Projects & Grants
| Analysis of the impact of formaldehyde fixation on atherosclerotic plaque imaging using dual-energy and photon-counting micro-CT | |
|---|---|
| Project Id | SGS22/LF/2026 |
| Main solver | Mgr. Anna VYBÍRALOVÁ |
| Period | 1/2026 - 12/2026 |
| Provider | Specifický VŠ výzkum |
| State | solved |
| Anotation | The research project focuses on a detailed analysis of atherosclerotic plaques of the internal carotid artery using advanced dual-energy and photon-counting micro-CT imaging techniques. The aim of the study is to compare the imaging of atherosclerotic plaque structures in freshly excised samples and in the same samples after three months of formaldehyde fixation, and to relate these findings to the patients? preoperative CTA scans. In the first phase, plaque specimens obtained during carotid endarterectomy will be scanned immediately after excision using both micro-CT modalities. The samples will then be stored in formaldehyde for three months, after which a second micro-CT examination will be performed. By comparing the results from both time points with preoperative CTA data, the study will assess how formaldehyde fixation affects the morphology and imaging characteristics of individual plaque components, such as calcifications, lipid cores, and fibrotic structures. The findings of this study are expected to provide a deeper understanding of the effects of fixation on the microstructure of vascular lesions and to contribute to the optimization of micro-CT imaging protocols for atherosclerosis research, particularly in correlation with clinical CTA. |
| Total Costs | 499 400 CZK |
