Larissa Haertle, Natalia Buenache, Hipolito Nicolas Cuesta Hernandez, Michal Šimíček, Renáta ŠNAUROVÁ, Inmaculada Rapado, Nerea Martinez, Nieves Lopez-Munoz, Jose Maria Sanchez-Pina, Umair Munawar, Seungbin Han, Yanira Ruiz-Heredia, Rafael Colmenares, Miguel Gallardo, Margarita Sanchez-Beato, Miguel Angel Piris, Mehmet Kemal Samur, Nikhil C. Munshi, Rosa Ayala, Klaus Martin Kortum, Santiago Barrio, Joaquin Martinez-Lopez ... other authors

Year: 2023, CANCERS

journal article

Insight into the mechanism of CD34+ cell mobilisation impairment in multiple myeloma patients treated with anti-CD38 therapy

Ondřej Venglář, Veronika Kapustová, Anjana Anilkumar Sithara, David ŽIHALA, Ludmila MUROŇOVÁ, Tereza Ševčíková, Jan Vrana, Alexander Vdovin, Jakub Radocha, Petra Krhovska, Matouš Hrdinka, Michal Turjap, Tereza Popková, Zuzana Chyra, Lucie Broskevičová, Michal Šimíček, Zdeněk Kořístek, Roman Hájek, Tomáš Jelínek ... other authors

Year: 2023, BRITISH JOURNAL OF HAEMATOLOGY

journal article

Length-dependent translation efficiency of ER-destined proteins

Hana Šahinbegović, Alexander Vdovin, Renáta Šnaurová, Michal Ďurech, Jakub Nezval, Jiří Sobotka, Roman Hájek, Tomáš Jelínek, Michal Šimíček ... other authors

Year: 2023, Journal of Molecular Biology

journal article

Length-Dependent Translation Efficiency of ER-Destined Proteins

Hana Šahinbegović, Alexander Vdovin, Renáta ŠNAUROVÁ, Michal Ďurech, Jakub Nezval, J. Sobotka, Roman Hájek, Tomáš Jelínek, Michal Šimíček ... other authors

Year: 2023, Current Issues in Molecular Biology

journal article

More Than 2% of Circulating Tumor Plasma Cells Defines Plasma Cell Leukemia-Like Multiple Myeloma

Tomáš Jelínek, Renata Bezdekova, David ŽIHALA, Tereza Ševčíková, Anjana Anilkumar Sithara, Lenka Pospisilova, Sabina Sevcikova, Petra Polackova, Martin Stork, Zdenka Knechtova, Ondřej Venglář, Veronika Kapustová, Tereza Popková, Ludmila MUROŇOVÁ, Zuzana Chyra, Matouš Hrdinka, Michal Šimíček, Juan-Jose Garces, Noemi Puig, Maria-Teresa Cedena, Artur Jurczyszyn, Jorge J. Castillo, Miroslav Penka, Jakub Radocha, Maria Victoria Mateos, Jesus F. San-Miguel, Bruno Paiva, Ludek Pour, Lucie Rihova, Roman Hájek ... other authors

Year: 2023, JOURNAL OF CLINICAL ONCOLOGY

journal article

Single-Nucleotide Variants and Epimutations Induce Proteasome Inhibitor Resistance in Multiple Myeloma

Larissa Haertle, Santiago Barrio, Umair Munawar, Seungbin Han, Xiang Zhou, Michal Šimíček, Cornelia Vogt, Marietta Truger, Rafael Alonso Fernandez, Maximilian Steinhardt, Julia Weingart, Renáta ŠNAUROVÁ, Silvia Nerreter, Eva Teufel, Andoni Garitano-Trojaola, Matteo Da Via, Yanira Ruiz-Heredia, Andreas Rosenwald, Niccolo Bolli, Roman Hajek, Peter Raab, Marc S. Raab, Niels Weinhold, Claudia Haferlach, Thomas Haaf, Joaquin Martinez-Lopez, Hermann Einsele, Leo Rasche, K. Martin Kortuem ... other authors

Year: 2023, CLINICAL CANCER RESEARCH

journal article

Transcriptome Analysis of Diffuse Large B-Cell Lymphoma Cells Inducibly Expressing MyD88 L265P Mutation Identifies Upregulated CD44, LGALS3, NFKBIZ, and BATF as Downstream Targets of Oncogenic NF-κB Signaling

Marcello Turi, Anjana Anilkumar Sithara, Lucie Hofmanová, David ŽIHALA, Dhwani Radhakrishnan, Alexander Vdovin, Sofija Knápková, Tereza Ševčíková, Zuzana Chyra, Tomáš Jelínek, Michal Šimíček, Annamaria Gulla, Kenneth Carl Anderson, Roman Hájek, Matouš Hrdinka ... other authors

Year: 2023, International Journal of Molecular Sciences

journal article

Tuning CARs: recent advances in modulating chimeric antigen receptor (CAR) T cell activity for improved safety, efficacy, and flexibility

Piotr Celichowski, Marcello Turi, Sandra Charvátová, Dhwani Radhakrishnan, Neda Feizi, Zuzana Chyra, Michal Šimíček, Tomáš Jelínek, Julio Rodriguez Bago, Roman Hájek, Matouš Hrdinka ... other authors

Year: 2023, Journal of Translational Medicine

journal article

Deubiquitinase OTUD1 Resolves Stalled Translation on polyA and Rare Codon Rich mRNAs

Renáta Šnaurová, Alexander Vdovin, Michal Ďurech, Jakub Nezval, David ŽIHALA, Tomáš Jelínek, Roman Hájek, Michal Šimíček ... other authors

Year: 2022, Molecular and Cellular Biology

journal article

Limited efficacy of daratumumab in multiple myeloma with extramedullary disease

Tomáš Jelínek, Tereza Ševčíková, David ŽIHALA, Tereza Popková, Veronika Kapustová, Lucie Broskevičová, Lenka Capkova, Lucie Rihova, Renata Bezdekova, Sabina Sevcikova, Vladimir Zidlik, Martin Havel, Hana Plonkova, Alexandra Jungova, Jiri Minarik, Martin Stork, Ludek Pour, Petr Pavlicek, Ivan Spicka, Vladimir Maisnar, Jakub Radocha, Michal Šimíček, Roman Hájek ... other authors

Year: 2022, Leukemia

journal article

Mutation landscape of multiple myeloma measurable residual disease: identification of targets for precision medicine

Martina Zátopková, Tereza Ševčíková, Viola Fanfani, Zuzana Chyra, Lucie Rihova, Renata Bezdekova, David ŽIHALA, Kateřina Growková, Jana Filipová, Lucie Černá, Lucie Broskevicova, Fedor Kryukov, Jiri Minarik, Jana Smejkalova, Vladimir Maisnar, Lubica Harvanova, Ludek Pour, Alexandra Jungova, Tereza Popková, Julio Rodriguez Bago, Anjana Anilkumar Sithara, Matouš Hrdinka, Tomáš Jelínek, Michal Šimíček, Giovanni Stracquadanio, Roman Hájek ... other authors

Year: 2022, Blood Advances

journal article

The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma

Alexander Vdovin, Tomáš Jelínek, David ŽIHALA, Tereza Ševčíková, Michal Ďurech, Hana Šahinbegović, Renáta Šnaurová, Dhwani Radhakrishnan, Marcello Turi, Zuzana Chyra, Tereza Popková, Ondřej Venglář, Matouš Hrdinka, Roman Hájek, Michal Šimíček ... other authors

Year: 2022, Nature Communications

journal article

Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis

Zuzana Kufová, Tereza Ševčíková, Petr Vojta, J. Puterova, L. Brozova, Kateřina Growková, Jana Filipová, Martina Zátopková, S. Grosicki, A. Barchnicka, W. Wiktor-Jedrzejczak, A. Waszczuk-Gajda, A. Jungova, A. Mikulasova, M. Hajduch, M. Mokrejs, L. Pour, M. Stork, L. Harvanova, M. Mistrik, G. Mikala, P. Robak, A. Czyz, J. Debski, L. Usnarska-Zubkiewicz, A. Jurczyszyn, L. Stejskal, G. Morgan, Fedor Kryukov, E. Budinska, Michal Šimíček, Tomáš Jelínek, Matouš Hrdinka, Roman Hájek ... other authors

Year: 2021, HAEMATOL-HEMATOL J

journal article

Selection, Expansion, and Unique Pretreatment of Allogeneic Human Natural Killer Cells with Anti-CD38 Monoclonal Antibody for Efficient Multiple Myeloma Treatment

Benjamin Motais, Sandra Charvátová, Zuzana Walek, Matouš Hrdinka, Ryszard Smolarczyk, Tomasz Cichoń, Justyna Czapla, Sebastian Giabel, Michal Šimíček, Tereza Ševčíková, Jiří Sobotka, Zdeněk Kořístek, Roman Hájek, Julio Rodriguez Bago ... other authors

Year: 2021, Cells

journal article

A Bird's-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers

Benjamin Motais, Sandra Charvátová, Matouš Hrdinka, Michal Šimíček, Tomáš Jelínek, Tereza Ševčíková, Zdeněk Kořístek, Roman Hájek, Julio Rodriguez Bago ... other authors

Year: 2020, CANCERS

journal article

Intercellular Mitochondrial Transfer in the Tumor Microenvironment

Hana Šahinbegović, Tomáš Jelínek, Matouš Hrdinka, Julio Rodriguez Bago, Marcello Turi, Tereza Ševčíková, Amina Kurtovic-Kotaric, Roman Hájek, Michal Šimíček ... other authors

Year: 2020, Cancers

journal article

Transcriptional profiling of circulating tumor cells in multiple myeloma: a new model to understand disease dissemination

Garces Juan-Jose, Michal Šimíček, Vicari Marco, Brozova Lucie, Burgos Leire, Bezdekova Renata, Alignani Diego, Calasanz Maria-Jose, Kateřina Growková, Goicoechea Ibai, Agirre Xabier, Pour Ludek, Prosper Felipe, Rios Rafael, Martinez-Lopez Joaquin, Millacoy Pamela, Palomera Luis, Del Orbe Rafael, Perez-Montana Albert, Garate Sonia, Blanco Laura, Lasa Marta, Maiso Patricia, Flores-Montero Juan, Sanoja-Flores Luzalba, Chyra Zuzana, Alexander Vdovin, Sevcikova Tereza, Tomáš Jelínek, Botta Cirino, El Omri Halima, Keats Jonathan, Orfao Alberto, Roman Hájek, San-Miguel Jesus F., Paiva Bruno ... other authors

Year: 2020, LEUKEMIA

journal article

Venetoclax plus bortezomib and dexamethasone in heavily pretreated end-stage myeloma patients without t(11;14): A real-world cohort

Tomáš Jelínek, Popkova Tereza, Juraj Ďuraš, Jana Fečková Mihályová, Michal Kaščák, Kateřina Benková, Plonkova Hana, Lucie Černá, Zdeněk Kořístek, Michal Šimíček, Roman Hájek ... other authors

Year: 2020, HEMATOLOGICAL ONCOLOGY

journal article

Cytarabine plus G-CSF is more effective than cyclophosphamide plus G-CSF as a stem cell mobilization regimen in multiple myeloma

Roman Hájek, Tomáš Jelínek, Lucie Adamusová, Tereza Popková, Jana Smejkalová, Michal Šimíček, Dana Salounová, Michal Kaščák, Jana Mihalyová, Hana Plonková, Juraj Ďuraš, Milan Navrátil, Zdeněk Kořístek ... other authors

Year: 2019, BONE MARROW TRANSPL

journal article

Single-agent venetoclax induces MRD-negative response in relapsed primary plasma cell leukemia with t(11;14)

Roman Hájek, Tomáš Jelínek, Jana Fečková Mihályová, Juraj Ďuraš, Tereza Popková, Kateřina Benková, Hana Plonková, Jana Zuchnická, Lucie Broskevičová, Lucie Huvarová, Lucie Černá, Kateřina Growková, Michal Šimíček, Martin Havel, Jaromír Gumulec, Zdeněk Kořístek, Bruno Paiva, Petra Richterová, Milan Navrátil, Michal Kascák ... other authors

Year: 2019, AMERICAN JOURNAL OF HEMATOLOGY

journal article

Active site alanine mutations convert deubiquitinases into high-affinity ubiquitinbinding proteins

Marie E Morrow, Michael T Morgan, Marcello Clerici, Kateřina Growková, Ming Yan, David Komander, Titia K Sixma, Michal Šimíček, Cynthia Wolberger ... other authors

Year: 2018, EMBO REP

journal article

Venetoclax: A new wave in hematooncology

Jana Fečková Mihályová, Tomáš Jelínek, K. Growková, Matouš Hrdinka, Michal Šimíček, Roman Hájek ... other authors

Year: 2018, EXPERIMENTAL HEMATOLOGY

journal article

Biomarkers in immunoglobulin light chain amyloidosis

Zuzana Kufová, Tereza Ševčíková, Kateřina Growková, P. Vojta, Jana Filipová, Z. Adam, L. Pour, M. Penka, R. Rysava, P. Nemec, L. Brozova, P. Vychytilova, A. Jurczyszyn, S. Grosicki, A. Barchnicka, M. Hajduch, Roman Hájek, Michal Šimíček ... other authors

Year: 2017, Klinicka Onkologie

journal article

CRISPR in research and treatment of multiple myeloma

Michal Šimíček, Kateřina Growková, Roman Hájek

Year: 2017, Klinicka Onkologie

journal article

Current applications of multiparameter flow cytometry in plasma cell disorders

Tomáš Jelínek, R. Bezdekova, R. Zatopkova, L. Burgos, Michal Šimíček, Tereza Ševčíková, B. Paiva, Roman Hájek ... other authors

Year: 2017, BLOOD CANCER JOURNAL

journal article

Whole exome sequencing of aberrant plasma cells in a patient with multiple myeloma minimal residual disease

M. Zatopkova, Jana Filipová, Tomáš Jelínek, Tereza Ševčíková, Michal Šimíček, L. Rihova, R. Bezdekova, Kateřina Growková, Zuzana Kufová, J. Smejkalova, M. Hajduch, L. Pour, J. Minarik, A. Jungova, V. Maisnar, Fedor Kryukov, Roman Hájek ... other authors