 2020)
Institutional support no. 24 RVO-FNOs/2017: The contribution of a modified method of processing liquid cytological material to improving the quality of diagnostics and better yield, principal investigator: Mgr. Jana Vaculová, Ph.D. (2017 - 2020)
Institutional support no. 14 RVO-FNOs/2018: Prognostic and predictive factors of perineural invasion of head and neck squamous cell carcinoma (HNSCC), principal investigator: MUDr. Marie Sporková, co-investigator: MUDr. Pavel Hurník, Ph.D. (2018 - 2021)
Institutional support no. 10 RVO-FNOs/2018: Molecular resection margins in squamous cell carcinomas of the orofacial region, principal investigator: doc. MUDr. Jan Štembírek, Ph.D., co-investigator: MUDr. Pavel Hurník, Ph.D. (2018 - 2021)
Institutional support 07/RVO-FNOs/2019: Identification of risk factors for recurrent respiratory papillomatosis and changes in the cell cycle and local immune response influenced by them, co-investigator MUDr. Pavel Hurník, Ph.D. (2019 - 2022)
AZV - NV19-08-00383 panel no.P08 /2019: Prognostic and predictive markers of invasion of squamous cell carcinomas of the oral cavity and oropharynx, co-investigator MUDr. Pavel Hurník, Ph.D. (principal investigator: Institute of Life Physiology and Genetics of the Academy of Sciences of the Czech Republic, v.v.i.)
AZV – NU20-08-00205 panel no. P08/2020: Molecular etiopathogenesis of apical periodontitis and odontogenic cysts, external collaboration: MUDr. Pavel Hurník, Ph.D. (principal investigator: Masaryk University/Faculty of Medicine)
AZV – NU20-06-00489 panel no. P06/2020: New methods of analysis of processes involved in the development of dental ankylosis, co-investigator MUDr. Pavel Hurník, Ph.D. (principal investigator: Institute of Life Physiology and Genetics of the Academy of Sciences of the Czech Republic, v.v.i.)
Institutional support 17/RVO-FNOs/2020: New prognostic and predictive markers in prostate cancer, principal investigator: Mgr. Tereza Hulínová (2020 – 2023)
Institutional support 24/RVO-FNOs/2020: L1CAM as a negative prognostic factor in early stages of cervical cancer, co-investigator: MUDr. Vladimír Židlík (2020 – 2023)
Institutional support 02/RVO-FNOs/2020: Use of multiparametric MRI in the diagnosis of muscle-infiltrating bladder cancer, co-investigator: MUDr. Vladimír Židlík (2020 – 2023)
IP 2/RVO-FNOs/2021: Creation of a workflow for real-time three-dimensional navigation using augmented reality in liver surgery, co-investigator: doc. MUDr. MVDr. Jozef Škarda, Ph.D., PhD., MUDr. Vladimír Židlík (principal investigator: MUDr. Jan Roman)
Project CZ.02.1.01/0.0/0.0/17_049/0008441: Innovative treatment methods of the musculoskeletal system in trauma surgery, co-investigator Mgr. Hana Bielniková, MUDr. Vladimír Židlík (supported within the framework of the Operational Program Research, Development and Education, call number 02_17_049 - Long-term intersectoral cooperation for ITI (cooperation between TU VŠB, FNO and LF OU 2019 - 2022)
Institutional support 08/RVO-FNOs/2021-23: Use of histotopogram in mesorectal lymph nodes in patients with rectal cancer in correlation with magnetic resonance imaging results, principal investigator: doc. MUDr. MVDr. Jozef Škarda, Ph.D., PhD.
Institutional support 09//RVO-FNOs/2021-23: New prognostic markers EZH2 and H3K27me3 and their relationship to immune system checkpoints PD-L1 in metastatic melanoma, principal investigator: MUDr. Vladimír Židlík
Institutional support 16//RVO-FNOs/2021-23: Presence of plastic particles in amniotic fluid and placenta in patients with premature premature rupture of amniotic fluid, co-investigator: MUDr. Patricie Delongová
Institutional support 27//RVO-FNOs/2021-23: Influence of immune response and radiomics on oncosurgical therapy of oral squamous cell carcinoma, collaborator: MUDr. Pavel Hurník, Ph.D.
07/RVO-FNOs/2022: Validation of biomarkers in aggressive forms of oral squamous cell carcinoma, principal investigator: principal investigator: doc. MUDr. Jan Štembírek, Ph.D.,co-investigator: MUDr. Pavel Hurník, Ph.D.
11/RVO-FNOs/2022: Molecular genetic predictors in radiosurgery of meningiomas, principal investigator: MUDr. Martin Palička, co-investigator: Mária Wozniaková
13/RVO-FNOs/2022: Analysis of cellular and molecular changes in salivary gland tumors, principal investigator: MUDr. Lucia Staníková, Ph.D., co-investigator: MUDr. Pavel Hurník, Ph.D.
15/RVO-FNOs/2022: L1CAM and HPV as prognostic factors in vulvar carcinoma, principal investigator: MUDr. Bc. Martina Romanová, co-investigator: MUDr. Vladimír Židlík
05/RVO-FNOs/2023: Potential diagnostic and prognostic significance of selected genetic alterations in the pathophysiology of glioblastoma, principal investigator: MUDr. Silvia Tomoszková, co-investigator: doc. MUDr. MVDr. Jozef Škarda, Ph.D., PhD.
25/RVO-FNOs/2023: Correlation of FOXP3+ T regulatory lymphocytes and IDO+ tumor cells from primary and metastatic melanoma, principal investigator: MUDr. Vladimír Židlík, co-investigator: MUDr. Pavel Hurník, Ph.D.
TAČR TREND Trend 6 / TAČR "SMART tables for medical applications" on assignment to a project in the ISTA application (SISTA), principal investigator: doc. MUDr. MVDr. Jozef Škarda, Ph.D., PhD.
NU23-05-00095/2023-2026: Early diagnosis of invasive pulmonary aspergillosis of the next generation, principal investigator: doc. MUDr. MVDr. Jozef Škarda, Ph.D., PhD., (Faculty Hospital Ostrava), co-investigators: Mgr. Radim Dobiáš, Ph. D, (Health Institute based in Ostrava) prof. Mgr. MUDr. Milan Raška, Ph.D, (Faculty Hospital Olomouc), prof. Ing. Vladimír Havlíček, Dr., (Institute of Microbiology of the Academy of Sciences of the Czech Republic, v.v.i.), Mgr. Lenka Kramná, Ph.D. (University of Ostrava)
Institutional support IP 17/RVO-FNOs/2024-2027: RAD51 as a prognostic factor in prostate cancer radiotherapy, investigator: doc. MUDr. MVDr. Jozef Škarda, Ph.D., PhD., collaborators: MUDr. Pavel Hurník, Ph.D.
Institutional support IP 10/RVO-FNOs/2024-2027: Typing of amyloid in various biological matrices using mass spectrometry, co-investigator: MUDr. Vladimír Židlík
Institutional support IP 07/RVO-FNOs/2024: Interaction of osteosynthetic material with the organism, investigator: MUDr. Jiří Voves, collaborators: MUDr. Szotkovská, Mgr. Kryštofová
AZV - NW24-10-00204: Evaluation of clinical, radiological and genetic characteristics in patients with orofacial anomalies in correlation with oncological diseases - an algorithm for improving diagnostics, principal investigator: doc. Buchtová, MUDr. Pavel Hurník, Ph.D.

Other areas of scientific research activity:

  • The role of von Willebrand factor and rADAMTS13 in mechanical thrombectomy procedure for acute ischemic stroke therapy
  • Prognostic value of tumor-infiltrating lymphocytes (TILs) and their association with PD-L1 expression and DNA repair protein RAD51 in patients with resectednon-small cell lung
  • DNA damage response associated kinases in solid tumors
  • LC3A positive „stone like“ structures (SLSs) are differentially associated with survival outcomes and tumor infiltrating lymphocytes in lung adenocarcinoma and squamous cell carcinoma
  • Major DNArepair proteins ATM and RAD51 are associated with autophagy activity in patients with non-small-cell lung carcinoma
  • The prognostic value of ATM protein loss in patients with non-small-cell lung cancer

Updated: 15. 04. 2025