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Roman Hájek

Projects

Academic degree, name, surname:

prof. MUDr. Roman Hájek, CSc.

Room, floor, building:

R 204, Building R

Position:

Head of Department

Research interests and teaching:

Department (Faculty):

Department of Haematooncology (Faculty of Medicine)
Medical Research Center (Faculty of Medicine)

Phone number, mobile:

+420 553 46 1013
+420 597 372 091

E-mail:

Another education, courses

2006

Prof. - Masaryk University, Brno, Czech Republic; Field of Study: Clinical Oncology

2001

Assoc Prof. - Department of Internal Medicine and Hemato-oncology, Masaryk University Hospital Brno, Czech Republic; Field of Study: Internal Medicine

1995

Ph.D. - Department of Internal Medicine and Hemato-oncology, Masaryk University Hospital Brno, Czech Republic; Field of Study: Hematooncology

1988

M.D. - Masaryk University, Brno, Czech Republic; Field of Study: General Medicine

Working Practice

Since 2015

Vice-Rector for Strategy and Development; University of Ostrava, Czech Republic

Since 2012

Head of Department of Clinical Hematooncology; University Hospital Ostrava, Czech Republic

2012 – 2014

Vice-dean for Science and Research; Faculty of Medicine, Ostrava University, Czech Republic

2011 – 2015

Project manager of Babak Myeloma Group; Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic

2010 – 2011

Director of Babak Research Institute; Department of Pathological Physiology, Faculty of Medicine, Masaryk University, Brno, Czech Republic

2007 – 2012

Vice-Director for Education and Research; University Hospital Brno, Brno, Czech Republic

Since 1999

Head of Laboratory of Experimental Hematology and Cell Immunotherapy; University Hospital Brno, Brno, Czech Republic

1989 – 2012

Physician; Department of Internal Medicine Hematooncology, University Hospital Brno, Brno, Czech Republic

Valuation

IMF Brian D. Novis research grant funded through the Black Swan Research Initiative

Membership

Since 2012

International Myeloma Society

Since 2009

European Hematology Association

Since 2008

International Myeloma Working Group

Since 2008

American Society of Hematology

Since 2007

Scientific Advisory Board of the International Myeloma Foundation

Since 2007

European Myeloma Network (Member of the Board since 2019)

Since 2005

Medical Advisory Board of Myeloma Euronet

Since 2001

Czech Myeloma Group Foundation, Chairman

Since 1996

Czech Myeloma Group, Chairman

Since 1994

Czech Society of Hematology and Oncology (Head of Myeloma Committee since 2006)

Research and professional experience

2001

Royal Prince Alfred Hospital of Hematooncology - Sydney, Austrálie

1998

Arkansas Myeloma Research Center, USA

1997

Arkansas Myeloma Research Center, USA

1996

ESO course Molecular Biology for Clinicians; Cambridge, United Kingdom

1995

Georgetown University Medical Center, WA, D. C., USA

Beyond the marrow: insights from comprehensive nextgeneration sequencing of extramedullary multiple myeloma tumors

Tomáš Jelínek, David ŽIHALA, Tereza Ševčíková, Anjana Anilkumar Sithara, Veronika Kapustová, Hana Šahinbegović, Ondřej Venglář, Ludmila MUROŇOVÁ, Lucie Broskevičová, Serafim Nenarokov, Daniel Bílek, Tereza Popková, H. Plonková, Jan VRÁNA, Vladimír Židlík, Pavel Hurník, Martin Havel, Matouš Hrdinka, Zuzana Chyra, G. Stracquadanio, Michal Šimíček, Roman Hájek ... other authors

Year: 2024, Leukemia

journal article

Immunoablative therapy followed by autologous hematopoietic stem cell transplantation as the first-line disease-modifying therapy in patients with multiple sclerosis

Martin Lachnit, Kamila Žondra Revendová, Pavel Hradílek, Radovan Bunganič, Zdeněk Kořístek, Tomáš Jelínek, Monika Skutova, Radim Piza, Ondřej Volný, Roman Hájek, Michal Bar ... other authors

Year: 2024, BIOMEDICAL PAPERS-OLOMOUC

journal article

An economic evaluation of the effectiveness of telemedicine in hematooncology

M. Lebiedzik, K. Turečkova, I. Majerova, J. Nevima, Katarína Hradská, Tereza Popková, Michaela Skořupová, Roman Hájek ... other authors

Year: 2023, PLoS ONE

journal article

Benefit Versus Risk Assessment of Melflufen and Dexamethasone in Relapsed/Refractory Multiple Myeloma: Analyses From Longer Follow-up of the OCEAN and HORIZON Studies

Pieter Sonneveld, Paul G. Richardson, Heinz Ludwig, Meletios-Athanasios Dimopoulos, Fredrik H. Schjesvold, Roman Hájek, Haifaa Abdulhaq, Marcus Thuresson, Stefan Norin, Nicolaas A. Bakker, Maria-Victoria Mateos ... other authors

Year: 2023, Clinical Lymphoma, Myeloma and Leukemia

journal article

Bortezomib-Dexamethasone, Rituximab, and Cyclophosphamide as First-Line Treatment for Waldenstrom's Macroglobulinemia: A Prospectively Randomized Trial of the European Consortium for Waldenstrom's Macroglobulinemia

Christian Buske, Meletios A. Dimopoulos, Alexander Grunenberg, Efstathios Kastritis, Cecile Tomowiak, Beatrice Mahe, Xavier Troussard, Roman Hájek, Andreas Viardot, Olivier Tournilhac, Therese Aurran, Stephane Lepretre, Hacene Zerazhi, Benedicte Hivert, Veronique Leblond, Sophie de Guibert, Lena Brandefors, Ramon Garcia-Sanz, Maria Gomes da Silva, Eva Kimby, Birgit Schmelzle, Dajana Kaszynski, Jens Dreyhaupt, Rainer Muche, Pierre Morel ... other authors

Year: 2023, JOURNAL OF CLINICAL ONCOLOGY

journal article

Daratumumab with lenalidomide and dexamethasone in relapsed or refractory multiple myeloma patients - real world evidence analysis

Martin Stork, Ivan Spicka, Jakub Radocha, Jiri Minarik, Tomáš Jelínek, Alexandra Jungova, Petr Pavlicek, Lenka Pospisilova, Frantisek Sedlak, Jan Straub, Tomas Pika, Zdenka Knechtova, Anna Fidrichova, Ivanna Boichuk, Sabina Sevcikova, Vladimir Maisnar, Roman Hájek, Ludek Pour ... other authors

Year: 2023, ANNALS OF HEMATOLOGY

journal article

Diagnostika a léčba mnohočetného myelomu

Roman Hájek, Vladimír Maisnar, Jiří Minařík, Martin Štork, Tomáš Jelínek, Jakub Radocha, Alexandra Jungová, Marta Krejčí, Tereza Popková, Jan Straub, Zdeněk Adam, Marie Jarošová, Petr Kessler, Luděk Pour, Viera Sandecká, Eva Skácelíková, Ondřej Souček, Pavla Straubová, Michal Sýkora, Tereza Ševčíková, Ivan Špička, Emília Flochová, Lubica Harvanová, Juliana Holasová, Miriam Ladická, Natália Štecová ... other authors

Year: 2023, Transfuze a hematologie dnes

journal article

Effectiveness of tixagevimab/cilgavimab in patients with hematological malignancies as a pre-exposure prophylaxis to prevent severe COVID-19: a Czech retrospective multicenter study

Ivo Demel, David Skopal, Eliska Safrankova, Petra Rozsivalova, Pavel Jindra, Jiri Sramek, Adela Turkova, Jan Vydra, Klara Labska, Jana Vedrova, Martin Cernan, Tomas Szotkowski, Heidi Mocikova, Lenka Hynkova, Ondrej Šušol, Ingrid Kovacova, David Belada, Roman Hájek ... other authors

Year: 2023, ANNALS OF HEMATOLOGY

journal article

Identification of disease-related aberrantly spliced transcripts in myeloma and strategies to target these alterations by RNA-based therapeutics

Daisuke Ogiya, Zuzana Chyra, Sigitas J. Verselis, Morgan OKeefe, Jacquelyn Cobb, Ivane Abiatari, Srikanth Talluri, Anjana Anilkumar Sithara, Teru Hideshima, Michael P. P. Chu, Roman Hájek, David M. Dorfman, Linda M. Pilarski, Kenneth C. Anderson, Sophia Adamia ... other authors

Year: 2023, BLOOD CANCER JOURNAL

journal article

Insight into the mechanism of CD34+ cell mobilisation impairment in multiple myeloma patients treated with anti-CD38 therapy

Ondřej Venglář, Veronika Kapustová, Anjana Anilkumar Sithara, David ŽIHALA, Ludmila MUROŇOVÁ, Tereza Ševčíková, Jan Vrana, Alexander Vdovin, Jakub Radocha, Petra Krhovska, Matouš Hrdinka, Michal Turjap, Tereza Popková, Zuzana Chyra, Lucie Broskevičová, Michal Šimíček, Zdeněk Kořístek, Roman Hájek, Tomáš Jelínek ... other authors

Year: 2023, BRITISH JOURNAL OF HAEMATOLOGY

journal article

Isatuximab, carfilzomib, and dexamethasone in patients with relapsed multiple myeloma: updated results from IKEMA, a randomized Phase 3 study

Thomas Martin, Meletios-Athanasios Dimopoulos, Joseph Mikhael, Kwee Yong, Marcelo Capra, Thierry Facon, Roman Hájek, Ivan Spicka, Ross Baker, Kihyun Kim, Gracia Martinez, Chang-Ki Min, Ludek Pour, Xavier Leleu, Albert Oriol, Youngil Koh, Kenshi Suzuki, France Casca, Sandrine Mace, Marie-Laure Risse, Philippe Moreau ... other authors

Year: 2023, BLOOD CANCER JOURNAL

journal article

Isatuximab plus carfilzomib and dexamethasone in patients with relapsed multiple myeloma based on prior lines of treatment and refractory status: IKEMA subgroup analysis

Meletios A. Dimopoulos, Philippe Moreau, Bradley Augustson, Nelson Castro, Tomas Pika, Sosana Delimpasi, Javier De la Rubia, Angelo Maiolino, Tony Reiman, Joaquin Martinez-Lopez, Thomas Martin, Joseph Mikhael, Kwee Yong, Marie-Laure Risse, Gaelle Asset, Sylvia Marion, Roman Hájek ... other authors

Year: 2023, American Journal of Hematology

journal article

Length-dependent translation efficiency of ER-destined proteins

Hana Šahinbegović, Alexander Vdovin, Renáta Šnaurová, Michal Ďurech, Jakub Nezval, Jiří Sobotka, Roman Hájek, Tomáš Jelínek, Michal Šimíček ... other authors

Year: 2023, Journal of Molecular Biology

journal article

Length-Dependent Translation Efficiency of ER-Destined Proteins

Hana Šahinbegović, Alexander Vdovin, Renáta ŠNAUROVÁ, Michal Ďurech, Jakub Nezval, J. Sobotka, Roman Hájek, Tomáš Jelínek, Michal Šimíček ... other authors

Year: 2023, Current Issues in Molecular Biology

journal article

Management of patients with multiple myeloma and COVID-19 in the post pandemic era: a consensus paper from the European Myeloma Network (EMN)

Evangelos Terpos, Pellegrino Musto, Monika Engelhardt, Michel Delforge, Gordon Cook, Francesca Gay, Niels W. C. J. van de Donk, Ioannis Ntanasis-Stathopoulos, Annette Juul Vangsted, Christoph Driessen, Fredrik Schjesvold, Claudio Cerchione, Sonja Zweegman, Roman Hájek, Philippe Moreau, Hermann Einsele, Jesus San-Miguel, Mario Boccadoro, Meletios A. A. Dimopoulos, Pieter Sonneveld, Heinz Ludwig ... other authors

Year: 2023, LEUKEMIA

journal article

More Than 2% of Circulating Tumor Plasma Cells Defines Plasma Cell Leukemia-Like Multiple Myeloma

Tomáš Jelínek, Renata Bezdekova, David ŽIHALA, Tereza Ševčíková, Anjana Anilkumar Sithara, Lenka Pospisilova, Sabina Sevcikova, Petra Polackova, Martin Stork, Zdenka Knechtova, Ondřej Venglář, Veronika Kapustová, Tereza Popková, Ludmila MUROŇOVÁ, Zuzana Chyra, Matouš Hrdinka, Michal Šimíček, Juan-Jose Garces, Noemi Puig, Maria-Teresa Cedena, Artur Jurczyszyn, Jorge J. Castillo, Miroslav Penka, Jakub Radocha, Maria Victoria Mateos, Jesus F. San-Miguel, Bruno Paiva, Ludek Pour, Lucie Rihova, Roman Hájek ... other authors

Year: 2023, JOURNAL OF CLINICAL ONCOLOGY

journal article

NK92 Expressing Anti-BCMA CAR and Secreted TRAIL for the Treatment of Multiple Myeloma: Preliminary In Vitro Assessment

Benjamin Motais, Sandra Charvátová, Zuzana Walek, Roman Hájek, Julio Rodriguez Bago

Year: 2023, Cells

journal article

Novel Local "Off-the-Shelf" Immunotherapy for the Treatment of Myeloma Bone Disease

Sandra Charvátová, Benjamin Motais, Justyna Czapla, Tomasz Cichon, Ryszard Smolarczyk, Zuzana Walek, Sebastian Giebel, Roman Hájek, Julio Rodriguez Bago ... other authors

Year: 2023, CELLS

journal article

Patient Characteristics, Treatment Patterns, and Outcomes in Triple-Class Exposed Relapsed/Refractory Multiple Myeloma Patients, a Retrospective Observational Study Using Czech

Vladimir Maisnar, Ludek Pour, Ivan Spicka, Tomáš Jelínek, Jiri Minarik, Alexandra Jungova, Martin Stork, Jan Straub, Jakub Radocha, Tomas Pika, Lenka Pospisilova, Sandhya Nair, Peter Kunovszki, Roman Hájek ... other authors

Year: 2023, CLINICAL LYMPHOMA MYELOMA & LEUKEMIA

journal article

Prevention and management of adverse events during treatment with bispecific antibodies and CAR T cells in multiple myeloma: a consensus report of the European Myeloma Network

Heinz Ludwig, Evangelos Terpos, Niels van de Donk, Maria-Victoria Mateos, Philippe Moreau, Melitios-Athanasios Dimopoulos, Michel Delforge, Paula Rodriguez -Otero, Jesus San-Miguel, Kwee Yong, Francesca Gay, Hermann Einsele, Roberto Mina, Jo Caers, Christoph Driessen, Pellegrino Musto, Sonja Zweegman, Monika Engelhardt, Gordon Cook, Katja Weisel, Annemiek Broijl, Meral Beksac, Jelena Bila, Fredrik Schjesvold, Michele Cavo, Roman Hájek, Cyrille Touzeau, Mario Boccadoro, Pieter Sonneveld ... other authors

Year: 2023, LANCET ONCOLOGY

journal article

Rates of Influenza and Pneumococcal Vaccination and Correlation With Survival in Multiple Myeloma Patients

Michael A. Thompson, Mario Boccadoro, Xavier Leleu, Jorge Vela-Ojeda, Frits van Rhee, Katja C. Weisel, Robert M. Rifkin, Saad Z. Usmani, Roman Hájek, Gordon Cook, Rafat Abonour, Mira Armour, Kathryn E. Morgan, Su-Peng Yeh, Caitlin L. Costello, Jesus G. Berdeja, Faith E. Davies, Jeffrey A. Zonder, Hans C. Lee, Jim Omel, Andrew Spencer, Evangelos Terpos, Vania T. M. Hungria, Noemi Puig, Chengcheng Fu, Renda H. Ferrari, Kaili Ren, Dawn Marie Stull, Ajai Chari ... other authors

Year: 2023, CLINICAL LYMPHOMA MYELOMA & LEUKEMIA

journal article

The Benefit of Telemonitoring in the Prevention of Septic Shock in a Patient with Aggressive Non-Hodgkin’s Lymphoma

Lucie Dudová, Katarína Hradská, Tereza Popková, Michaela Skořupová, Roman Hájek

Year: 2023, Case Reports in Oncology

journal article

The management of light chain (AL) amyloidosis in Europe: clinical characteristics, treatment patterns, and efficacy outcomes between 2004 and 2018

Giovanni Palladini, Stefan Schonland, Giampaolo Merlini, Paolo Milani, Arnaud Jaccard, Frank Bridoux, Meletios A. Dimopoulos, Sriram Ravichandran, Ute Hegenbart, Wilfried Roeloffzen, M. Teresa Cibeira, Hermine Agis, Monique C. Minnema, Rui Bergantim, Roman Hájek, Cristina Joao, Alexandros Leonidakis, Giorgos Cheliotis, Pieter Sonneveld, Efstathios Kastritis, Ashutosh Wechalekar ... other authors

Year: 2023, BLOOD CANCER JOURNAL

journal article

Transcriptome Analysis of Diffuse Large B-Cell Lymphoma Cells Inducibly Expressing MyD88 L265P Mutation Identifies Upregulated CD44, LGALS3, NFKBIZ, and BATF as Downstream Targets of Oncogenic NF-κB Signaling

Marcello Turi, Anjana Anilkumar Sithara, Lucie Hofmanová, David ŽIHALA, Dhwani Radhakrishnan, Alexander Vdovin, Sofija Knápková, Tereza Ševčíková, Zuzana Chyra, Tomáš Jelínek, Michal Šimíček, Annamaria Gulla, Kenneth Carl Anderson, Roman Hájek, Matouš Hrdinka ... other authors

Year: 2023, International Journal of Molecular Sciences

journal article

Treatment of primary plasma cell leukaemia with carfilzomib and lenalidomide-based therapy (EMN12/HOVON-129): final analysis of a non-randomised, multicentre, phase 2 study

Niels W C J van de Donk, Monique C Minnema, Bronno van der Holt, Fredrik Schjesvold, Ka Lung Wu, Annemiek Broijl, Wilfried W H Roeloffzen, Alain Gadisseur, Giuseppe Pietrantuono, Ludek Pour, Vincent H J van der Velden, Thomas Lund, Massimo Offidani, Mariella Grasso, Luisa Giaccone, Wida Razawy, Paola Tacchetti, Katia Mancuso, Trine Silkjaer, Jo Caers, Sonja Zweegman, Roman Hájek, Reuben Benjamin, Annette Juul Vangsted, Mario Boccadoro, Francesca Gay, Pieter Sonneveld, Pellegrino Musto ... other authors

Year: 2023, The Lancet Oncology

journal article

Tuning CARs: recent advances in modulating chimeric antigen receptor (CAR) T cell activity for improved safety, efficacy, and flexibility

Piotr Celichowski, Marcello Turi, Sandra Charvátová, Dhwani Radhakrishnan, Neda Feizi, Zuzana Chyra, Michal Šimíček, Tomáš Jelínek, Julio Rodriguez Bago, Roman Hájek, Matouš Hrdinka ... other authors

Year: 2023, Journal of Translational Medicine

journal article

Circulating Tumor and Immune Cells for Minimally Invasive Risk Stratification of Smoldering Multiple Myeloma

Rosalinda Termini, David ŽIHALA, Evangelos Terpos, Albert Perez-Montana, Tomáš Jelínek, Marc Raab, Niels Weinhold, Elias K. Mai, Anna Luise Grab, Jill Corre, Francois Vergez, Antonio Sacco, Marco Chiarini, Viviana Giustini, Alessandra Tucci, Sara Rodriguez, Cristina Moreno, Cristina Perez, Catarina Maia, Esperanza Martin-Sanchez, Camilla Guerrero, Cirino Botta, Juan-Jose Garces, Aitziber Lopez, Luis-Esteban Tamariz-Amador, Felipe Prosper, Joan Bargay, Maria-Elena Cabezudo, Enrique M. Ocio, Roman Hájek, Joaquin Martinez-Lopez, Fernando Solano, Rebeca Iglesias, Artur Paiva, Catarina Geraldes, Helena Vitoria, Clara Gomez, Felipe De Arriba, Heinz Ludwig, Antoni Garcia-Guinon, Maria Casanova, Adrian Alegre, Valentin Cabanas, Maialen Sirvent, Albert Oriol, Javier de la Rubia, Jose-Angel Hernandez-Rivas, Luis Palomera, Maria Sarasa, Pablo Rios, Noemi Puig, Maria-Victoria Mateos, Juan Flores-Montero, Alberto Orfao, Hartmut Goldschmidt, Herve Avet-Loiseau, Aldo M. Roccaro, Jesus F. San-Miguel, Bruno Paiva ... other authors

Year: 2022, Clinical Cancer Research

journal article

Corrigendum to ‘Multiple myeloma: EHA-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up’

M. A. Dimopoulos, P. Moreau, E. Terpos, M. V. Mateos, S. Zweegman, G. Cook, M. Delforge, Roman Hájek, F. Schjesvold, M. Cavo, H. Goldschmidt, T. Facon, H. Einsele, M. Boccadoro, J. San-Miguel, P. Sonneveld, U. Mey ... other authors

Year: 2022, Annals of Oncology

journal article

Depth of response and response kinetics of isatuximab plus carfilzomib and dexamethasone in relapsed multiple myeloma

Thomas Martin, Joseph Mikhael, Roman Hájek, Kihyun Kim, Kenshi Suzuki, Cyrille Hulin, Mamta Garg, Hang Quach, Hanlon Sia, Anup George, Tatiana Konstantinova, Marie-Laure Risse, Gaelle Asset, Sandrine Mace, Helgi van de Velde, Philippe Moreau ... other authors

Year: 2022, Blood Advances

journal article

Deubiquitinase OTUD1 Resolves Stalled Translation on polyA and Rare Codon Rich mRNAs

Renáta Šnaurová, Alexander Vdovin, Michal Ďurech, Jakub Nezval, David ŽIHALA, Tomáš Jelínek, Roman Hájek, Michal Šimíček ... other authors

Year: 2022, Molecular and Cellular Biology

journal article

Efficacy and tolerability of once-weekly selinexor, bortezomib, and dexamethasone in comparison with standard twice-weekly bortezomib and dexamethasone in previously treated multiple myeloma with renal impairment: Subgroup analysis from the BOSTON study

Sosana Delimpasi, Maria Victoria Mateos, Holger W. Auner, Maria Gavriatopoulou, Meletios A. Dimopoulos, Hang Quach, Halyna Pylypenko, Roman Hájek, Xavier Leleu, Tuphan Kanti Dolai, Dinesh Kumar Sinha, Christopher P. Venner, Reuben Benjamin, Mamta Krishnan Garg, Vadim Doronin, Yair Levy, Philippe Moreau, Yi Chai, Melina Arazy, Jatin Shah, Sharon Shacham, Michael G. Kauffman, Paul G. Richardson, Sebastian Grosicki ... other authors

Year: 2022, American Journal of Hematology

journal article

Evaluation of isatuximab in patients with soft-tissue plasmacytomas: An analysis from ICARIA-MM and IKEMA

Meral Beksac, Ivan Spicka, Roman Hájek, Sara Bringhen, Tomáš Jelínek, Thomas Martin, Gabor Mikala, Philippe Moreau, Argiris Symeonidis, Andreea M. Rawlings, Helgi van de Velde, Paul G. Richardson ... other authors

Year: 2022, Leukemia Research

journal article

Genome-wide meta-analysis of monoclonal gammopathy of undetermined significance (MGUS) identifies risk loci impacting IRF-6

Alyssa Clay-Gilmour, Subhayan Chattopadhyay, Michelle A. T. Hildebrandt, Hauke Thomsen, Niels Weinhold, Pavel Vodicka, Ludmila Vodickova, Per Hoffmann, Markus M. Nothen, Karl-Heinz Jockel, Borge Schmidt, Christian Langer, Roman Hájek, Goran Hallmans, Ulrika Pettersson-Kymmer, Claes Ohlsson, Florentin Spath, Richard Houlston, Hartmut Goldschmidt, Elisabet E. Manasanch, Aaron Norman, Shaji Kumar, S. Vincent Rajkumar, Susan Slager, Asta Forsti, Celine M. Vachon, Kari Hemminki ... other authors

Year: 2022, Blood Cancer Journal

journal article

Identification of patients at high risk of secondary extramedullary multiple myeloma development

Martin Stork, Sabina Sevcikova, Jiri Minarik, Petra Krhovska, Jakub Radocha, Lenka Pospisilova, Lucie Brozova, Jiri Jarkovsky, Ivan Spicka, Jan Straub, Petr Pavlicek, Alexandra Jungova, Tomáš Jelínek, Viera Sandecka, Vladimir Maisnar, Roman Hájek, Ludek Pour ... other authors

Year: 2022, British Journal of Haematology

journal article

Involvement of Small Non-Coding RNA and Cell Antigens in Pathogenesis of Extramedullary Multiple Myeloma

Monika Vlachova, Jana Gregorova, Petra Vychytilova-Faltejskova, Natalia Anna Gablo, Lenka Radova, Lenka Pospisilova, Martina Almasi, Martin Stork, Zdenka Knechtova, Jiri Minarik, Tereza Popková, Tomáš Jelínek, Roman Hájek, Ludek Pour, Lucie Rihova, Sabina Sevcikova ... other authors

Year: 2022, International Journal of Molecular Sciences

journal article

Ixazomib, Lenalidomide and Dexamethasone in Relapsed and Refractory Multiple Myeloma in Routine Clinical Practice: Extended Follow-Up Analysis and the Results of Subsequent Therapy

Jiri Minarik, Jakub Radocha, Alexandra Jungova, Jan Straub, Tomáš Jelínek, Tomas Pika, Ludek Pour, Petr Pavlicek, Lubica Harvanova, Lenka Pospisilova, Petra Krhovska, Denisa Novakova, Pavel Jindra, Ivan Spicka, Hana Plonkova, Martin Stork, Jaroslav Bacovsky, Vladimir Maisnar, Roman Hájek ... other authors

Year: 2022, Cancers

journal article

Limited efficacy of daratumumab in multiple myeloma with extramedullary disease

Tomáš Jelínek, Tereza Ševčíková, David ŽIHALA, Tereza Popková, Veronika Kapustová, Lucie Broskevičová, Lenka Capkova, Lucie Rihova, Renata Bezdekova, Sabina Sevcikova, Vladimir Zidlik, Martin Havel, Hana Plonkova, Alexandra Jungova, Jiri Minarik, Martin Stork, Ludek Pour, Petr Pavlicek, Ivan Spicka, Vladimir Maisnar, Jakub Radocha, Michal Šimíček, Roman Hájek ... other authors

Year: 2022, Leukemia

journal article

Management of Treatment-Related Infectious Complications in High-Risk Hemato-Oncological Patients via Telemedicine

Katarína Hradská, Tereza Popková, Michaela Skořupová, Jana Mihalyova, Tomáš Jelínek, Jana Lancova, Norbert Schellong, Roman Hájek ... other authors

Year: 2022, Cancer Management and Research

journal article

Managing hematological cancer patients during the COVID-19 pandemic: an ESMO-EHA Interdisciplinary Expert Consensus

C. Buske, M. Dreyling, A. Alvarez-Larrán, J. Apperley, L. Arcaini, C. Besson, L. Bullinger, P. Corradini, M. Giovanni Della Porta, M. Dimopoulos, S. D Sa, H.T. Eich, R. Fo?, P. Ghia, M.G. da Silva, J. Gribben, Roman Hájek, C. Harrison, M. Heuser, B. Kiesewetter, J.J. Kiladjian, N. Kröger, P. Moreau, J.R. Passweg, F. Peyvandi, D. Rea, J.-M. Ribera, T. Robak, J.F. San-Miguel, V. Santini, G. Sanz, P. Sonneveld, M. von Lilienfeld-Toal, C. Wendtner, G. Pentheroudakis, F. Passamonti ... other authors

Year: 2022, ESMO Open

journal article

Melflufen or pomalidomide plus dexamethasone for patients with multiple myeloma refractory to lenalidomide (OCEAN): a randomised, head-to-head, open-label, phase 3 study

Fredrik H. Schjesvold, Meletios-Athanasios Dimopoulos, Sosana Delimpasi, Pawel Robak, Daniel Coriu, Wojciech Legiec, Ludek Pour, Ivan Spicka, Tamas Masszi, Vadim Doronin, Jiri Minarik, Galina Salogub, Yulia Alekseeva, Antonio Lazzaro, Vladimir Maisnar, Gabor Mikala, Laura Rosinol, Anna Marina Liberati, Argiris Symeonidis, Victoria Moody, Marcus Thuresson, Catriona Byrne, Johan Harmenberg, Nicolaas A. Bakker, Roman Hájek, Maria-Victoria Mateos, Paul G. Richardson, Pieter Sonneveld ... other authors

Year: 2022, Lancet Haematology

journal article

Mutation landscape of multiple myeloma measurable residual disease: identification of targets for precision medicine

Martina Zátopková, Tereza Ševčíková, Viola Fanfani, Zuzana Chyra, Lucie Rihova, Renata Bezdekova, David ŽIHALA, Kateřina Growková, Jana Filipová, Lucie Černá, Lucie Broskevicova, Fedor Kryukov, Jiri Minarik, Jana Smejkalova, Vladimir Maisnar, Lubica Harvanova, Ludek Pour, Alexandra Jungova, Tereza Popková, Julio Rodriguez Bago, Anjana Anilkumar Sithara, Matouš Hrdinka, Tomáš Jelínek, Michal Šimíček, Giovanni Stracquadanio, Roman Hájek ... other authors

Year: 2022, Blood Advances

journal article

Natural Killer Cells in the Malignant Niche of Multiple Myeloma

Ondřej Venglář, Julio Rodriguez Bago, Benjamin Motais, Roman Hájek, Tomáš Jelínek

Year: 2022, Frontiers in Immunology

journal article

Natural killer cells: Innate immune system as a part of adaptive immunotherapy in hematological malignancies

Ivo Demel, Zdeněk Kořístek, Benjamin Motais, Roman Hájek, Tomáš Jelínek

Year: 2022, American Journal of Hematology

journal article

Real-world evidence of efficacy and safety of pomalidomide and dexamethasone in relapsed/refractory multiple myeloma patients: Czech registry data

V. Sandecka, L. Pour, I. Špička, J. Minařík, J. Radocha, Tomáš Jelínek, P. Pavlíček, A. Jungová, P. Kessler, M. Wróbel, M. Štork, J. Štraub, T. Pika, L. Čápková, S. Ševčíková, V. Maisnar, Roman Hájek ... other authors

Year: 2022, Neoplasma

journal article

Subgroup analysis based on cytogenetic risk in patients with relapsed or refractory multiple myeloma in the CANDOR study

Ola Landgren, Katja Weisel, Laura Rosinol, Cyrille Touzeau, Mehmet Turgut, Roman Hájek, Peter Mollee, Jin Seok Kim, Natalie Shu, Xuguang Hu, Chuang Li, Saad Z. Usmani ... other authors

Year: 2022, British Journal of Haematology

journal article

Successful early use of anti-SARS-CoV-2 monoclonal neutralizing antibodies in SARS-CoV-2 infected hematological patients - A Czech multicenter experience

Barbora Weinbergerova, Ivo Demel, Benjamin Visek, Jan Valka, Martin Cernan, Pavel Jindra, Jan Novak, Lukas Stejskal, Flora Kovacsova, Tomas Kabut, Tomas Szotkowski, Roman Hájek, Pavel Zak, Petr Cetkovsky, Zdenek Kral, Jiri Mayer ... other authors

Year: 2022, Hematological Oncology

journal article

The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma

Alexander Vdovin, Tomáš Jelínek, David ŽIHALA, Tereza Ševčíková, Michal Ďurech, Hana Šahinbegović, Renáta Šnaurová, Dhwani Radhakrishnan, Marcello Turi, Zuzana Chyra, Tereza Popková, Ondřej Venglář, Matouš Hrdinka, Roman Hájek, Michal Šimíček ... other authors

Year: 2022, Nature Communications

journal article

Third dose of COVID-19 vaccine restores immune response in patients with haematological malignancies after loss of protective antibody titres

Ondrej Šušol, Barbora Hajkova, Hana Zelena, Roman Hájek

Year: 2022, British Journal of Haematology

journal article

Unexpected Heterogeneity of Newly Diagnosed Multiple Myeloma Patients with Plasmacytomas

Martin Stork, Sabina Sevcikova, Tomáš Jelínek, Jiri Minarik, Jakub Radocha, Tomas Pika, Lenka Pospisilova, Ivan Spicka, Jan Straub, Petr Pavlicek, Alexandra Jungova, Zdenka Knechtova, Viera Sandecka, Vladimir Maisnar, Roman Hájek, Ludek Pour ... other authors

Year: 2022, Biomedicines

journal article

ANCHOR (OP-104): Melflufen Plus Dexamethasone and Bortezomib in Relapsed/Refractory Multiple Myeloma-Optimal Dose, Updated Efficacy and Safety Results

Roman Hájek, Ludek Pour, Miquel Granell, Vladimir Maisnar, Paul Richardson, Stefan Norin, Malin Sydvander, Jakob Obermuller, Enrique Ocio ... other authors

Year: 2021, American Journal of Hematology

journal article

Bortezomib-based therapy for newly diagnosed multiple myeloma patients ineligible for autologous stem cell transplantation: Czech Registry Data

Viera Sandecka, Ludek Pour, Ivan Spicka, Jiri Minarik, Jakub Radocha, Tomáš Jelínek, Adriana Heindorfer, Petr Pavlicek, Michal Sykora, Alexandra Jungova, Petr Kessler, Marek Wrobel, David Starostka, Jana Ullrychova, Lukas Stejskal, Martin Stork, Jan Straub, Tomas Pika, Lucie Brozova, Sabina Sevcikova, Vladimir Maisnar, Roman Hájek ... other authors

Year: 2021, European Journal of Haematology

journal article

COVID-19 vaccination in patients with multiple myeloma: a consensus of the European Myeloma Network

Heinz Ludwig, Pieter Sonneveld, Thierry Facon, Jesus San-Miguel, Herve Avet-Loiseau, Mohamad Mohty, Maria-Victoria Mateos, Philippe Moreau, Michele Cavo, Charlotte Pawlyn, Sonja Zweegman, Monika Engelhardt, Christoph Driessen, Gordon Cook, Melitios A. Dimopoulos, Francesca Gay, Hermann Einsele, Michel Delforge, Jo Caers, Katja Weisel, Graham Jackson, Laurent Garderet, Niels van de Donk, Xavier Leleu, Hartmut Goldschmidt, Meral Beksac, Inger Nijhof, Martin Schreder, Niels Abildgaard, Roman Hájek, Niklas Zojer, Efstathios Kastritis, Annemiek Broijl, Fredrik Schjesvold, Mario Boccadoro, Evangelos Terpos ... other authors

Year: 2021, Lancet Haematology

journal article

Development and Validation of a Simplified Score to Predict Early Relapse in Newly Diagnosed Multiple Myeloma in a Pooled Dataset of 2,190 Patients

Gian Maria Zaccaria, Luca Bertamini, Maria Teresa Petrucci, Massimo Offidani, Paolo Corradini, Andrea Capra, Alessandra Romano, Anna Marina Liberati, Donato Mannina, Paolo de Fabritiis, Nicola Cascavilla, Marina Ruggeri, Roberto Mina, Francesca Patriarca, Giulia Benevolo, Angelo Belotti, Gianluca Gaidano, Arnon Nagler, Roman Hájek, Andrew Spencer, Pieter Sonneveld, Pellegrino Musto, Mario Boccadoro, Francesca Gay ... other authors

Year: 2021, Clinical Cancer Research

journal article

Effect of age and frailty on the efficacy and tolerability of once-weekly selinexor, bortezomib, and dexamethasone in previously treated multiple myeloma

Holger W. Auner, Maria Gavriatopoulou, Sosana Delimpasi, Maryana Simonova, Ivan Spicka, Ludek Pour, Meletios A. Dimopoulos, Iryna Kriachok, Halyna Pylypenko, Xavier Leleu, Vadim Doronin, Ganna Usenko, Roman Hájek, Reuben Benjamin, Tuphan Kanti Dolai, Dinesh Kumar Sinha, Christopher P. Venner, Mamta Garg, Don Ambrose Stevens, Hang Quach, Sundar Jagannath, Phillipe Moreau, Moshe Levy, Ashraf Badros, Larry D. Anderson Jr, Nizar J. Bahlis, Thierry Facon, Maria Victoria Mateos, Michele Cavo, Yi Chai, Melina Arazy, Jatin Shah, Sharon Shacham, Michael G. Kauffman, Paul G. Richardson, Sebastian Grosicki ... other authors

Year: 2021, American Journal of Hematology

journal article

Efficacy and safety of oral panobinostat plus subcutaneous bortezomib and oral dexamethasone in patients with relapsed or relapsed and refractory multiple myeloma (PANORAMA 3): an open-label, randomised, phase 2 study

Jacob P. Laubach, Fredrik Schjesvold, Mario Mariz, Meletios A. Dimopoulos, Ewa Lech-Maranda, Ivan Spicka, Vania T. M. Hungria, Tatiana Shelekhova, Andre Abdo, Lutz Jacobasch, Chantana Polprasert, Roman Hájek, Arpad Illes, Tomasz Wrobel, Anna Sureda, Meral Beksac, Iara Z. Goncalves, Joan Blade, S. Vincent Rajkumar, Ajai Chari, Sagar Lonial, Andrew Spencer, Pierre Maison-Blanche, Philippe Moreau, Jesus F. San-Miguel, Paul G. Richardson ... other authors

Year: 2021, Lancet Oncology

journal article

Expert review on soft-tissue plasmacytomas in multiple myeloma: definition, disease assessment and treatment considerations

Laura Rosinol, Meral Beksac, Elena Zamagni, Niels W. C. J. Van de Donk, Kenneth C. Anderson, Ashraf Badros, Jo Caers, Michele Cavo, Meletios-Athanasios Dimopoulos, Angela Dispenzieri, Hermann Einsele, Monika Engelhardt, Carlos Fernandez de Larrea, Gosta Gahrton, Francesca Gay, Roman Hájek, Vania Hungria, Artur Jurczyszyn, Nicolaus Kroeger, Robert A. Kyle, Fernando Leal da Costa, Xavier Leleu, Suzanne Lentzsch, Maria V. Mateos, Giampaolo Merlini, Mohamad Mohty, Philippe Moreau, Leo Rasche, Donna Reece, Orhan Sezer, Pieter Sonneveld, Saad Z. Usmani, Karin Vanderkerken, David H. Vesole, Anders Waage, Sonja Zweegman, Paul G. Richardson, Joan Blade ... other authors

Year: 2021, British Journal of Haematology

journal article

Focus on monoclonal antibodies targeting B-cell maturation antigen (BCMA) in multiple myeloma: update 2020

Ivo Demel, Julio Rodriguez Bago, Roman Hájek, Tomáš Jelínek

Year: 2021, BRITISH JOURNAL OF HAEMATOLOGY

journal article

Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis

Zuzana Kufová, Tereza Ševčíková, Petr Vojta, J. Puterova, L. Brozova, Kateřina Growková, Jana Filipová, Martina Zátopková, S. Grosicki, A. Barchnicka, W. Wiktor-Jedrzejczak, A. Waszczuk-Gajda, A. Jungova, A. Mikulasova, M. Hajduch, M. Mokrejs, L. Pour, M. Stork, L. Harvanova, M. Mistrik, G. Mikala, P. Robak, A. Czyz, J. Debski, L. Usnarska-Zubkiewicz, A. Jurczyszyn, L. Stejskal, G. Morgan, Fedor Kryukov, E. Budinska, Michal Šimíček, Tomáš Jelínek, Matouš Hrdinka, Roman Hájek ... other authors

Year: 2021, HAEMATOL-HEMATOL J

journal article

Isatuximab, carfilzomib, and dexamethasone in relapsed multiple myeloma (IKEMA): a multicentre, open-label, randomised phase 3 trial

Philippe Moreau, Meletios-Athanasios Dimopoulos, Joseph Mikhael, Kwee Yong, Marcelo Capra, Thierry Facon, Roman Hájek, Ivan Spicka, Ross Baker, Kihyun Kim, Gracia Martinez, Chang-Ki Min, Ludek Pour, Xavier Leleu, Albert Oriol, Youngil Koh, Kenshi Suzuki, Marie-Laure Risse, Gaelle Asset, Sandrine Mace, Thomas Martin ... other authors

Year: 2021, Lancet

journal article

Ixazomib-lenalidomide-dexamethasone in routine clinical practice: effectiveness in relapsed/refractory multiple myeloma

Roman Hájek, Jiri Minarik, Jan Straub, Ludek Pour, Alexandra Jungova, Jesus G. Berdeja, Mario Boccadoro, Lucie Brozova, Andrew Spencer, Frits van Rhee, Jorge Vela-Ojeda, Michael A. Thompson, Rafat Abonour, Ajai Chari, Gordon Cook, Caitlin L. Costello, Faith E. Davies, Vania T. M. Hungria, Hans C. Lee, Xavier Leleu, Noemi Puig, Robert M. Rifkin, Evangelos Terpos, Saad Z. Usmani, Katja C. Weisel, Jeffrey A. Zonder, Magda Barinova, Matyas Kuhn, Jiri Silar, Lenka Capkova, Kenny Galvez, Jin Lu, Jennifer Elliott, Dawn Marie Stull, Kaili Ren, Vladimir Maisnar ... other authors

Year: 2021, Future Oncology

journal article

Management of patients with multiple myeloma beyond the clinical-trial setting: understanding the balance between efficacy, safety and tolerability, and quality of life

Evangelos Terpos, Joseph Mikhael, Roman Hájek, Ajai Chari, Sonja Zweegman, Hans C. Lee, Maria-Victoria Mateos, Alessandra Larocca, Karthik Ramasamy, Martin Kaiser, Gordon Cook, Katja C. Weisel, Caitlin L. Costello, Jennifer Elliott, Antonio Palumbo, Saad Z. Usmani ... other authors

Year: 2021, Blood Cancer Journal

journal article

Mass spectrometry for the evaluation of monoclonal proteins in multiple myeloma and related disorders: an International Myeloma Working Group Mass Spectrometry Committee Report

David L. Murray, Noemi Puig, Sigurdur Kristinsson, Saad Z. Usmani, Angela Dispenzieri, Giada Bianchi, Shaji Kumar, Wee Joo Chng, Roman Hájek, Bruno Paiva, Anders Waage, S. Vincent Rajkumar, Brian Durie ... other authors

Year: 2021, Blood Cancer Journal

journal article

Minimal residual disease assessment by multiparameter flow cytometry in transplant-eligible myeloma in the EMN02/HOVON 95 MM trial

Stefania Oliva, Davine Hofste op Bruinink, Lucie Rihova, Mattia D Agostino, Lucia Pantani, Andrea Capra, Bronno van der Holt, Rossella Troia, Maria Teresa Petrucci, Tania Villanova, Pavla Vsianska, Romana Jugooa, Claudia Brandt-Hagens, Milena Gilestro, Massimo Offidani, Rossella Ribolla, Monica Galli, Roman Hájek, Francesca Gay, Michele Cavo, Paola Omede, Vincent H. J. van der Velden, Mario Boccadoro, Pieter Sonneveld ... other authors

Year: 2021, Blood Cancer Journal

journal article

Multiple myeloma: EHA-ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

M. A. Dimopoulos, P. Moreau, E. Terpos, M. Mateos, S. Zweegman, G. Cook, M. Delforge, Roman Hájek, F. Schjesvold, M. Cavo, H. Goldschmidt, T. Facon, H. Einsele, M. Boccadoro, J. San-Miguel, P. Sonneveld, U. Mey ... other authors

Year: 2021, Annals of Oncology

journal article

Octogenarian newly diagnosed multiple myeloma patients without geriatric impairments: the role of age > 80 in the IMWG frailty score

Mattia D Agostino, Alessandra Larocca, Massimo Offidani, Anna Marina Liberati, Gianluca Gaidano, Maria Teresa Petrucci, Daniele Derudas, Andrea Capra, Renato Zambello, Nicola Cascavilla, Paolo de Fabritiis, Vanessa Innao, Francesca Bonello, Francesca Patriarca, Giulia Benevolo, Nicola Giuliani, Gabriele Aitoro, Tommasina Guglielmelli, Francesco Di Raimondo, Paolo Corradini, Roman Hájek, Pieter Sonneveld, Mario Boccadoro, Sara Bringhen ... other authors

Year: 2021, Blood Cancer Journal

journal article

Plasmacytoid Dendritic Cells in Patients with MGUS and Multiple Myeloma

Andrea Knight, Lucie Rihova, Romana Kralova, Miroslav Penka, Zdenek Adam, Ludek Pour, Martin Piskacek, Roman Hájek ... other authors

Year: 2021, Journal of Clinical Medicine

journal article

Promising Immunotherapeutic Modalities for B-Cell Lymphoproliferative Disorders

Jana Fečková Mihályová, Katarína Hradská, Tomáš Jelínek, Benjamin Motais, Piotr Celichowski, Roman Hájek ... other authors

Year: 2021, International Journal of Molecular Sciences

journal article

Prvních 50 COVID-19 pozitivních pacientů na Klinice hematoonkologie Fakultní nemocnice Ostrava v roce 2020

O. Šušol, B. Hájková, Jana Fečková Mihályová, M. Kaščák, Juraj Ďuraš, J. Zuchnická, H. Plonková, K. Hradská, Tomáš Jelínek, Milan Navrátil, K. Benková, Lukáš Stejskal, Zdeněk Kořístek, T. Popková, D. Buffa, I. Demel, L. Muroňová, B. Dluhošová, L. Szeligová, L. Dudová, Hana Zelená, Jaromír Gumulec, Roman Hájek ... other authors

Year: 2021, Transfuze a Hematologie Dnes

journal article

Real-world comparative effectiveness of triplets containing bortezomib (B), carfilzomib (C), daratumumab (D), or ixazomib (I) in relapsed/refractory multiple myeloma (RRMM) in the US

Faith Davies, Robert Rifkin, Caitlin Costello, Gareth Morgan, Saad Usmani, Rafat Abonour, Antonio Palumbo, Dorothy Romanus, Roman Hájek, Evangelos Terpos, Dasha Cherepanov, Dawn Marie Stull, Hui Huang, Xavier Leleu, Jesus Berdeja, Hans C. Lee, Katja Weisel, Michael Thompson, Mario Boccadoro, Jeffrey Zonder, Gordon Cook, Noemi Puig, Jorge Vela-Ojeda, Eileen Farrelly, Aditya Raju, Marlo Blazer, Ajai Chari ... other authors

Year: 2021, Annals of Hematology

journal article

Recommendations for vaccination in multiple myeloma: a consensus of the European Myeloma Network

Heinz Ludwig, Mario Boccadoro, Philippe Moreau, Jesus San-Miguel, Michele Cavo, Charlotte Pawlyn, Sonja Zweegman, Thierry Facon, Christoph Driessen, Roman Hájek, Melitios A. Dimopoulos, Francesca Gay, Herve Avet-Loiseau, Evangelos Terpos, Niklas Zojer, Mohamad Mohty, Maria-Victoria Mateos, Hermann Einsele, Michel Delforge, Jo Caers, Katja Weisel, Graham Jackson, Laurent Garderet, Monika Engelhardt, Niels van de Donk, Xavier Leleu, Hartmut Goldschmidt, Meral Beksac, Inger Nijhof, Niels Abildgaard, Sara Bringhen, Pieter Sonneveld ... other authors

Year: 2021, Leukemia

journal article

Selection, Expansion, and Unique Pretreatment of Allogeneic Human Natural Killer Cells with Anti-CD38 Monoclonal Antibody for Efficient Multiple Myeloma Treatment

Benjamin Motais, Sandra Charvátová, Zuzana Walek, Matouš Hrdinka, Ryszard Smolarczyk, Tomasz Cichoń, Justyna Czapla, Sebastian Giabel, Michal Šimíček, Tereza Ševčíková, Jiří Sobotka, Zdeněk Kořístek, Roman Hájek, Julio Rodriguez Bago ... other authors

Year: 2021, Cells

journal article

Selinexor, bortezomib, and dexamethasone versus bortezomib and dexamethasone in previously treated multiple myeloma: Outcomes by cytogenetic risk

Shambavi Richard, Ajai Chari, Sosana Delimpasi, Maryana Simonova, Ivan Spicka, Ludek Pour, Iryna Kriachok, Meletios A. Dimopoulos, Halyna Pylypenko, Holger W. Auner, Xavier Leleu, Ganna Usenko, Roman Hájek, Reuben Benjamin, Tuphan Kanti Dolai, Dinesh Kumar Sinha, Christopher P. Venner, Mamta Garg, Don Ambrose Stevens, Hang Quach, Sundar Jagannath, Phillipe Moreau, Moshe Levy, Ashraf Badros, Larry D. Anderson, Nizar J. Bahlis, Thierry Facon, Maria Victoria Mateos, Michele Cavo, Hua Chang, Yosef Landesman, Yi Chai, Melina Arazy, Jatin Shah, Sharon Shacham, Michael G. Kauffman, Sebastian Grosicki, Paul G. Richardson ... other authors

Year: 2021, AMERICAN JOURNAL OF HEMATOLOGY

journal article

Selinexor, selective inhibitor of nuclear export: Unselective bullet for blood cancers

Kateřina Benková, Jana Fečková Mihályová, Roman Hájek, Tomáš Jelínek

Year: 2021, Blood Reviews

journal article

Standardization of flow cytometric minimal residual disease assessment in international clinical trials. A feasibility study from the European Myeloma Network

Davine Hofste op Bruinink, Stefania Oliva, Lucie Rihova, Alexander Schmitz, Milena Gilestro, Jeroen te Marvelde, Romana Kralova, Helle Hoholt, Annemiek Broijl, Hans Erik Johnsen, Roman Hájek, Mario Boccadoro, Pieter Sonneveld, Paola Omede, Vincent H. J. van der Velden ... other authors

Year: 2021, Haematologica

journal article

Standardization of flow cytometric minimal residual disease assessment in international clinical trials. A feasibility study from the European Myeloma Network

Davine Hofste Op Bruinink, Stefania Oliva, Lucie Rihova, Alexander Schmitz, Milena Gilestro, Jeroen te Marvelde, Romana Kralova, Helle Hoholt, Annemiek Broijl, Hans Erik Johnsen, Roman Hájek, Mario Boccadoro, Pieter Sonneveld, Paola Omede, Vincent H. J. van der Velden ... other authors

Year: 2021, Haematologica

journal article

Survival benefit of ixazomib, lenalidomide and dexamethasone (IRD) over lenalidomide and dexamethasone (Rd) in relapsed and refractory multiple myeloma patients in routine clinical practice

Jiri Minarik, Tomas Pika, Jakub Radocha, Alexandra Jungova, Jan Straub, Tomáš Jelínek, Ludek Pour, Petr Pavlicek, Martin Mistrik, Lucie Brozova, Petra Krhovska, Katerina Machalkova, Pavel Jindra, Ivan Spicka, Hana Plonkova, Martin Stork, Jaroslav Bacovsky, Lenka Capkova, Michal Sykora, Petr Kessler, Lukas Stejskal, Adriana Heindorfer, Jana Ullrychova, Tomas Skacel, Vladimir Maisnar, Roman Hájek ... other authors

Year: 2021, BMC CANCER

journal article

Toxicity of Immune-Checkpoint Inhibitors in Hematological Malignancies

Katarina Hradska, Roman Hájek, Tomáš Jelínek

Year: 2021, Frontiers in Pharmacology

journal article

Treatment of relapsed and refractory multiple myeloma: recommendations from the International Myeloma Working Group

Philippe Moreau, Shaji K. Kumar, Jesus San Miguel, Faith Davies, Elena Zamagni, Nizar Bahlis, Heinz Ludwig, Joseph Mikhael, Evangelos Terpos, Fredrik Schjesvold, Thomas Martin, Kwee Yong, Brian G. M. Durie, Thierry Facon, Artur Jurczyszyn, Surbhi Sidana, Noopur Raje, Niels van de Donk, Sagar Lonial, Michele Cavo, Sigurdur Y. Kristinsson, Suzanne Lentzsch, Roman Hájek, Kenneth C. Anderson, Cristina Joao, Hermann Einsele, Pieter Sonneveld, Monika Engelhardt, Rafael Fonseca, Annette Vangsted, Katja Weisel, Rachid Baz, Vania Hungria, Jesus G. Berdeja, Fernando Leal da Costa, Angelo Maiolino, Anders Waage, David H. Vesole, Enrique M. Ocio, Hang Quach, Christoph Driessen, Joan Blade, Xavier Leleu, Eloisa Riva, Peter Leif Bergsagel, Jian Hou, Wee Joo Chng, Ulf-Henrik Mellqvist, Dominik Dytfeld, Jean-Luc Harousseau, Hartmut Goldschmidt, Jacob Laubach, Nikhil C. Munshi, Francesca Gay, Meral Beksac, Luciano J. Costa, Martin Kaiser, Parameswaran Hari, Mario Boccadoro, Saad Z. Usmani, Sonja Zweegman, Sarah Holstein, Orhan Sezer, Simon Harrison, Hareth Nahi, Gordon Cook, Maria-Victoria Mateos, S. Vincent Rajkumar, Meletios A. Dimopoulos, Paul G. Richardson ... other authors

Year: 2021, Lancet Oncology

journal article

Urine immunofixation negativity is not necessary for complete response in intact immunoglobulin multiple myeloma: Retrospective real-world confirmation

Jakub Radocha, Tomáš Jelínek, Ludek Pour, Ivan Spicka, Jiri Minarik, Tereza Popkova, Alexandra Jungova, Petr Pavlicek, Lucie Brozova, Martin Stork, Frantisek Sedlak, Petra Krhovska, Vladimir Maisnar, Adriana Heindorfer, Michal Sykora, Marek Wrobel, Peter Mikula, Petr Kessler, Jana Ullrychova, Roman Hájek ... other authors

Year: 2021, International Journal of Laboratory Hematology

journal article

Washing transplants with Sepax 2 reduces the incidence of side effects associated with autologous transplantation and increases patients' comfort

Lucie Huvarova, Zdeněk Kořístek, Tomáš Jelínek, Lucie Cerna, Jana Smejkalova, Milan Navrátil, Lukas Grebenicek, Ivana Tvrda, Magda Michalikova, Roman Hájek ... other authors

Year: 2021, Transfusion

journal article

2021 European Myeloma Network review and consensus statement on smoldering multiple myeloma: how to distinguish (and manage) Dr. Jekyll and Mr. Hyde

Pellegrino Musto, Monika Engelhardt, Jo Caers, Niccolo Bolli, Martin Kaiser, Niels van de Donk, Evangelos Terpos, Annemiek Broijl, Carlos Fernandez de Larrea, Francesca Gay, Hartmut Goldschmidt, Roman Hájek, Annette Juul Vangsted, Elena Zamagni, Sonja Zweegman, Michele Cavo, Meletios Dimopoulos, Hermann Einsele, Heinz Ludwig, Giovanni Barosi, Mario Boccadoro, Maria-Victoria Mateos, Pieter Sonneveld, Jesus San Miguel ... other authors

Year: 2021, Haematologica

journal article

A Bird's-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers

Benjamin Motais, Sandra Charvátová, Matouš Hrdinka, Michal Šimíček, Tomáš Jelínek, Tereza Ševčíková, Zdeněk Kořístek, Roman Hájek, Julio Rodriguez Bago ... other authors

Year: 2020, CANCERS

journal article

A Noninterventional, Observational, European Post-Authorization Safety Study of Patients With Relapsed/Refractory Multiple Myeloma Treated With Lenalidomide

Gamberi Barbara, Berthou Christian, Hernandez Miguel, Semenzato Gianpietro, Tholouli Eleni, Roman Hájek, Caers Jo, Dimopoulos Meletios, Minnema Monique C., Andreasson Bjorn, Parreira Joana, Crotty Gerard, Remes Kari, Kueenburg Elisabeth, Rosettani Barbara, Di Micco Antonia, Peters Sarah, Bacon Pamela, Blau Igor Wolfgang ... other authors

Year: 2020, Clinical Lymphoma Myeloma & Leukemia

journal article

A phase 2 study of ibrutinib in combination with bortezomib and dexamethasone in patients with relapsed/refractory multiple myeloma

Roman Hájek, Luděk Pour, Edyta Dawbovská, Muhit Ozcan, Jesus Martin Sanchez, Ivan Špička ... other authors

Year: 2020, EUROPEAN JOURNAL OF HAEMATOLOGY

journal article

Autologous haematopoietic stem-cell transplantation versus bortezomib-melphalan-prednisone, with or without bortezomib-lenalidomide-dexamethasone consolidation therapy, and lenalidomide maintenance for newly diagnosed multiple myeloma (EMN02/HO95): a multicentre, randomised, open-label, phase 3 study

Cavo Michele, Gay Francesca, Beksac Meral, Pantani Lucia, Petrucci Maria Teresa, Dimopoulos Meletios A., Dozza Luca, van der Holt Bronno, Zweegman Sonja, Oliva Stefania, van der Velden Vincent H. J., Zamagni Elena, Palumbo Giuseppe A., Patriarca Francesca, Montefusco Vittorio, Galli Monica, Maisnar Vladimir, Gamberi Barbara, Hansson Markus, Belotti Angelo, Pour Ludek, Ypma Paula, Grasso Mariella, Croockewit Alexsandra, Ballanti Stelvio, Offidani Massimo, Vincelli Iolanda D., Zambello Renato, Liberati Anna Marina, Andersen Niels Frost, Broijl Annemiek, Troia Rossella, Pascarella Anna, Benevolo Giulia, Levin Mark-David, Bos Gerard, Ludwig Heinz, Aquino Sara, Morelli Anna Maria, Wu Ka Lung, Boersma Rinske, Roman Hájek, Durian Marc, di Toritto Tommaso Caravita, Zander Thilo, Specchia Giorgina, Waage Anders, Gimsing Peter, Mellqvist Ulf-Henrik, Kooy Marinus van Marwijk, Minnema Monique, Mandigers Caroline, Cafro Anna Maria, Palmas Angelo, Carvalho Susanna, Spencer Andrew, Boccadoro Mario, Sonneveld Pieter ... other authors

Year: 2020, LANCET HAEMATOLOGY

journal article

Bispecifické protilátky v léčbě non-hodgkinských lymfomů

Jana Fečková Mihályová, Katarína Hradská, Tomáš Jelínek, Roman Hájek

Year: 2020, Farmakoterapie

journal article

Bortezomib, Melphalan, and Dexamethasone for Light-Chain Amyloidosis

Kastritis Efstathios, Leleu Xavier, Arnulf Bertrand, Zamagni Elena, Cibeira Maria Teresa, Kwok Fiona, Roman Hájek, Moreau Philippe, Jaccard Arnaud, Schoenland Stefan O., Filshie Robin, Nicolas-Virelizier Emmanuelle, Mateos Maria-Victoria, Wechalekar Ashutosh, Hachulla Eric, Milani Paolo, Dimopoulos Meletios A., Fermand Jean-Paul, Foli Andrea, Gavriatopoulou Maria, Klersy Catherine, Palumbo Antonio, Sonneveld Pieter, Johnsen Hans Erik, Merlini Giampaolo, Palladini Giovanni ... other authors

Year: 2020, Journal of Clinical Oncology

journal article

Bortezomib Retreatment Is Effective in Relapsed Multiple Myeloma Patients - Real-Life Clinical Practice Data

M. Stork, S. Ševčíková, L. Brožová, I. Špička, V. Maisnar, J. Minařík, A. Jungová, E. Gregora, R. Velichová, Roman Hájek, Tomáš Jelínek, L. Pour ... other authors

Year: 2020, Neoplasma

journal article

Dynamics of tumor-specific cfDNA in response to therapy in multiple myeloma patients

David Vrabel, Lenka Sedlaříková, Lenka Besse, Lucie Říhová, Renata Bezděková, Martina Almasi, Veronika Kubaczková, Lucie Brožová, Jiří Jarkovský, Hana Plonková, Tomáš Jelínek, Viera Sandecká, Martin Stork, Luděk Pour, Sabina Ševčíková, Roman Hájek ... other authors

Year: 2020, European Journal of Haematology

journal article

Efficacy and Safety of ABP 798: Results from the JASMINE Trial in Patients with Follicular Lymphoma in Comparison with Rituximab Reference Product

Niederwieser Dietger, Hamm Caroline, Cobb Patrick, Mo Mindy, Forsyth Cecily, Tucci Alessandra, Hanes Vladimir, Delwail Vincent, Roman Hájek, Chien David ... other authors

Year: 2020, Targeted Oncology

journal article

First-line therapy with either bortezomibmelphalan- prednisone or lenalidomidedexamethasone followed by lenalidomide for transplant-ineligible multiple myeloma patients: a pooled analysis of two randomized trials

A. Larocca, R. Mina, M. Offidani, Roman Hájek

Year: 2020, Haematologica

journal article

Focus on monoclonal antibodies targeting B-cell maturation antigen (BCMA) in multiple myeloma: update 2020

Demel Ivo, Julio Rodriguez Bago, Roman Hájek, Tomáš Jelínek

Year: 2020, British Journal of Haematology

journal article

Identification of patients with smouldering multiple myeloma at ultra-high risk of progression using serum parameters: the Czech Myeloma Group model

Roman Hájek, Sandecka Viera, Spicka Ivan, Raab Marc, Goldschmidt Hartmut, Beck Susanne, Minarik Jiri, Pavlicek Petr, Radocha Jakub, Heindorfer Adriana, Tomáš Jelínek, Stejskal Lukas, Brozova Lucie, Sevcikova Sabina, Straub Jan, Pika Tomas, Pour Ludek, Maisnar Vladimir, Seckinger Anja, Hose Dirk ... other authors

Year: 2020, British Journal of Haematology

journal article

Identifying and treating candidates for checkpoint inhibitor therapies in multiple myeloma and lymphoma

Katarina Hradská, Michal Kaščák, Roman Hájek, Tomáš Jelínek

Year: 2020, Expert Review of Hematology

journal article

Intercellular Mitochondrial Transfer in the Tumor Microenvironment

Hana Šahinbegović, Tomáš Jelínek, Matouš Hrdinka, Julio Rodriguez Bago, Marcello Turi, Tereza Ševčíková, Amina Kurtovic-Kotaric, Roman Hájek, Michal Šimíček ... other authors

Year: 2020, Cancers

journal article

International Myeloma Working Group risk stratification model for smoldering multiple myeloma (SMM)

Mateos Maria-Victoria, Kumar Shaji, Dimopoulos Meletios A., Gonzalez-Calle Veronica, Kastritis Efstathios, Roman Hájek, Fernandez De Larrea Carlos, Morgan Gareth J., Merlini Giampaolo, Goldschmidt Hartmut, Geraldes Catarina, Gozzetti Alessandro, Kyriakou Charalampia, Garderet Laurent, Hansson Markus, Zamagni Elena, Fantl Dorotea, Leleu Xavier, Kim Byung-Su, Esteves Graca, Weiss Brendan M., Rajkumar S. Vincent, Durie Brian G. M., San-Miguel Jesus ... other authors

Year: 2020, Blood Cancer Journal

journal article

Ixazomib as Postinduction Maintenance for Patients With Newly Diagnosed Multiple Myeloma Not Undergoing Autologous Stem Cell Transplantation: The Phase III TOURMALINE-MM4 Trial

Dimopoulos Meletios A., Špička Ivan, Quach Hang, Oriol Albert, Roman Hájek, Garg Mamta, Beksac Meral, Bringhen Sara, Katodritou Eirini, Chng Wee-Joo, Leleu Xavier, Iida Shinsuke, Mateos María-Victoria, Morgan Gareth, Vorog Alexander, Labotka Richard, Wang Bingxia, Palumbo Antonio, Lonial Sagar, TOURMALINE-MM4 study group undefined ... other authors

Year: 2020, Journal of Clinical Oncology

journal article

Léčba nemocné s nízce rizikovou primární myelofibrózou ruxolitinibem

Jana Zuchnická, Lukáš Stejskal, Roman Hájek

Year: 2020, We Make Media, s.r.o.

specialist book chapter

Léčba relapsu akutní promyelocytární leukemie oxidem arsenitým u chronicky dialyzované pacientky

Kateřina Benková, Zdeněk Kořístek, Petra Richterová, Jana Fečková Mihályová, Dagmar Zámoravcová, Karel Lach, Roman Hájek ... other authors

Year: 2020, Onkologická revue

journal article

Lenalidomide-based induction and maintenance in elderly newly diagnosed multiple myeloma patients: updated results of the EMN01 randomized trial

Bringhen Sara, D Agostino Mattia, Paris Laura, Ballanti Stelvio, Pescosta Norbert, Spada Stefano, Pezzatti Sara, Grasso Mariella, Rota-Scalabrini Delia, De Rosa Luca, Pavone Vincenzo, Gazzera Giulia, Aquino Sara, Poggiu Marco, Santoro Armando, Gentile Massimo, Baldini Luca, Petrucci Maria Teresa, Tosi Patrizia, Marasca Roberto, Cellini Claudia, Palumbo Antonio, Falco Patrizia, Roman Hájek, Boccadoro Mario, Larocca Alessandra ... other authors

Year: 2020, Haematologica

journal article

Management of patients with multiple myeloma in the era of COVID-19 pandemic: a consensus paper from the European Myeloma Network (EMN)

Terpos Evangelos, Engelhardt Monika, Cook Gordon, Gay Francesca, Mateos Maria-Victoria, Ntanasis-Stathopoulos Ioannis, van de Donk Niels W. C. J., Avet-Loiseau Herve, Roman Hájek, Vangsted Annette Juul, Ludwig Heinz, Zweegman Sonja, Moreau Philippe, Einsele Hermann, Boccadoro Mario, San Miguel Jesus, Dimopoulos Meletios A., Sonneveld Pieter ... other authors

Year: 2020, LEUKEMIA

journal article

Melflufen for relapsed and refractory multiple myeloma

Oriol Albert, Larocca Alessandra, Leleu Xavier, Roman Hájek, Hassoun Hani, Rodriguez-Otero Paula, Paner Agne, Schjesvold Fredrik H., Gullbo Joachim, Richardson Paul G. ... other authors

Year: 2020, Expert Opinion on Investigational Drugs

journal article

Methodology and results of real-world cost-effectiveness of carfilzomib in combination with lenalidomide and dexamethasone in relapsed multiple myeloma using registry data

M. Campioni, I. Agirrezabel, Roman Hájek, J. Minařík, L. Pour, I. Špička, S. Gonzalez-McQuire, P. Jandová, V. Maisnar ... other authors

Year: 2020, European Journal of Health Economics

journal article

Mnohočetný myelom

Tomáš Jelínek, Roman Hájek

Year: 2020, Maxdorf, s.r.o.

specialist book chapter

Monoclonal antibodies in the treatment of AL amyloidosis: co-targetting the plasma cell clone and amyloid deposits

Tereza Popková, Roman Hájek, Tomáš Jelínek

Year: 2020, BRITISH JOURNAL OF HAEMATOLOGY

journal article

Monočetný myelom

Roman Hájek, Vladimír Maisnar, Jiří Minařík, Lukáš Stejskal, Petr Pavlíček, Tomáš Jelínek, Alexandra Jungová, Petr Kesseler, Luděk Pour, Michal Sýkora, Ivan Špička, Jana Ullrychová, Adriana Heindorfer, Marek Wróbel ... other authors

Year: 2020, Česká hematologická společnost ČLS JEP

specialist book chapter

Once- versus twice-weekly carfilzomib in relapsed and refractory multiple myeloma by select patient characteristics: phase 3 ARROW study subgroup analysis

Dimopoulos Meletios A., Niesvizky Ruben, Weisel Katja, Siegel David S., Roman Hájek, Mateos Maria-Victoria, Huang Mei, Zahlten-Kumeli Anita, Moreau Philippe ... other authors

Year: 2020, Blood Cancer Journal

journal article

Once-per-week selinexor, bortezomib, and dexamethasone versus twice-per-week bortezomib and dexamethasone in patients with multiple myeloma (BOSTON): a randomised, open-label, phase 3 trial

Grosicki Sebastian, Simonova Maryana, Spicka Ivan, Pour Ludek, Kriachok Iryrna, Gavriatopoulou Maria, Pylypenko Halyna, Auner Holger W., Leleu Xavier, Doronin Vadim, Usenko Ganna, Bahlis Nizar J., Roman Hájek, Benjamin Reuben, Dolai Tuphan K., Sinha Dinesh K., Venner Christopher P., Garg Mamta, Gironella Mercedes, Jurczyszyn Artur, Robak Pawel, Galli Monica, Wallington-Beddoe Craig, Radinoff Atanas, Salogub Galina, Stevens Don A., Basu Supratik, Liberati Anna M., Quach Hang, Goranova-Marinova Vesselina S., Bila Jelena, Katodritou Eirini, Oliynyk Hanna, Korenkova Sybiryna, Kumar Jeevan, Jagannath Sundar, Moreau Phillipe, Levy Moshe, White Darrell, Gatt Moshe E., Facon Thierry, Cavo Michele, Reece Donna, Anderson Larry D., Saint-Martin Jean-Richard, Jeha Jacqueline, Joshi Anita A., Chai Yi, Li Lingling, Peddagali Vishnuvardhan, Arazy Melina, Shah Jatin, Shacham Sharon, Kauffman Michael G., Dimopoulos Meletios A., Richardson Paul G., Delimpasi Sosana ... other authors

Year: 2020, Lancet

journal article

Osteolytická ložiska, hyperkalcemie a paraprotein, ale myelom to není

Katarína Hradská, Tomáš Jelínek, Juraj Ďuraš, Jana Fečková Mihályová, Tereza Popková, Jakub Cvek, Bukovanský K., Martin Havel, Veronika Spáčilová, Roman Hájek ... other authors

Year: 2020, Vnitrni Lekarstvi

journal article

Outcome of paraosseous extra-medullary disease in newly diagnosed multiple myeloma patients treated with new drugs

M. Vittorio, G. Francesca, S. Spada, Roman Hájek

Year: 2020, HAEMATOLOGICA

journal article

Real-world effectiveness and safety of ixazomib-lenalidomide-dexamethasone in relapsed/refractory multiple myeloma

E. Terpos, K. Ramasamy, N. Maouche, J. Minařík, I. Ntanasis-Stathopoulos, E. Katodritou, W. M. Jenner, H. Plonková, M. Kotsoupolou, J. Kothari, Tomáš Jelínek, A. M. Dimopoulos, A. Zomas, Roman Hájek ... other authors

Year: 2020, ANNALS OF HEMATOLOGY

journal article

Real-world outcomes and factors impacting treatment choice in relapsed and/or refractory multiple myeloma (RRMM): a comparison of VRd, KRd, and IRd

A. Chari, P.G. Richardson, D. Romanus, Roman Hájek

Year: 2020, Expert Review of Hematology

journal article

Současná doporučení pro léčbu mnohočetného myelomu

Hana Plonková, Tomáš Jelínek, Tereza Popková, Roman Hájek

Year: 2020, Acta medicinae

journal article

Transcriptional profiling of circulating tumor cells in multiple myeloma: a new model to understand disease dissemination

Garces Juan-Jose, Michal Šimíček, Vicari Marco, Brozova Lucie, Burgos Leire, Bezdekova Renata, Alignani Diego, Calasanz Maria-Jose, Kateřina Growková, Goicoechea Ibai, Agirre Xabier, Pour Ludek, Prosper Felipe, Rios Rafael, Martinez-Lopez Joaquin, Millacoy Pamela, Palomera Luis, Del Orbe Rafael, Perez-Montana Albert, Garate Sonia, Blanco Laura, Lasa Marta, Maiso Patricia, Flores-Montero Juan, Sanoja-Flores Luzalba, Chyra Zuzana, Alexander Vdovin, Sevcikova Tereza, Tomáš Jelínek, Botta Cirino, El Omri Halima, Keats Jonathan, Orfao Alberto, Roman Hájek, San-Miguel Jesus F., Paiva Bruno ... other authors

Year: 2020, LEUKEMIA

journal article

Venetoclax plus bortezomib and dexamethasone in heavily pretreated end-stage myeloma patients without t(11;14): A real-world cohort

Tomáš Jelínek, Popkova Tereza, Juraj Ďuraš, Jana Fečková Mihályová, Michal Kaščák, Kateřina Benková, Plonkova Hana, Lucie Černá, Zdeněk Kořístek, Michal Šimíček, Roman Hájek ... other authors

Year: 2020, HEMATOLOGICAL ONCOLOGY

journal article

Získaná hemofilie A: možnosti diagnostiky a léčby

Jaromír Gumulec, Zdeněk Kořístek, Milan Navrátil, David Buffa, Katarína Hradská, Lucie Recová, Radomíra Hrdličková, Martin Pulcer, Zuzana Čermáková, Roman Hájek ... other authors

Year: 2020, Acta Medicinae

journal article

Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial

Roman Hájek

Year: 2019, LANCET

journal article

Carfilzomib or bortezomib with melphalan-prednisone for transplant-ineligible patients with newly diagnosed multiple myeloma

T. Tacon, JH Lee, P. Morau, R. Niesvizky, M. Dimopoulos, Roman Hájek, L. Pour, A. Jurczyszyn, L. Qiu, Z. Klippel, A. Zahlten-Kumeli, M. Osman, B. Paiva, J. San-Miguel ... other authors

Year: 2019, BLOOD

journal article

Comprehensive care improves the prognosis of women with severe HELLP syndrome and postpartal thrombotic microangiopathic syndrome

Jaromír Gumulec, Ondřej Šimetka, Erika Doležálková, Zdeněk Kořístek, Milan Navrátil, Lucie Broskevičová, Lucie Recová, Kateřina Andelová, I. Lochman, J. Martínek, Roman Hájek, David Kaspřák, M. Tvrdá, Kateřina Notari, Lucie Gregorová, Petra Kovářová ... other authors

Year: 2019

abstract in proceedings

Cytarabine plus G-CSF is more effective than cyclophosphamide plus G-CSF as a stem cell mobilization regimen in multiple myeloma

Roman Hájek, Tomáš Jelínek, Lucie Adamusová, Tereza Popková, Jana Smejkalová, Michal Šimíček, Dana Salounová, Michal Kaščák, Jana Mihalyová, Hana Plonková, Juraj Ďuraš, Milan Navrátil, Zdeněk Kořístek ... other authors

Year: 2019, BONE MARROW TRANSPL

journal article

Development of an Initial Conceptual Model of Multiple Myeloma to Support Clinical and Health Economics Decision Making

Sebastian Gonzalez-McQuire, MA. Dimopoulos, Katja Weisel, Roman Hájek, M. Campioni, C. Bennison, W. Xu, K. Pantiri, M. Hensen, E. Terpoz, S. Knop ... other authors

Year: 2019, MDM Policy & Practice

journal article

Extramedullary disease in multiple myeloma - controversies and future directions

Roman Hájek, Sabina Ševčíková, Jiří Minařík, Martin Stork, Tomáš Jelínek, Luděk Pour ... other authors

Year: 2019, BLOOD REV

journal article

Roman Hájek, Kim Cocks, Jaqueline Buchanan, Katja Weisel, Shibao Feng, Martin Keiser, Maria-Victoria Mateos, Meletios A. Dimopoulos, Philippe Morea, Heinz Ludwig ... other authors

Year: 2019, BLOOD CANCER JOURNAL

journal article

Chimeric antigen receptor T-cell therapy for multiple myeloma: a consensus statement from The European Myeloma Network

Philippe Moreau, Pieter Sonneveld, Mario Boccadoro, Gordon Cook, Ma Victoria Mateos, Hareth Nahi, Hartmut Goldschmidt, Meletios A. Dimopoulos, Paulo Lucio, Joan Blade, Michel Delforge, Roman Hájek, Heinz Ludwig, Thierry Facon, Jesus F. San Miguel, Hermann Einsele ... other authors

Year: 2019, HAEMATOLOGICA

journal article

Lenalidomide and dexamethasone in treatment of patients with relapsed and refractory multiple myeloma - analysis of data from the Czech Myeloma Group Registry of Monoclonal Gammopathies

Roman Hájek, V. Maisnar, Z. Stefanikova, I. Spicka, L. Pour, J. Minařík, M. Flochová, J. Radocha, E. Gregora, N. Stecová, Tomáš Jelínek, A. Jungová, E. Kralíková, L. Brožová ... other authors

Year: 2019, NEOPLASMA

journal article

Lenalidomide Maintenance with or without Prednisone in Newly Diagnosed Myeloma Patients: A Pooled Analysis

F. Bonello, S. Pulini, S. Ballanti, M. Gentile, S. Spada, O. Annibali, P. Omede, S. Ronconi, C. Cangialosi, L. Podda, Roman Hájek ... other authors

Year: 2019, CANCERS

journal article

Levels of CEACAM6 in Peripheral Blood Are Elevated in Patients with Plasma Cell Disorders: A Potential New Diagnostic Marker and a New Therapeutic Target?

N. Steiner, D. Nachbaur, B. Borjan, S. Ševčíková, G. Goebel, E. Gunsilius, Roman Hájek ... other authors

Year: 2019, DISEASE MARKERS

journal article

Multiple myeloma in patients up to 30 years of age: a multicenter retrospective study of 52 cases

Roman Hájek, A. Jurczyszyn, J. Davila, K.M. Kortüm, D.S. Jayabalan, R. Vij, M. Fiala, V. Milunovic, C.S. Chim, K. Wiśniewska-Piaty, A. Waszczuk-Gajda, E. Crusoe, P. Robak, M. Raźny, D. Zawirska, M. Bittrich, H. Nahi, H. Liu, J.J. Castillo, D.H. Vesole ... other authors

Year: 2019, Leukemia and Lymphoma

journal article

PREDICTIVE VALUE OF PRIMA‐PROGNOSTIC INDEX (PRIMA‐PI) IN FIRST RELAPSE OF FOLLICULAR LYMPHOMA

Juraj Ďuraš, V. Procházka, D. Belada, A. Janíková, H. Móciková, Roman Hájek, M. Trněný ... other authors

Year: 2019

abstract in proceedings

Secondary plasma cell leukemia: a multicenter retrospective study of 101 patients

Roman Hájek, A. Jurczyszyn, J.J. Castillo, I. Avivi, J. Czepiel, J. Davila, R. Vij, M.A. Fiala, A. Gozzetti, N. Grzaśko, V. Milunovic, I. Hus, K. Madry, A. Waszcuk-Gajda, L. Usnarska-Zubkiewicz, J. Debski, E. Atilla, M. Beksac, G. Mele, W. Sawicki, D. Jaybalan, G. Charliński, A.G. Szabo, M. Delforge, A. Kopacz, D. Fantl, A. Waage, E. Crusoe, V. Hungria, P. Richardson, J. Laubach, T. Guerrero-Garcia, J. Liu, D.H. Vesole ... other authors

Year: 2019, Leukemia & Lymphoma

journal article

Simplified novel prognostic score for real-life older adults with multiple myelomaregistry-based analysis

Roman Hájek, J. Radocha, L. Brožová, L. Pour, I. Spicka, J. Minařík, E. Gregorová, A. Jungová, Tomáš Jelínek, A. Heindorfer, M. Sykora, V. Maisnar ... other authors

Year: 2019, ANN HEMATOL

journal article

Single agent daratumumab in advanced multiple myeloma possesses significant efficacy even in an unselected 'real-world' population

Roman Hájek, Jiří Minařík, Luděk Pour, Vladimír Maisnar, Ivan Špička, Alexandra Jungová, Tomáš Jelínek, Lucie Brožová, Petra Krhovská, Vlastimil Scudla ... other authors

Year: 2019, BIOMEDICAL PAPERS-OLOMOUC

journal article

Single-agent venetoclax induces MRD-negative response in relapsed primary plasma cell leukemia with t(11;14)

Roman Hájek, Tomáš Jelínek, Jana Fečková Mihályová, Juraj Ďuraš, Tereza Popková, Kateřina Benková, Hana Plonková, Jana Zuchnická, Lucie Broskevičová, Lucie Huvarová, Lucie Černá, Kateřina Growková, Michal Šimíček, Martin Havel, Jaromír Gumulec, Zdeněk Kořístek, Bruno Paiva, Petra Richterová, Milan Navrátil, Michal Kascák ... other authors

Year: 2019, AMERICAN JOURNAL OF HEMATOLOGY

journal article

Treatment of Relapsed/Refractory Hodgkin Lymphoma: Real-World Data from the Czech Republic and Slovakia

Zdeněk Král, Jozef Michalka, Heidi Mociková, Jana Marková, Alice Sýkorová, David Belada, Alexandra Jungová, Samuel Vokurka, Marie Lukášová, Vít Procházka, Juraj Ďuraš, Roman Hájek, Ladislav Dušek, Luhos Drgona, Miriam Ladická, Veronika Ballová, Andrei Vranovský ... other authors

Year: 2019, JOURNAL OF CANCER

journal article

A phase I/II dose-escalation study investigating all-oral ixazomib-melphalanprednisone induction followed by single-agent ixazomib maintenance in transplant-ineligible newly diagnosed multiple myeloma

Jesús F. San-Miguel, Maria-Asunción Echeveste Gutierrez, Ivan Špicka, María-Victoria Mateos, Kevin Song, Michael D. Craig, Joan Bladé, Roman Hájek, Christine Chen, Alessandra Di Bacco, Jose Estevam, Neeraj Gupta, Catriona Byrne, Vickie Lu, Helgi van de Velde, Sagar Lonial ... other authors

Year: 2018, HAEMATOL-HEMATOL J

journal article

Adjusted comparison of daratumumab monotherapy versus real-world historical control data from the Czech Republic in heavily pretreated and highly refractory multiple myeloma patients

Tomáš Jelínek, Roman Hájek, V. Maisnar, L. Pour, I. Špička, J. Minařík, E. Gregora, P. Kessler, M. Sýkora, H. Fraňková, D. Adamová, M. Wróbel, P. Mikula, J. Jarkovský, J. Diels, X. Gatopoulou, H Besson, L. Brožová, T. lto, Š. Veselá ... other authors

Year: 2018, Current Medical Research and Opinion

journal article

Analysis of carfilzomib cardiovascular safety profile across relapsed and/or refractory multiple myeloma clinical trials

Roman Hájek, AK Stewart, SD Russell, P. Moreau, J. Herrmann, J. Banchs, J. Groarke, AR Lyon, GN Batty, S. Ro, M. Huang, KS Iskander, D. Lenihan, A. Chari ... other authors

Year: 2018, Blood Advances

journal article

Automatizované promývání transplantátů krvetvorných buněk pro autologní použití

Lucie Adamusová, Zdeněk Kořístek, Jana Smejkalová, Milan Navrátil, Lukáš Grebeníček, Ivana Tvrdá, Magda Michalíková, Roman Hájek ... other authors

Year: 2018, Transfuze a hematologie dnes

journal article

CD38 cílená léčba u mnohočetného myelomu

Tomáš Jelínek, Jana Fečková Mihályová, Roman Hájek

Year: 2018, Vnitřní lékařství

journal article

Clinical predictors of long-term survival in newly diagnosed transplant eligible multiple myeloma - an IMWG Research Project

A. Hoering, M. Cavo, SZ Usmani, J. San Miguel, H. Goldschimdt, I. Turesson, JJ Lahuerta, M. Attal, B. Barlogie, JH Lee, S. Kumar, S. Lenhoff, G. Morgan, SV Rajkumar, BGM Durie, P. Moreau, Roman Hájek ... other authors

Year: 2018, Blood Cancer Journal

journal article

European myeloma network recommendations on diagnosis and management of patients with rare plasma cell dyscrasias

Roman Hájek, M. Gavriatopoulou, P. Musto, J. Caers, G. Merlini, E. Kastritis, N. van de Donk, F. Gay, U. Hegenbart, S. Zweegman, B. Bruno, C. Straka, MA. Dimopoulos, H. Einsele, M. Boccadoro, P. Sonneveld, M. Engelhardt, E. Terpos ... other authors

Year: 2018, Leukemia

journal article

From transplant to novel cellular therapies in multiple myeloma: European Myeloma Network guidelines and future perspectives

F. Gay, M. Engelhardt, E. Terpos, R. Wasch, L. Giaccone, H.W. Auner, J. Caers, M. Gramatzki, N. van de Donk, S. Oliva, E. Zamagni, L. Garderet, Ch. Straka, Roman Hájek, H. Ludwig, H. Einsele, M. Dimopoulos, M. Boccadoro, N. Kroger, M. Cavo, H. Goldschmidt, B. Bruno, P. Sonneveld ... other authors

Year: 2018, HAEMATOLOGICA

journal article

Maintenance Treatment and Survival in Patients With Myeloma A Systematic Review and Network Meta-analysis

F. Gay, G. Jackson, L. Rosinol, S.A. Holstein, P. Moreau, S. Spada, F. Davies, J.J. Lahuerta, X. Leleu, S. Bringhen, A. Evangelista, C. Hulin, U. Panzani, D.A. Cairns, F. Di Raimondo, M. Macro, A.M. Liberati, C. Pawlyn, M. Offidani, A. Spencer, Roman Hájek, E. Terpos, G.J. Morgan, J. Blade, P. Sonneveld, J. San-Miguel, P.L. McCarthy, H. Ludwig, M. Boccadoro, MV Mateos, M. Attal ... other authors

Year: 2018, Jama Oncology

journal article

Newly designed 11-gene panel reveals first case of hereditary amyloidosis captured by massive parallel sequencing

Zuzana Kufová, Tereza Ševčíková, J. Januska, P. Vojta, A. Boday, P. Vanickova, Jana Filipová, Kateřina Growková, Tomáš Jelínek, M. Hajduch, Roman Hájek ... other authors

Year: 2018, JOURNAL OF CLINICAL PATHOLOGY

journal article

Obinutuzumab v první linii léčby chronické lymfocytární leukemie - zkušenosti z klinické praxe

J. Zuchnicka, J. Feckova Mihalyova, L. Istvanikova, Roman Hájek

Year: 2018, Remedia, Od teorie k praxi

journal article

Plasma levels of the angiogenic cytokine Endocan are elevated in patients with multiple myeloma

Roman Hájek

Year: 2018

abstract in proceedings

Prevention and management of adverse events of novel agents in multiple myeloma: a consensus of the European Myeloma Network

Roman Hájek, H. Ludwig, M. Delforge, T. Facon, H. Einsele, F. Gay, P. Moreau, H. Avet-Loiseau, M. Boccadoro, M. Mohty, M. Cavo, MA Dimopoulos, JF San-Miguel, E. Terpos, S. Zweegman, L. Garderet, MV Mateos, G. Cook, X. Leleu, H. Goldschmidt, G. Jackson, M. Kaiser, K. Weisel, NWCJ van de Donk, A. Waage, M. Beksac, UH Mellqvist, M. Engelhardt, J. Caers, C. Driessen, J. Blade, P. Sonneveld ... other authors

Year: 2018, LEUKEMIA

journal article

Prognostic indicators in primary plasma cell leukaemia: a multicentre retrospective study of 117 patients

A. Jurczyszyn, J. Radocha, J. Davila, M.A. Fiala, A. Gozzetti, N. Grzasko, P. Robak, I. Hus, A. Waszczuk-Gajda, R. Guzicka-Kazimierczak, E. Atilla, G. Mele, W. Sawicki, D.S. Jayabalan, G. Charlinski, A.G. Szabo, Roman Hájek ... other authors

Year: 2018, BRITISH JOURNAL OF HAEMATOLOGY

journal article

Real-world Outcomes of Multiple Myeloma: Retrospective Analysis of the Czech Registry of Monoclonal Gammopathies

Roman Hájek, J. Jarkovsky, V. Maisnar, L. Pour, I. Spicka, J. Minarik, E. Gregora, P. Kessler, M. Sykora, H. Frankova, M. Campion, L. DeCosta, M. Treur, S. Gonzales-McQuire, W. Bouwmeester ... other authors

Year: 2018, Clinical Lymphoma Myeloma & Leukemia

journal article

The metabolomic plasma profile of myeloma patients is considerably different from healthy subjects and reveals potential new therapeutic targets

Roman Hájek, Normann Steiner, Udo Müller, Sabina Sevcikova, Bojana Borjan, Karin Jöhrer, Georg Göbel, Andreas Pircher, Eberhard Gunsilius ... other authors

Year: 2018, PUBLIC LIBRARY SCIENCE

journal article

The Plasma Levels of the Angiogenic Cytokine Endocan Are Elevated in Patients with Multiple Myeloma

Roman Hájek, N. Steiner, S. Sevcikova, B. Borjan, G. Untergasser, G. Göbel, E. Gunsilius ... other authors

Year: 2018, Anticancer Research

journal article

The start of a new wave: Developments in proteasome inhibition in multiple myeloma

Roman Hájek, K. Yong, S. Gonzalez-McQuire, Z. Szabo, P. Schoen

Year: 2018, EUROPEAN JOURNAL OF HAEMATOLOGY

journal article

Treatment and outcome patterns in European patients with Waldenstrom's macroglobulinaemia: a large, observational, retrospective chart review

Roman Hájek, C. Buske, S. Sadullah, E. Kastritis, A. Tedeschi, R. García-Sanz, L. Bolkun, X. Leleu, W. Willenbacher, MC. Minnema, M. Cheng, E. Bilotti, T. Graef, MA. Dimopoulos ... other authors

Year: 2018, The Lancet Haematology

journal article

Treatment Intensification With Autologous Stem Cell Transplantation and Lenalidomide Maintenance Improves Survival Outcomes of Patients With Newly Diagnosed Multiple Myeloma in Complete Response

Roman Hájek, R. Mina, MT Petrucci, S. Spada, F. Patriarca, C. Cerrato, L. De Paoli, N. Pescosta, R. Ria, A. Malfitano, P. Musto, L. Baldini, T. Guglielmelli, B. Gamberi, D. Mannina, G. Benevolo, R. Zambello, AP Falcone, A. Palumbo, A. Nagler, V. Calafiore, A. Spencer, M. Boccadoro, P. Corradini, S. Bringhen ... other authors

Year: 2018, CLINICAL LYMPHOMA MYELOMA & LEUKEMIA

journal article

Treatment Outcomes of Real Life Elderly Multiple Myeloma Patients: A Analysis from Registry of Monoclonal Gammopathies (RMG)

Roman Hájek

Year: 2018

abstract in proceedings

Update on PD-1/PD-L1 Inhibitors in Multiple Myeloma

Tomáš Jelínek, Roman Hájek, B. Paiva

Year: 2018, Frontiers in Immunology

journal article

Validation of multiple myeloma risk stratification indices in routine clinical practice: Analysis of data from the Czech Myeloma Group Registry of Monoclonal Gammopathies

Jakub Radocha, Vladimír Maisnar, Luděk Pour, Ivan Špička, Jiři Minařík, Petr Pavlíček, Alexandra Jungová, Marta Krejčí, Tomáš Pika, Jan Straub, Lucie Brožová, Lukáš Stejskal, Adriana Heindorfer, Pavel Jindra, Petr Kessler, Peter Mikula, Michal Sýkora, Marek Wróbel, Jiří Jarkovský, Roman Hájek, Lenka Szeligová ... other authors

Year: 2018, Cancer Medicine

journal article

Venetoclax: A new wave in hematooncology

Jana Fečková Mihályová, Tomáš Jelínek, K. Growková, Matouš Hrdinka, Michal Šimíček, Roman Hájek ... other authors

Year: 2018, EXPERIMENTAL HEMATOLOGY

journal article

A randomized phase III study of carfilzomib vs low-dose corticosteroids with optional cyclophosphamide in relapsed and refractory multiple myeloma (FOCUS)

Roman Hájek, T. Masszi, M. T. Petrucci, A. Palumbo, L. Rosinol, A. Nagler, K. L. Yong, A. Oriol, J. Minarik, M.A. Dimopoulos, V. Maisnar, D. Rossi, H. Kasparu, J. Van Droogenbroeck, D. B. Yehuda, I. Hardan, M. Jenner, M. Calbecka, M. Dávid, J. de la Rubia, J. Drach, Z. Gasztonyi, S. Górnik, X. Leleu, M. Munder, M. Offidani, N. Zojer, K. Rajangam, Y-L Chang, J. F. San-Miguel, H. Ludwig, L. Pour ... other authors

Year: 2017, LEUKEMIA

journal article

Activity of aldehyde dehydrogenase in B-cell and plasma cell subsets of monoclonal gammopathy patients and healthy donors

P. Všianská, R. Bezděková, Fedor Kryukov, M. Almáši, L. Pour, M. Penka, Roman Hájek, L. Říhová ... other authors

Year: 2017, EUROPEAN JOURNAL OF HAEMATOLOGY

journal article

Asymptomatic and treatment-requiring multiple myeloma - Data from the czech registry of monoclonal gammopathies

L. Brozova, J. Jarkovsky, L. Pour, J. Minarik, A. Jungova, E. Gregora, I. Spicka, V. Maisnar, Roman Hájek ... other authors

Year: 2017, Klinicka Onkologie

journal article

Autologous transplant vs oral chemotherapy and lenalidomide in newly diagnosed young myeloma patients: a pooled analysis

F. Gay, S. Oliva, M.T. Petrucci, V. Montefusco, C. Conticello, P. Musto, L. Catalano, A. Evangelista, S. Spada, P. Campbell, R. Ria, M. Salvini, M. Offidani, A.M. Carella, P. Omede, A.M. Liberati, R. Troia, A.M. Cafro, A. Malfitano, A.P. Falcone, T. Caravita, F. Patriarca, A. Nagler, A. Spencer, Roman Hájek, A. Palumbo, M. Boccadoro ... other authors

Year: 2017, LEUKEMIA

journal article

Bezdůvodný rozruch, nebo neuvěřitelný progres?

Roman Hájek

Year: 2017, Remedia

journal article

Biobanking strategy and sample preprocessing for integrative research in monoclonal gammopathies

Tereza Ševčíková, Kateřina Growková, Zuzana Kufová, Jana Filipová, P. Vrublová, Tomáš Jelínek, Zdeněk Kořístek, Fedor Kryukov, Elena Kryukova, Roman Hájek ... other authors

Year: 2017, JOURNAL OF CLINICAL PATHOLOGY

journal article

Biomarkers in immunoglobulin light chain amyloidosis

Zuzana Kufová, Tereza Ševčíková, Kateřina Growková, P. Vojta, Jana Filipová, Z. Adam, L. Pour, M. Penka, R. Rysava, P. Nemec, L. Brozova, P. Vychytilova, A. Jurczyszyn, S. Grosicki, A. Barchnicka, M. Hajduch, Roman Hájek, Michal Šimíček ... other authors

Year: 2017, Klinicka Onkologie

journal article

Carfilzomib and dexamethasone vs bortezomib and dexamethasone in patients with relapsed multiple myeloma: results of the phase 3 study ENDEAVOR (NCT01568866) according to age subgroup

H. Ludwig, M. A. Dimopoulos, P. Moreau, W-J Chng, H. Goldschmidt, Roman Hájek, T. Facon, L. Pour, R. Niesvizky, A. Oriol, L. Rosinol, A. Suvorov, G. Gaidano, T. Pika, K. Weisel, V. Goranova-Marinova, A. Palumbo, H. H. Gillenwater, N. Mohamed, S. Aggarwal, S. Feng, D. Joshua ... other authors

Year: 2017, LEUKEMIA & LYMPHOMA

journal article

Carfilzomib, lenalidomide, and dexamethasone in patients with relapsed multiple myeloma categorised by age: secondary analysis from the phase 3 ASPIRE study

A. Meletios, A. K. Stewart, T. Masszi, I. Špička, A. Oriol, Roman Hájek, L. Rosinol, D. Siegel, G. G. Mihaylov, V. Goranova-Marinova, P. Rajnics, A. Suvorov, R. Niesvizky, A. Jakubowiak, J. San-Miguel, H. Ludwig, A. Palumbo, M. Obreja, S. Aggarwal, P. Moreau ... other authors

Year: 2017, BRITISH JOURNAL OF HAEMATOLOGY

journal article

Carfilzomib or bortezomib in relapsed or refractory multiple myeloma (ENDEAVOR): an interim overall survival analysis of an open-label, randomised, phase 3 trial

M. A. Dimopoulos, H. Goldschmidt, R. Niesvizky, D. Joshua, W-J Chng, A. Oriol, R. Z. Orlowski, H. Ludwig, T. Facon, Roman Hájek, K. Weisel, V. Hungria, L. Minuk, S. Feng, A. Zahlten-Kumeli, A. S. Kimball, P. Moreau ... other authors

Year: 2017, LANCET ONCOLOGY

journal article

Carfilzomib-dexamethasone vs bortezomib-dexamethasone in relapsed or refractory multiple myeloma by cytogenetic risk in the phase 3 study ENDEAVOR

W-J Chng, H. Goldschmidt, M. A. Dimopoulos, P. Moreau, D. Joshua, A. Palumbo, T. Facon, H. Ludwig, L. Pour, R. Niesvizky, A. Oriol, L. Rosinol, A. Suvorov, G. Gaidano, T. Pika, K. Weisel, V. Goranova-Marinova, H. H. Gillenwater, N. Mohamed, S. Feng, S. Aggarwal, Roman Hájek ... other authors

Year: 2017, LEUKEMIA

journal article

Carfilzomib-lenalidomide-dexamethasone vs lenalidomide-dexamethasone in relapsed multiple myeloma by previous treatment

M. A. Dimopoulos , A. K. Stewart, T. Masszi, I. Špička, A. Oriol, Roman Hájek, L. Rosinol, D. Siegel, G. G. Mihaylov, V. Goranova-Marinova, P. Rajnics, A. Suvorov, R. Niesvizky, A. Jakubowiak, J. San-Miguel, H. Ludwig, S. Ro, S. Aggarwal, P. Moreau, A. Palumbo ... other authors

Year: 2017, BLOOD CANCER JOURNAL

journal article

CRISPR in research and treatment of multiple myeloma

Michal Šimíček, Kateřina Growková, Roman Hájek

Year: 2017, Klinicka Onkologie

journal article

Current applications of multiparameter flow cytometry in plasma cell disorders

Tomáš Jelínek, R. Bezdekova, R. Zatopkova, L. Burgos, Michal Šimíček, Tereza Ševčíková, B. Paiva, Roman Hájek ... other authors

Year: 2017, BLOOD CANCER JOURNAL

journal article

Czech registry of monoclonal gammopathies - Technical solution, data collection and visualisation

L. Brozova, D. Schwarz, I. Snabl, J. Kalina, B. Pavlickova, M. Komenda, J. Jarkovsky, P. Nemec, D. Horinek, Z. Stefanikova, L. Pour, Roman Hájek, V. Maisnar ... other authors

Year: 2017, Klinicka Onkologie

journal article

Daratumumab - Naděje pro myelomové pacienty, výzva pro klinické laboratoře

Tomáš Jelínek, Martin Kořístka, Zuzana Čermáková, Roman Hájek

Year: 2017, Klinicka Onkologie

journal article

Diagnostic Tools of Waldenström's Macroglobulinemia - Best Possibilities for Non-invasive and Long-term Disease Monitoring

Kateřina Growková, Zuzana Kufová, Tereza Ševčíková, Jana Filipová, M. Kascak, Tomáš Jelínek, S. Grosicki, A. Barchnicka, L. Roziakova, M. Mistrik, M. Simicek, Roman Hájek ... other authors

Year: 2017, Klinická onkologie

journal article

DIFFERENCES IN PATIENT AND DISEASE CHARACTERISTICS OBSERVED AT INITIATION OF FIRST-LINE AND INITIATION OF SECOND-LINE TREATMENT IN PATIENTS WITH RELAPSED MULTIPLE MYELOMA IN THE CZECH REPUBLIC

Roman Hájek

Year: 2017

abstract in proceedings

Effects of single-agent bortezomib as post-transplant consolidation therapy on multiple myeloma-related bone disease: a randomized phase II study

O. Sezer, M. Beksac, Roman Hájek, G. Sucak, S. Cagirgan, W. Linkesch, O. M. Akay, Z. Gülbas, H. Nahi, T. Plesner, J. A. Snowden, A. Timuragaoglu, T. Dechow, A. Lang, T. Tuglular, J. Drach, G. Armbrecht, A. Potamianou, C. Couturier, R. A. Olie, C. Feys, N. Allietta, E. Terpos ... other authors

Year: 2017, BRITISH JOURNAL OF HAEMATOLOGY

journal article

Efficacy and safety of carfilzomib regimens in multiple myeloma patients relapsing after autologous stem cell transplant: ASPIRE and ENDEAVOR outcomes

P. Hari, M.-V. Mateos, R. Abonour, S. Knop, W. Bensinger, H. Ludwig, K. Song, Roman Hájek, P. Moreau, D.S. Siegel, S. Feng, M. Obreja, S.K. Aggarwal, K. Iskander, H. Goldschmidt ... other authors

Year: 2017, LEUKEMIA

journal article

Epidemiology of multiple myeloma in the Czech Republic

D. Maluskova, I. Svobodova, M. Kucerova, L. Brozova, J. Muzik, J. Jarkovsky, Roman Hájek, V. Maisnar, L. Dusek ... other authors

Year: 2017, Klinicka Onkologie

journal article

Expression and release of glucose-regulated protein-78 (GRP78) in multiple myeloma

N. Steiner, B. Borjan, Roman Hájek, K. Jöhrer, G. Göbel, W. Willenbacher, J. Kern, E. Gunsilius, G. Untergasser ... other authors

Year: 2017, Oncotarget

journal article

High levels of FLT3-ligand in bone marrow and peripheral blood of patients with advanced multiple myeloma

N. Steiner, Roman Hájek, S. Sevcikova, B. Borjan, K. Jöhrer, G. Göbel, G. Untergasser, E. Gunsilius ... other authors

Year: 2017, PLOS ONE

journal article

Chromosome 1 amplification has similar prognostic value to del(17p13) and t(4;14)(p16;q32) in multiple myeloma patients: analysis of real-life data from the Polish Myeloma Study Group

N. Grzasko, Roman Hájek, M. Hus, S. Chocholska, M. Morawska, K. Giannopoulos, K. Czarnocki, A. Druzd-Sitek, B. Pienkowska-Grela, J. Rygier, L. Usnarska-Zubkiewicz, D. Dytfeld, T. Kubicki, A. Jurczyszyn, M. Korpysz, A. Dmoszynska ... other authors

Year: 2017, Leukemia and Lymphoma

journal article

IgM myeloma: A multicenter retrospective study of 134 patients

J. J. Castillo, A. Jurczyszyn, L. Brozova, E. Crusoe, J. Czepiel, J. Davila, A. Dispenzieri, M. Eveillard, M. A. Fiala, I. M. Ghobrial, A. Gozzetti, J. N. Gustine, Roman Hájek, V. Hungria, J. Jarkovsky, D. Jayabalan, J. P. Laubach, B. Lewicka, V. Maisnar, E. E. Manasanch, P. Moreau, E. A. Morgan, H. Nahi, R. Niesvizky, C. Paba-Prada, T. Pika, L. Pour, J. L. Reagan, P. G. Richardson, J. Shah, I. Spicka, R. Vij, A. Waszczuk-Gajda, M. A. Gertz ... other authors

Year: 2017, AMERICAN JOURNAL OF HEMATOLOGY

journal article

Impact of prior treatment on patients with relapsed multiple myeloma treated with carfilzomib and dexamethasone vs bortezomib and dexamethasone in the phase 3 ENDEAVOR study

P. Moreau, D. Joshua, W-J Chng, A. Palumbo, H. Goldschmidt, Roman Hájek, T. Facon, H. Ludwig, L. Pour, R. Niesvizky, A. Oriol, L. Rosinol, A. Suvorov, G. Gaidano, T. Pika, K. Weisel, V. Goranova-Marinova, H. H. Gillenwater, N. Mohamed, S. Aggarwal , S. Feng, M. A. Dimopoulos ... other authors

Year: 2017, LEUKEMIA

journal article

INITIAL PHASE 2 RESULTS OF IBRUTINIB COMBINED WITH BORTEZOMIB/DEXAMETHASONE IN PREVIOUSLY TREATED PATIENTS WITH MULTIPLE MYELOMA

Roman Hájek

Year: 2017

abstract in proceedings

Lymfomy z B-buněk marginální zóny

Juraj Ďuraš, Michal Kaščák, Roman Hájek

Year: 2017, Onkológia

journal article

MINIMAL RESIDUAL DISEASE BY MULTIPARAMETER FLOW CYTOMETRY IN TRANSPLANT ELIGIBLE PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA ENROLLED IN THE EMN02/HO95 PHASE 3 TRIAL

Roman Hájek

Year: 2017

abstract in proceedings

MINIMAL RESIDUAL DISEASE BY MULTIPARAMETER FLOW CYTOMETRY IN TRANSPLANT ELIGIBLE PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA: RESULTS FROM THE EMN02/HO95 PHASE 3 TRIAL

Roman Hájek

Year: 2017

abstract in proceedings

Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up

P. Moreau, J. San Miguel, P. Sonneveld, M. V. Mateos, E. Zamagni, H. Avet-Loiseau, Roman Hájek, M. A. Dimopoulos, H. Ludwig, H. Einsele, S. Zweegman, T. Facon, M. Cavo, E. Terpos, H. Goldschmidt, M. Attal, C. Buske ... other authors

Year: 2017, ANNALS OF ONCOLOGY

journal article

Obinutuzumab v léčbě nemocných s chronickou lymfocytární leukémií a s folikulárním lymfomem

J. Zuchnická, J. F. Mihályová, Juraj Ďuraš, Roman Hájek

Year: 2017, Onkologická revue

journal article

Obtižne interpretovatelné nálezy elektroforéz a imunofixací u pacientu s mnohočetným myelomem po autologní transplantaci

Pavlína Kušnierová, David Zeman, Radka Šigutová, Zdeněk Švagera, Lenka Zahradová, Roman Hájek ... other authors

Year: 2017, Klinicka Biochemie a Metabolismus

journal article

PD-1/PD-L1 inhibitors in haematological malignancies

Tomáš Jelínek, J. Mihalyova, M. Kascak, J. Duras, Roman Hájek

Year: 2017, IMMUNOLOGY

journal article

PD-1/PD-L1 inhibitors in haematological malignancies: update 2017

Tomáš Jelínek, Roman Hájek, J. Mihalyova, M. Kascak, J. Duras

Year: 2017, Immunology

journal article

PD-1/PD-L1 inhibitors in multiple myeloma: The present and the future

Tomáš Jelínek, Roman Hájek

Year: 2017, ONCOIMMUNOLOGY

journal article

Pixantron v léčbě non-hodgkinských lymfomů

Juraj Ďuraš, Michal Kaščák, Milan Navrátil, Roman Hájek

Year: 2017, Onkologická revue

journal article

Proteasome inhibitors in AL amyloidosis: focus on mechanismof action and clinical activity

Tomáš Jelínek, Elena Kryukova, Zuzana Kufová, Fedor Kryukov, Roman Hájek

Year: 2017, Hematological Oncology

journal article

RISK STRATIFICATION ALGORITHM USING REAL-WORLD DATA FROM PATIENTS WITH RELAPSED AND/ OR REFRACTORY MULTIPLE MYELOMA: DESCRIPTION OF CLINICAL OUTCOME BY TREATMENT REGIMEN

Roman Hájek

Year: 2017

abstract in proceedings

Současný algoritmus léčby nemocných s mnohočetným myelomem - kam kráčí?

Roman Hájek, Tomáš Jelínek

Year: 2017, Acta medicinae

journal article

THE ORAL PROTEASOME INHIBITOR IXAZOMIB IN COMBINATION WITH MELPHALAN-PREDNISONE FOR PATIENTS WITH NEWLY DIAGNOSED MULTIPLE MYELOMA: PHASE 1/2 DOSE-ESCALATION STUDY (NCT01335685)

Roman Hájek

Year: 2017

abstract in proceedings

The spectrum of somatic mutations in monoclonal gammopathy of undetermined significance indicates a less complex genomic landscape than that in multiple myeloma

A. Mikulasova, Ch. P. Wardell, A. Murison, E. M. Boyle, G. H. Jackson, J. Smetana, Zuzana Kufová, L. Pour, V. Sandecka, M. Almasi, P. Vsianska, E. Gregora, P. Kuglik, Roman Hájek, F. E. Davies, G. J. Morgan, B. A. Walker ... other authors

Year: 2017, HAEMATOLOGICA

journal article

Waldenström's macroglobulinemia: Two malignant clones in a monoclonal disease? Molecular background and clinical reflection

Kateřina Growková, Elena Kryukova, Zuzana Kufová, Jana Filipová, Tereza Ševčíková, L. Rihova, M. Kascak, Fedor Kryukov, Roman Hájek ... other authors

Year: 2017, EUROPEAN JOURNAL OF HAEMATOLOGY

journal article

Whole exome sequencing of aberrant plasma cells in a patient with multiple myeloma minimal residual disease

M. Zatopkova, Jana Filipová, Tomáš Jelínek, Tereza Ševčíková, Michal Šimíček, L. Rihova, R. Bezdekova, Kateřina Growková, Zuzana Kufová, J. Smejkalova, M. Hajduch, L. Pour, J. Minarik, A. Jungova, V. Maisnar, Fedor Kryukov, Roman Hájek ... other authors

Year: 2017, Klinicka Onkologie

journal article

A Randomized Phase III Trial of Melphalan and Dexamethasone (MDex) Versus Bortezomib, Melphalan and Dexamethasone (BMDex) for Untreated Patients with AL Amyloidosis

Roman Hájek

Year: 2016

abstract in proceedings

A SUBSTUDY OF THE PHASE 3 ENDEAVOR STUDY: SERIAL ECHOCARDIOGRAPHIC ASSESSMENT OF PATIENTS WITH RELAPSED MULTIPLE MYELOMA (RMM) RECEIVING CARFILZOMIB PLUS DEXAMETHASONE OR BORTEZOMIB PLUS DEXAMETHASONE

Roman Hájek

Year: 2016

abstract in proceedings

AUTOLOGNÍ TRANSPLANTACE KMENOVÝCH BUNĚK U WALDENSTRÖMOVY MAKROGLOBULINEMIE

M. Kasčák, J. Duraš, M. Navrátil, Roman Hájek

Year: 2016, Transfuze a hematologie dnes

journal article

Carfilzomib and dexamethasone versus bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma (ENDEAVOR): a randomised, phase 3, open-label, multicentre study

M.A. Dimopoulos, P. Moreau, A. Palumbo, D. Joshua, L. Pour, Roman Hájek, T. Facon, H. Ludwig, A. Oriol, H. Goldschmidt, L. Rosiňol, J. Straub, A. Suvorov, C. Araujo, E. Rimashevskaya, T. Pika, G. Gaidano, K. Weisel, V. Goranova-Marinova, A. Schwarer, L. Minuk, T. Masszi, I. Karamanesht, M. Offidani, V. Hungria, A. Spencer, R. Z Orlowski, H. H Gillenwater, N. Mohamed, S. Feng, W.J. CHng ... other authors

Year: 2016, LANCET ONCOLOGY

journal article

CARFILZOMIB AND DEXAMETHASONE VERSUS BORTEZOMIB AND DEXAMETHASONE: SUBGROUP ANALYSIS OF THE PHASE 3 ENDEAVOR STUDY TO EVALUATE THE IMPACT OF PRIOR TREATMENT ON PATIENTS WITH RELAPSED MULTIPLE MYELOMA

Roman Hájek

Year: 2016

abstract in proceedings

CARFILZOMIB AND DEXAMETHASONE VS BORTEZOMIB AND DEXAMETHASONE IN PATIENTS WITH RELAPSED MULTIPLE MYELOMA: ANALYSIS OF THE PHASE 3 ENDEAVOR STUDY BY AGE SUBGROUP

Roman Hájek

Year: 2016

abstract in proceedings

CARFILZOMIB AND DEXAMETHASONE VS BORTEZOMIB AND DEXAMETHASONE IN PATIENTS WITH RELAPSED MULTIPLE MYELOMA: RESULTS OF THE PHASE 3 STUDY ENDEAVOR (NCT01568866)

Roman Hájek

Year: 2016

abstract in proceedings

CARFILZOMIB AND DEXAMETHASONE VS BORTEZOMIB AND DEXAMETHASONE: SUBGROUP ANALYSIS OF PATIENTS WITH RELAPSED MULTIPLE MYELOMA BY BASELINE CYTOGENETIC RISK STATUS (PHASE 3 ENDEAVOR STUDY)

Roman Hájek

Year: 2016

abstract in proceedings

CARFILZOMIB AND DEXAMETHASONE VS SUBCUTANEOUS BORTEZOMIB AND DEXAMETHASONE IN PATIENTS WITH RELAPSED OR REFRACTORY MULTIPLE MYELOMA: SECONDARY ANALYSIS FROM THE PHASE 3 STUDY ENDEAVOR (NCT01568866)

Roman Hájek

Year: 2016

abstract in proceedings

Carfilzomib significantly improves the progression-free survival of high-risk patients in multiple myeloma

Herve Avet-Loiseau, Rafael Fonseca, David Siegel, Meletios A. Dimopoulus, Ivan Špička, Tomás Masszi, Roman Hájek, Laura Rosiňol, Vesselina Goranova-Marinova, Georgi Mihaylov, Vladimír Maisnar, Maria - Victoria Mateos, Michael Wang, Ruben Niesvizky, Albert Oriol, Andrzej Jakubowiak, Jiří Minarik, Antonio Palumbo, William Bensinger, Vishal Kukreti, Dina Ben-Yehuda, A. Keith Stewart, Mihaela Obreia, Philippe Moreau ... other authors

Year: 2016, Blood

journal article

CCR10/CCL27 crosstalk contributes to failure of proteasomeinhibitors in multiple myeloma

Shanmugapriya Thangavadievel, Claudia Zelle-Riser, Angelika Olivier, Benno Postert, Gerold Untergasser, Johann Kern, Andrea Brunner, Eberhard Gunsilius, Rainer Biedermann, Roman Hájek, Ludek Pour, Wolfgang Willenbacher, Richard Greil, Karin Johrer ... other authors

Year: 2016, ONCOTARGET

journal article

Centrosome amplification and clonal evolution in multiple myeloma: Short review

Elena Kryukova, Fedor Kryukov, Roman Hájek

Year: 2016, CRIT REV ONCOL HEMAT

journal article

Centrosome associated genes pattern for risk sub-stratification in multiple myeloma

Fedor Kryukov, P. Nemec, L. Radova, Elena Kryukova, S. Okubote, J. Minarik, Z. Stefanikova, L. Pour, Roman Hájek ... other authors

Year: 2016, J TRANSL MED

journal article

CIRCULATING SERUM MIRNA PROFILE IN AL AMYLOIDOSIS

Elena Kryukova, Kateřina Growková, Jana Filipová, Fedor Kryukov, Roman Hájek

Year: 2016

abstract in proceedings

Clonal cytogenetics changes in progression of multiple myeloma to extramedullary relapse and plasmocellular leukemia: a case report

Jan Smetana, Petr Kuglik, Henrieta Greslikova, Renata Kupska, Pavel Nemec, Aneta Mikulasova, Iveta Valaskova, Jan Oppelt, Martina Almasi, Marta Krejci, Zdenek Adam, Ludek Pour, Roman Hájek ... other authors

Year: 2016, INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY

journal article

Cytogenetics in multiple myeloma patients progressing into extramedullary disease

Lenka Besse, Lenka Sedlarikova, Henrieta Greslíková, Renata Kupska, Martina Almasi, Miroslav Penka, Tomáš Jelínek, Luděk Pour, Zdeněk Adam, Petr Kuglik, Marta Krejci, Roman Hájek, Sabina Ševčíková ... other authors

Year: 2016, EUR J HAEMATOL

journal article

Does AL amyloidosis have a unique genomic profile? Gene expression profiling meta-analysis and literature overview

Fedor Kryukov, Elena Kryukova, Lucie Brožová, Zuzana Kufová, Jana Filipová, Kateřina Growková, Tereza Ševčíková, Jiří Jarkovský, Roman Hájek ... other authors

Year: 2016, GENE

journal article

Final overall survival results of a randomized trial comparing bortezomib plus pegylated liposomal doxorubicin with bortezomib alone in patients with relapsed or refractory multiple myeloma

Robert Z. Orlowski, Arnon Narger, Pieter Sonneveld, Joan Bladé, Roman Hájek, Andrew Spencer, Tadeusz Robak, Anna Dmoszynska, Noemi Horvath, Ivan Spicka, Heather J. Sutherland, Alexander N. Suvorov, Liang Xiu, Andrew Cakana, Trilok Parekh, Jesus F. San-Miguel ... other authors

Year: 2016, CANCER

journal article

Genomewide profiling of copy-number alteration in monoclonal gammopathy of undetermined significance

Aneta Mikulášová, J. Smetana, M. Wayhelova, H. Janyskova, V. Sandecka, Zuzana Kufová, M. Almasi, J. Jarkovsky, E. Gregora, P. Kessler, M. Wrobel, B.A. Walker, CH. P. Wardell, G.J. Morgan, Roman Hájek, P. Kuglik ... other authors

Year: 2016, EUR J HAEMATOL

journal article

A. Keith Stewart, MeletiosA. Dimopoulos, Tamás Masszi, Ivan Špička, Albert Oriol, Roman Hájek ... other authors

Year: 2016, J CLIN ONCOL

journal article

Chronická lymfocytární leukemie -současné možnosti léčby

J. Zuchnická, J. Fečková Mihalyová, Roman Hájek

Year: 2016, Remedia

journal article

Ibrutinib v hematoonkologii

Jana Fečková Mihályová, Juraj Ďuraš, Jana Zuchnická, Michal Kaščák, Roman Hájek

Year: 2016, Klinická Farmakologie a Farmacie

journal article

Immunomodulatory drugs in AL amyloidosis

Tomáš Jelínek, Zuzana Kufová, Roman Hájek

Year: 2016, CRIT REV ONCOL HEMAT

journal article

Léčba starší nemocné s chronickou lymfocytární leukemií kombinací obinutuzumab a chlorambucil.

J. Zuchnická, J. Fečková Mihalyová, Roman Hájek

Year: 2016, Acta medicinae

journal article

Monoclonal antibodies - A new era in the treatment of multiple myeloma.

Tomáš Jelínek, Roman Hájek

Year: 2016, Blood reviews

journal article

Nové inovativní léky v léčbě mnohočetného myelomu.

Lenka Zahradová, Hana Plonková, Kristina Grácová, Roman Hájek

Year: 2016, Remedia

journal article

Triplet vs doublet lenalidomide-containing regimens for the treatment of elderly patients with newly diagnosed multiple myeloma

Valeria Magarotto, Sara Bringhen, Massimo Offidani, Giulia Benevolo, Francesca Patriarca, Roberto Mina, Antonietta Pia Falcone, Lorenzo De Paoli, Giuseppe Piatrantuono, Silvia Gentili, Caterina Musolino, Nicola Giuliani, Annalisa Bernardini, Concetta Conticello, Stefano Pulini, Giovannino Ciccone, Vladimír Maisnar, Marina Ruggeri, Renato Zambello, Tommasina Guglielmelli, Antonio Ledda, Anna Marina Liberati, Vittorio Montefusco, Roman Hájek, Mario Boccadoro, Antonio Palumbo ... other authors

Year: 2016, BLOOD

journal article

Waldenströmova makroglobulinémie v roce 2016: optimalizace imunochemoterapie s cílem minimalizace nežádoucích účinků

Michal Kaščák, Zuzana Kufová, Kateřina Growková, Roman Hájek

Year: 2016, Onkologia pre prax

journal article

Whole genome amplification effect on segmental copy-number changes and copy-number neutral loss of heterozygosity analysis by oligonucleotide-based array-comparative genomic hybridization in human myeloma cell line

Aneta Mikulášová, Jan Smetana, Markéta Wayhelová, Helena Janyskova, Samuel A Okubote, Roman Hájek, Petr Kuglik ... other authors

Year: 2016, INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY

journal article

Analysis of B-cell subpopulations in monoclonal gammopathies

Pavla Všianská, Lucie Říhová, Tamara Varmužová, Renata Suská, Fedor Kryukov, Aneta Mikulášová, Renata Kupská, Miroslav Penka, Luděk Pour, Zdeněk Adam, Roman Hájek ... other authors

Year: 2015, Clinical Lymphoma, Myeloma and Leukemia

journal article

Bortezomib, thalidomide and dexamethasone, with or without cyclophosphamide, for patients with previously untreated multiple myeloma: 5-year follow-up

Heinz Ludwig, Richard Greil, Tamas Masszi, Ivan Spicka, Ofer Shpilberg, Roman Hájek, Anna Dmoszynská, Bruno Paiva, María Belén Vidriales, Graca Esteves, Anne Marie Stoppa, Don Robinson, Jr., Shalini Chaturvedi, Ozlem Ataman, Christopher Enny, Huaibao Feng, Helgi van de Velde, Luisa Viterbo ... other authors

Year: 2015, BRIT J HAEMATOL

journal article

Carfilzomib, Lenalidomide, and Dexamethasone for Relapsed Multiple Myeloma

A.Keith Stewart,M.B., S. Vincent Rajkumar, Meletios A. Dimopoulos, Tamas Masszi, Ivan Špička, Ph.D., Albert Oriol, Roman Hájek, Laura Rosiňol, Ph.D, David S. Siegel, Georgi G. Mihaylov, Vesselina Giranova-Marinová, Péter Rajnics, Aleksandr Suvorov, Ruben Niesvizky, Andrej J. Jakubowiak, Jesus F. San-Miguel, Heinz Ludwig, Michael Wang, Vladimír Maisnar, Jiří Minařík, Wiliam I. Bensinger, Mária-Victoria Mateos, Dina Ben-Yehuda, Vishal Kukreti, Naseem Zojwalla, Margaret E. Tonda, Xinqun Yang, Biao Xing, Philippe Moreau, Antonio Palumbo ... other authors

Year: 2015, NEW ENGL J MED

journal article

Circulating Serum MicroRNA-130a as a Novel Putative Marker of Extramedullary Myeloma

Lenka Besse, Lenka Sedlaříková, Fedor Kryukov, Jana Nekvidová, Lenka Radová, Ondřej Slabý, Petr Kuglik, Martina Almasi, Miroslav Penka, Marta Krejčí, Zdeněk Adam, Luděk Pour, Sabina Ševčíková, Roman Hájek ... other authors

Year: 2015, PLOS ONE

journal article

Combination of serum microRNA-320a and microRNA-320b as a marker for Waldenström macroglobulinemia

Lenka Kubiczkova Besse, Lenka Sedlarikova, Fedor Kryukov, Jana Nekvindova, Lenka Radova, Martina Almasi, Jana Pelcova, Jiri Minarik, Tomas Pika, Zuzana Pikalova, Vlastimil Scudla, Marta Krejci, Zdenek Adam, Ludek Pour, Roman Hájek, Sabina Sevcikova ... other authors

Year: 2015, American Journal of Hematology

journal article

Continuous Therapy Versus Fixed Duration of Therapy in Patients With Newly Diagnosed Multiple Myeloma

Antonio Palumbo, Francesca Gay, Federica Cavallo, Francesco Di Raimondo, Alessandra Larocca, Izhar Hardan, Arnon Nagler, Maria T. Petrucci, Roman Hájek, Sara Pezzatti, Michel Delforge, Francesca Patriarca, Francesca Donato, Chiara Cerrato, Chiara Nozzoli, Zhinuan Yu, Luana Boccadifuoco, Tommaso Caravita, Giulia Benevolo, Tommasina Guglielmelli, Donatella Vincelli, Christian Jacques, Meletios A. Dimopoulos, Giovannino Ciccone, Pellegrino Musto, Paolo Corradini, Michele Cavo, Mario Boccadoro ... other authors

Year: 2015, J CLIN ONCOL

journal article

European Myeloma Network. European Myeloma Network Guidelines for the Management of Multiple Myeloma-related Complications

Evangelos Terpos, Martin Kleber, Monika Engelhardt, Sonja Zweegman, Francesca Gay, Efstathios Kastritis, Niels W.C.J. van de Donk, Benedetto Bruno, Orthan Sezer, Annemiek Broijl, Sara Bringhen, Meral Beksac, Alessandra Larocca, Roman Hájek, Pellegrino Musto, Hans Erik Johnsen, Fortunato Morabito, Heinz Ludwig, Michele Cavo, Hermann Einsele, Pieter Sonneveld, Meletion A. Dimopoulos, Antonio Palumbo ... other authors

Year: 2015, HAEMATOL-HEMATOL J

journal article

Extramedullary relapse of multiple myeloma defined as the highest risk group based on deregulated gene expression data

Sabina Ševčíková, Helena Paszeková, Lenka Besse, Lenka Sedlariková, Veronika Kubaczková, Martina Almasi, Luděk Pour, Roman Hájek ... other authors

Year: 2015, BIOMEDICAL PAPERS-OLOMOUC

journal article

Flow cytometry in immunoglobulin light chain amyloidosis: Short review

Jana Filipová, Lucie Řihová, Pavla Vsianská, Zuzana Kufová, Elena Kryukova, Fedor Kryukov, Roman Hájek ... other authors

Year: 2015, LEUKEMIA RES

journal article

Geriatric assessment predicts survival and toxicities in elderly myeloma patients: an International Myeloma Working Group report

Antonio Palumbo, Sara Bringhen, Maria-Victoria Mateos, Alessandra Larocca, Thierry Facon, Shaji K. Kumar, Massimo Offidani, Philip McCarthy, Andrea Evangelista, Sagar Lonial, Sonja Zweegman, Pellegrino Musto, Evangelos Terpos, Andrew Belch, Roman Hájek, Heinz Ludwig, A. Keith Stewart, Philippe Moreau, Kenneth Anderson, Hermann Einsele, Brian G. M. Durie, Meletios A. Dimopoulos, Ola Landgren, Jesus F. San Miguel, Paul Richardson, Pieter Sonneveld, S. Vincent Rajkumar ... other authors

Year: 2015, BLOOD

journal article

Hereditární amyloidózy - etiologie, klinický obraz a léčba

Zuzana Kufová, T. Pika, T. Jelínek, Fedor Kryukov, Roman Hájek

Year: 2015, Transfuze a Hematologie Dnes

journal article

Chemotherapy plus lenalidomide versus autologous transplantation, followed by lenalidomide plus prednisone versus lenalidomide maintenance, in patients with multiple myeloma: a randomised, multicentre, phase 3 trial

Francesca Gay, Stefania Oliva, Maria Teresa Petrucci, Concetta Conticello, Lucio Catalano, Paolo Corradini, Agostina Siniscalchi, Valeria Magarotto, Ludek Pour, Angelo Carella, Alessandra Malfitano, Daniela Petro, Andrea Evangelista, Stefano Spada, Norbert Pescosta, Paola Omede, Philip Campbell, Anna Marina Liberati, Massimo Offidani, Roberto Ria, Stefano Pulini, Francesca Patriarca, Roman Hájek, Andrew Spencer, Mario Boccadoro, Antonio Palumbo ... other authors

Year: 2015, LANCET ONCOL

journal article

MicroRNAs in urine are not biomarkers of multiple myeloma

Lenka Sedlaříková, Lenka Bešše, Soňa Novosadová, Veronika Kubaczková, Lenka Radová, Michal Staník, Marta Krejčí, Roman Hájek, Sabina Ševčíková ... other authors

Year: 2015, Journal of Negative Results in BioMedicine

journal article

Minimal Residual Disease Detection by Droplet Digital PCR in Multiple Myeloma, Mantle Cell Lymphoma, and Follicular Lymphoma A Comparison with Real-Time PCR

Daniela Drandi, Lenka Kubiczkova-Besse, Simone Ferrero, Nadia Dani, Roberto Passera, Barbara Mantoan, Manuela Gambella, Luigia Monitillo, Elona Saraci, Paola Ghione, Elisa Genuardi, Daniela Barbero, Paola Omede, Davide Barberio, Roman Hájek, Umberto Vitolo, Antonio Palumbo, Sergio Cortelazzo, Mario Boccadoro, Giogio Inghirami, Marco Ladetto ... other authors

Year: 2015, J MOL DIAGN

journal article

Plasma cell leukemia: from biology to treatment

Tomáš Jelínek, Fedor Kryukov, Lucie Říhová, Roman Hájek

Year: 2015, EUR J HAEMATOL

journal article

Subcutaneous Bortezomib in Multiple Myeloma Patients Induces Similar Therapeutic Response Rates as Intravenous Application But It Does Not Reduce the Incidence of Peripheral Neuropathy

Jiří Minarik, Petr Pavlicek, Luděk Pour, Tomáš Pika, Vladimír Maisnar, Ivan Spicka, Jiří Jarkovský, Marta Krejci, Jaroslav Bacovský, Jakub Radocha, Jan Straub, Petr Kessler, Marek Wrobel, Lenka Walterova, Michal Sykora, Jarmila Obernauerova, Lucie Brozova, Evzen Gregora, Dagmar Adamova, Jaromir Gumulec, Zdenek Adam, Vladimir Scudla, Roman Hájek ... other authors

Year: 2015, PLOS ONE

journal article

Circulating serum microRNAs as novel diagnostic and prognostic biomarkers for multiple myeloma and monoclonal gammopathy of undetermined significance

Lenka Kubiczkova, Fedor Kryukov, Ondrej Slaby, Elena Dementyeva, Jiri Jarkovsky, Jana Nekvindova, Lenka Radova, Henrieta Greslikova, Petr Kuglik, Eva Vetesnikova, Ludek Pour, Zdenek Adam, Sabina Sevcikova, Roman Hájek ... other authors

Year: 2014, Haematologica

journal article

Detekce hereditárních amyloidóz

Zuzana Kufová, Zuzana Ševčíková, Roman Hájek

Year: 2014, Klinická biochemie a metabolismus

journal article

European Myeloma Network recommendations on the evaluation and treatment of newly diagnosed patients with multiple myeloma

Monika Engelhardt, Evangelos Terpos, Martina Kleber, Francesca Gay, Ralph Wäsch, Gareth Morgan, Michele Cavo, Niels van de Donk, Andreas Beilhack, Benedetto Bruno, Hans Erik Johnsen, Roman Hájek, Christoph Driessen, Heinz Ludwig, Meral Beksac, MArio Boccadoro, Christian Straka, Sara Brighen, Martin Gramatzki, Alessandra Larocca, Henk Lokhorst, Valeria Magarotto, Fortunato Morabito, Meletios A. Dimopoulos, Hermann Einsele, Pieter Sonneveld, Antonio Palumbo ... other authors

Year: 2014, Haematologica

journal article

European Perspective on Multiple Myeloma Treatment Strategies in 2014

Heinz Ludwig, Pieter Sonneveld, Faith Davies, Joan Blade, Mario Boccadoro, Michele Cavo, Gareth Morgan, Javier de la Rubia, Michel Delforge, Meletios Dimopoulos, Hermann Einsele, Thierry Facon, Hartmut Goldschmidt, Philippe Moreau, Hareth Nahi, Torben Plesner, Jesus San-Miguel, Roman Hájek, Pia Sondergeld, Antonio Palumbo ... other authors

Year: 2014, Oncologist

journal article

Factors that influence health-related quality of life in newly diagnosed patients with multiple myeloma aged >= 65 years treated with melphalan, prednisone and lenalidomide followed by lenalidomide maintenance: results of a randomized trial

Meletios A. Dimopoulos, Antonio Palumbo, Roman Hájek, Martin Kropff, Maria Teresa Petrucci, Philip Lewis, Stefanie Millar, Jingshan Zhang, Jay Mei, Michel Delforge ... other authors

Year: 2014, Leukemia & Lymphoma

journal article

Genome-Wide Screening of Cytogenetic Abnormalities in Multiple Myeloma Patients Using Array-CGH Technique: A Czech Multicenter Experience

Jan Smetana, Jan Frohlich, Romana Zaoralova, Vladimira Vallova, Henrieta Greslikova, Renata Kupska, Pavel Nemec, Aneta Mikulasova, Martina Almasi, Ludek Pour, Zdenek Adam, Viera Sandecka, Lenka Zahradová, Roman Hájek, Petr Kuglik ... other authors

Year: 2014, BIOMED RESEARCH INTERNATIONAL

journal article

Heterogenita a plasticita mnohočetného myelomu, aneb existuje skutečně myelomová kmenová buňka?

H. Šváchová, S. Okubote, Roman Hájek

Year: 2014

abstract in proceedings

International Myeloma Working Group Consensus Statement for the Management, Treatment, and Supportive Care of Patients With Myeloma Not Eligible for Standard Autologous Stem-Cell Transplantation

Antonio Palumbo, S. Vincent Rajkumar, Jesus F. San Miguel, Alessandra Larocca, Ruben Niesvizky, Gareth Morgan, Ola Landgren, Roman Hájek, Hermann Einsele, Kenneth C. Anderson, Meletios A. Dimopoulos, Paul G. Richardson, Michele Cavo, Andrew Spencer, A. Keith Stewart, Kazuyuki Shimizu, Sagar Lonial, Pieter Sonneveld, Brian G.M. Durie, Philippe Moreau, Robert Z. Orlowski ... other authors

Year: 2014, Journal of Clinical Oncology

journal article

International Myeloma Working Group recommendations for global myeloma care

H. Ludwig, JS Miguel, MA Dimopoulos, A Palumbo, R Garcia Sanz, R Powles, S Lentzsch, W Ming Chen, J Hou, A Jurczyszyn, K Romeril, Roman Hájek, E Terpos, K Shimizu, D Joshua, V Hungria, A Rodriguez Morales, D Ben-Yehuda, P Sondergeld, E Zamagni, B Durie ... other authors

Year: 2014, Leukemia

journal article

Management of Surgical Procedures in Patients with Inherited F VII Deficiency: Six Years of Experience

Radomira Hrdlickova, Sarka Blahutova, Roman Hájek, Zuzana Čermáková

Year: 2014, Journal of Blood Disorders & Transfusion

journal article

Nestin expression throughout multistep pathogenesis of multiple myeloma

Hana Svachova, Fedor Kryukov, Elena Kryukova, Sabina Sevcikova, Pavel Nemec, Henrieta Greslikova, Lucie Rihova, Lenka Kubiczkova, Roman Hájek ... other authors

Year: 2014, British Journal of Haematology

journal article

Proteasome inhibitors - molecular basis and current perspectives in multiple myeloma

Lenka Kubiczkova, Ludek Pour, Lenka Sedlarikova, Roman Hájek, Sabina Sevcikova

Year: 2014, Journal of Cellular and Molecular Medicine

journal article

Second primary malignancies with lenalidomide therapy for newly diagnosed myeloma: a meta-analysis of individual patient data

Antonio Palumbo, Sara Bringhen, Shaji K. Kumar, Giulia Lupparelli, Saad Usmani, Anders Waage, Alessandra Larocca, Bronno van der Holt, Pellegrino Musto, Massimo Offidani, Maria T Petrucci, Andrea Evangelista, Sonja Zweegman, Ajay K Nooka, Andrew Spencer, Meletios A Dimopoulos, Roman Hájek, Michele Cavo, Paul Richardson, Sagar Lonial, Giovannino Ciccone, Mario Boccadoro, Kenneth Anderson, Bart Barlogie, Pieter Sonneveld, Philip L McCarthy ... other authors

Year: 2014, LANCET ONCOL

journal article

Soft-tissue extramedullary multiple myeloma prognosis is significantly worse in comparison to bone-related extramedullary relapse

Ludek Pour, Sabina Sevcikova, Henrieta Greslikova, Renata Kupska, Petra Majkova, Lenka Zahradova, Viera Sandecka, Zdenek Adam, Marta Krejci, Petr Kuglik, Roman Hájek ... other authors

Year: 2014, Haematologica

journal article

The clinical relevance and management of monoclonal gammopathy of undetermined significance and related disorders: recommendations from the European Myeloma Network

Niels W. C. J. van de Donk, Antonio Palumbo, Hans Erik Johnsen, Monika Engelhardt, Francesca Gay, Henrik Gregersen, Roman Hájek, Martina Kleber, Heinz Ludwig, Gareth Morgan, Pellegrino Musto, Torben Plesner, Orhan Sezer, Evangelos Terpos, Anders Waage, Sonja Zweegman, Hermann Einsele, Pieter Sonneveld, Henk M. Lokhorst ... other authors

Year: 2014, Haematologica

journal article

The role of histone deacetylase inhibitors in patients with relapsed/refractory multiple myeloma

Roman Hájek, David Siegel, Robert Z. Orlowski, Heinz Ludwig, Antonio Palumbo, Meletios Dimopoulos ... other authors

Year: 2014, Leukemia & Lymphoma

journal article

Využití imunomodulačních léků u amyloidózy

Roman Hájek, Tomáš Jelínek

Year: 2014, Mnohočetný myelom

journal article

Diagnostika a léčba systémové AL amyloidózy

Vlastimil Ščudla, Zdeněk Adam, Roman Hájek, Marta Krejčí, Tomáš Pika, Vladimír Maisnar, Patrik Flodr, Zuzana KUFOVÁ, Pavla Látalová, Anna Potáčová, Romana Ryšavá, Ivan Špička, Martin Tichý, Pavla Všianská ... other authors

Year: 2013, Transfuze a hematologie dnes

journal article

Mnohočetný myelom

Roman Hájek, Hana Plonková, Tomáš Jelínek

Year: 2013, Acta medicinae

journal article

Myeloma stem cell concepts, heterogeneity and plasticity of multiple myeloma

Roman Hájek, Samuel A. Okubote, Hana Svachova

Year: 2013, BRIT J HAEMATOL

journal article

Plasma cell leukemia: consensus statement on diagnostic requirements, response criteria and treatment recommendations by the International Myeloma Working Group

C. Fernández de Larrea, R A. Kyle, B G M. Durie, H. Ludwig, S. Usmani, D H. Vesole, Roman Hájek, J F. San Miguel, O. Sezer, P. Sonneveld, S K. Kumar, A. Mahindra, R. Comenzo, A. Palumbo, A. Mazumber, K C. Anderson, P G. Richardson, A Z. Badros, J. Caers, M. Cavo, X. LeLeu, M A. Dimopoulos, C S. Chim, R. Schots, A. Noeul, D. Fantl, U-H. Mellqvist, O. Landgren, A. Chanan-Khan, P. Moreau, R. Fonseca, G. Merlini, J J. Lahuerta, J. Blade, R Z. Orlowski, J J. Shah ... other authors

Year: 2013, LEUKEMIA

journal article

Preclinical data and early clinical experience supporting the use of histone deacetylase inhibitors in multiple myeloma

Paul G. Richardson, Constantine S. Mitsiades, Jacob P. Laubach, Roman Hájek, Ivan Spicka, Meletios A. Dimopoulos, Philippe Moreau, David S. Siegel, Sundar Jagannath, Kenneth C. Anderson ... other authors

Year: 2013, LEUKEMIA RES

journal article

Thalidomid v léčbě mnohočetného myelomu se zaměřením na kombinaci s bortezomibem

Roman Hájek, Jaromír Gumulec

Year: 2013, Klinická onkologie

journal article

Vorinostat or placebo in combination with bortezomib in patients with multiple myeloma (VANTAGE 088): a multicentre, randomised, double-blind study

Meletios Dimopoulos, David S Siegel, Sagar Lonial, Junyuan Qi, Roman Hájek, Thierry Facon, Laura Rosinol, Catherine Williams, Hilary Blacklock, Hartmut Goldschmidt, Vania Hungia, Andrew Spencer, Antonio Palumbo, Thorsten Graef, Joseph E Eid, Jennifer Houp, Linda Sun, Scott Vuocolo, Kenneth C Anderson ... other authors

Year: 2013, LANCET ONCOL

journal article

Design and rationale of FOCUS (PX-171-011): A randomized, open-label, phase 3 study of carfilzomib versus best supportive care regimen in patients with relapsed and refractory multiple myeloma (R/R MM)

Roman Hájek, Richard Bryce, Sunhee Ro, Barbara Klencke, Heinz Ludwig

Year: 2012, BMC CANCER

journal article

Kombinovaná léčba nemocných s mnohočetným myelomem - lenalidomid

Roman Hájek, Hana Plonková

Year: 2012, Acta Medicinae

journal article

Lenalidomide, melphalan, and prednisone followed by lenalidomide maintenance improves health-related quality of life in newly diagnosed multiple myeloma patients aged 65 years or older: results of a randomized phase III trial

M. A. Dimopoulos, M. Delforge, Roman Hájek, M. Kropff, MT Petrucci, P. Lewis, A. Nixon, J. Zhang, J. Mei, A. Palumbo ... other authors

Year: 2012, Haematologica

journal article

Lenalidomid v dlouhodobé strategii léčby mnohočetného myelomu

Hana Plonková, Tomáš Jelínek, Lenka Zahradová, Roman Hájek

Year: , Mnohočetný myelom

journal article

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Abbreviation

Subject

EHEM

Haematology - internship

EHEM1

Haematology - internship

EXPER

Experimentální biologie/hematologie/onko

HEMAK

Hematologie, hematoonkologie

HEMAP

Hematologie, hematoonkologie

HEMTK

Hematoonkologie, transfuziologie

HEMTP

Hematoonkologie, transfuziologie

OBOR1

Oborová zkouška z experimentální a klini

SDZPK

Státní doktorská zkouška

SDZPP

Státní doktorská zkouška

VL4LF

Vnitřní lékařství IV. - hem., trans.lék.

YVL4L

Internal medicine IV. - hematooncology

9VL4L

Vnitřní lékařství IV. - hem., trans.lék.

OBORK

Oborová zkouška z vnitřních nemocí

OBORP

Oborová zkouška z vnitřních nemocí

SDZPK

Státní doktorská zkouška

SDZPP

Státní doktorská zkouška

VL2ZL

Vnitřní lékařství II.

VL5LF

Vnitřní lékařství V.

YVLLL

Internal Medicine - Summary Exam

YVL5L

Internal Medicine V.

9IPRL

Interní propedeutika

9VL5L

Vnitřní lékařství V.

Author

Title

Type of thesis

Year

Jelínek Tomáš

Modern immunotherapy in the treatment of multiple myeloma and acute myeloid leukemia

Doctoral thesis

2020

Filipová Jana

Selection and separation of cells using flow cytometry with focusing on rare monoclonal gammapathies

Master's thesis

2015

Kočí Renáta

Options of inhibition of the mitotic spindle by modern medicaments in the blood cancer issue

Bachelor's thesis

2016

Saving lives through research in early cancer detection and prevention: Molecular, genomic and societal factors

Main solver

prof. MUDr. Roman Hájek, CSc.

Period

1/2024 - 6/2028

Provider

OP JAK (Jan Amos Komenský)

State

solved

Life Environment Research Center Ostrava

Main solver

prof. MUDr. Roman Hájek, CSc.

Period

1/2021 - 12/2027

Provider

Děkanát LF, Děkanát PdF, Děkanát PřF, OP ST (Spravedlivá transformace)

State

solved

A novel local therapy for myeloma bone disease

Main solver

prof. MUDr. Roman Hájek, CSc.

Period

5/2021 - 12/2024

Provider

Ministerstvo zdravotnictví

State

solved

Předprojektová příprava LERCO

Main solver

prof. MUDr. Roman Hájek, CSc.

Period

4/2022 - 9/2023

Provider

Lékařská fakulta, Pedagogická fakulta, Přírodovědecká fakulta, Nezařazené projekty

State

solved

WE ARE "OSTRAVSKÁ" = THE MODERN, INSPIRATIONAL AND ATTRACTIVE PLACE FOR QUALITY STUDY

Main solver

prof. MUDr. Roman Hájek, CSc.

Period

5/2017 - 6/2023

Provider

Rektorát, Operační program Výzkum, vývoj a vzdělávání (OP VVV)

State

finished

Molecular, cellular and clinical approach to healthy ageing

Main solver

prof. MUDr. Roman Hájek, CSc.

Period

9/2018 - 6/2023

Provider

Operační program Výzkum, vývoj a vzdělávání (OP VVV)

State

solved

New Directions of Biomedical Research in the Ostrava Region

Main solver

prof. MUDr. Roman Hájek, CSc.

Period

5/2019 - 12/2022

Provider

Děkanát LF, Operační program Výzkum, vývoj a vzdělávání (OP VVV)

State

in sustainability

Aberrant plasma cells clonal diversification in immunoglobulin light chain amyloidosis

Main solver

prof. MUDr. Roman Hájek, CSc.

Period

5/2015 - 12/2019

Provider

IGA MZd

State

finished

PRO-Ost

Main solver

prof. MUDr. Roman Hájek, CSc.

Period

1/2017 - 10/2019

Provider

Centrum excelence IT4Innovations, divize, Děkanát FSS, Děkanát FU, Děkanát LF, Děkanát PdF, Děkanát PřF, Rektorát, Univerzitní knihovna, Operační program Výzkum, vývoj a vzdělávání (OP VVV)

State

in sustainability

Bone Marrow Microenvironment in Multiple Myeloma: Application of 2D and 3D in vitro models using patient's specific IPSCs derived Mesenchymal Stem cells

Main solver

prof. MUDr. Roman Hájek, CSc.

Period

8/2016 - 12/2017

Provider

Katedra interních oborů, Projekty podporované z rozpočtu měst krajských úřadů

State

finished

Podpora přípravy klíčových projektů OU v operačních programech EU pro nové programovací období

Main solver

prof. MUDr. Roman Hájek, CSc.

Period

1/2015 - 12/2015

Provider

Rozvojové programy MŠMT

State

finished

Zahájení dlouhodobého výzkumu u monoklonálních gamapatií

Main solver

prof. MUDr. Roman Hájek, CSc.

Period

12/2014 - 12/2015

Provider

Lékařská fakulta, Projekty podporované z rozpočtu měst krajských úřadů

State

finished

Zavedení metody sekvenování nové generace (next generation sequencing) v rámci screeningu hereditárních amyloidóz v České republice/ Dotační titul 2

Main solver

prof. MUDr. Roman Hájek, CSc.

Period

9/2014 - 8/2015

Provider

Lékařská fakulta, Přírodovědecká fakulta, Projekty podporované z rozpočtu měst krajských úřadů

State

finished

Dynamics of microRNA and cellfree DNA profiles during multiple myeloma progression

Main solver

prof. MUDr. Roman Hájek, CSc.

Period

1/2014 - 12/2014

Provider

Ostatní projekty ze zahr. prostředků

State

finished

Zavedení a využití metody separace jednotlivých buněk pomocí imunofluorescenčních metod a následné aplikace v hematoonkologii

Main solver

prof. MUDr. Roman Hájek, CSc.

Period

10/2013 - 12/2014

Provider

Lékařská fakulta, Projekty podporované z rozpočtu měst krajských úřadů

State

finished

Roman Hájek

Basic information

CV

Publications

Teaching

Supervised theses

Projects

Another education, courses

Working Practice

Valuation

Membership

Research and professional experience

Centre for Health Research