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UO > About > Organizational Structure > Faculties & Institutes > Faculty of Medicine > Departments & Centres > Institute of Laboratory Medicine

Matouš Hrdinka


Academic degree, name, surname:
RNDr. Matouš Hrdinka, Ph.D.
Room, floor, building:
Position:
Group Leader and Scientific Lead for Translational Research
Research interests and teaching:
Department (Faculty):
Institute of Laboratory Medicine (Faculty of Medicine)
Head and Neck Cancer Research Group (Faculty of Medicine)
Phone number, mobile:
+420 702 824 006
E-mail:



No record found.



Deubiquitinase BAP1 is crucial for surface expression of T cell receptor (TCR) complex, T cell-B cell conjugate formation, and T cell activation
Dhwani Radhakrishnan, Jana Kotulová, Lucie Hofmanová, Anjana Anilkumar Sithara, Marcello Turi, David ŽIHALA, Michal Ďurech, Jan VRÁNA, Valeria Uleri, Veronika Niederlova, Stepanek Ondrej, Zuzana Chyra, Tomáš Jelínek, Roman Hájek, Matouš Hrdinka ... other authors
Year: 2025, Journal of Leukocyte Biology
journal article
 
Beyond the marrow: insights from comprehensive next-generation sequencing of extramedullary multiple myeloma tumors
Tomáš Jelínek, David ŽIHALA, Tereza Ševčíková, Anjana Anilkumar Sithara, Veronika Kapustová, Hana Šahinbegović, Ondřej Venglář, Ludmila MUROŇOVÁ, Lucie Broskevičová, Serafim Nenarokov, Daniel Bílek, Tereza Popková, H. Plonkova, Jan VRÁNA, V. Zidlik, P. Hurník, Martin Havel, Matouš Hrdinka, Zuzana Chyra, G. Stracquadanio, Michal Šimíček, Roman Hájek ... other authors
Year: 2024, LEUKEMIA
journal article
 
Beyond the marrow: insights from comprehensive nextgeneration sequencing of extramedullary multiple myeloma tumors
Tomáš Jelínek, David ŽIHALA, Tereza Ševčíková, Anjana Anilkumar Sithara, Veronika Kapustová, Hana Šahinbegović, Ondřej Venglář, Ludmila MUROŇOVÁ, Lucie Broskevičová, Serafim Nenarokov, Daniel Bílek, Tereza Popková, H. Plonková, Jan VRÁNA, Vladimír Židlík, Pavel Hurník, Martin Havel, Matouš Hrdinka, Zuzana Chyra, G. Stracquadanio, Michal Šimíček, Roman Hájek ... other authors
Year: 2024, Leukemia
journal article
 
Insight into the mechanism of CD34+ cell mobilisation impairment in multiple myeloma patients treated with anti-CD38 therapy
Ondřej Venglář, Veronika Kapustová, Anjana Anilkumar Sithara, David ŽIHALA, Ludmila MUROŇOVÁ, Tereza Ševčíková, Jan Vrana, Alexander Vdovin, Jakub Radocha, Petra Krhovska, Matouš Hrdinka, Michal Turjap, Tereza Popková, Zuzana Chyra, Lucie Broskevičová, Michal Šimíček, Zdeněk Kořístek, Roman Hájek, Tomáš Jelínek ... other authors
Year: 2024, BRITISH JOURNAL OF HAEMATOLOGY
journal article
 
More Than 2% of Circulating Tumor Plasma Cells Defines Plasma Cell Leukemia-Like Multiple Myeloma
Tomáš Jelínek, Renata Bezdekova, David ŽIHALA, Tereza Ševčíková, Anjana Anilkumar Sithara, Lenka Pospisilova, Sabina Sevcikova, Petra Polackova, Martin Stork, Zdenka Knechtova, Ondřej Venglář, Veronika Kapustová, Tereza Popková, Ludmila MUROŇOVÁ, Zuzana Chyra, Matouš Hrdinka, Michal Šimíček, Juan-Jose Garces, Noemi Puig, Maria-Teresa Cedena, Artur Jurczyszyn, Jorge J. Castillo, Miroslav Penka, Jakub Radocha, Maria Victoria Mateos, Jesus F. San-Miguel, Bruno Paiva, Ludek Pour, Lucie Rihova, Roman Hájek ... other authors
Year: 2023, JOURNAL OF CLINICAL ONCOLOGY
journal article
 
Transcriptome Analysis of Diffuse Large B-Cell Lymphoma Cells Inducibly Expressing MyD88 L265P Mutation Identifies Upregulated CD44, LGALS3, NFKBIZ, and BATF as Downstream Targets of Oncogenic NF-κB Signaling
Marcello Turi, Anjana Anilkumar Sithara, Lucie Hofmanová, David ŽIHALA, Dhwani Radhakrishnan, Alexander Vdovin, Sofija Knápková, Tereza Ševčíková, Zuzana Chyra, Tomáš Jelínek, Michal Šimíček, Annamaria Gulla, Kenneth Carl Anderson, Roman Hájek, Matouš Hrdinka ... other authors
Year: 2023, International Journal of Molecular Sciences
journal article
 
Tuning CARs: recent advances in modulating chimeric antigen receptor (CAR) T cell activity for improved safety, efficacy, and flexibility
Piotr Celichowski, Marcello Turi, Sandra Charvátová, Dhwani Radhakrishnan, Neda Feizi, Zuzana Chyra, Michal Šimíček, Tomáš Jelínek, Julio Rodriguez Bago, Roman Hájek, Matouš Hrdinka ... other authors
Year: 2023, Journal of Translational Medicine
journal article
 
Mutation landscape of multiple myeloma measurable residual disease: identification of targets for precision medicine
Martina Zátopková, Tereza Ševčíková, Viola Fanfani, Zuzana Chyra, Lucie Rihova, Renata Bezdekova, David ŽIHALA, Kateřina Growková, Jana Filipová, Lucie Černá, Lucie Broskevicova, Fedor Kryukov, Jiri Minarik, Jana Smejkalova, Vladimir Maisnar, Lubica Harvanova, Ludek Pour, Alexandra Jungova, Tereza Popková, Julio Rodriguez Bago, Anjana Anilkumar Sithara, Matouš Hrdinka, Tomáš Jelínek, Michal Šimíček, Giovanni Stracquadanio, Roman Hájek ... other authors
Year: 2022, Blood Advances
journal article
 
The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma
Alexander Vdovin, Tomáš Jelínek, David ŽIHALA, Tereza Ševčíková, Michal Ďurech, Hana Šahinbegović, Renáta Šnaurová, Dhwani Radhakrishnan, Marcello Turi, Zuzana Chyra, Tereza Popková, Ondřej Venglář, Matouš Hrdinka, Roman Hájek, Michal Šimíček ... other authors
Year: 2022, Nature Communications
journal article
 
Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis
Zuzana Kufová, Tereza Ševčíková, Petr Vojta, J. Puterova, L. Brozova, Kateřina Growková, Jana Filipová, Martina Zátopková, S. Grosicki, A. Barchnicka, W. Wiktor-Jedrzejczak, A. Waszczuk-Gajda, A. Jungova, A. Mikulasova, M. Hajduch, M. Mokrejs, L. Pour, M. Stork, L. Harvanova, M. Mistrik, G. Mikala, P. Robak, A. Czyz, J. Debski, L. Usnarska-Zubkiewicz, A. Jurczyszyn, L. Stejskal, G. Morgan, Fedor Kryukov, E. Budinska, Michal Šimíček, Tomáš Jelínek, Matouš Hrdinka, Roman Hájek ... other authors
Year: 2021, HAEMATOL-HEMATOL J
journal article
 
Selection, Expansion, and Unique Pretreatment of Allogeneic Human Natural Killer Cells with Anti-CD38 Monoclonal Antibody for Efficient Multiple Myeloma Treatment
Benjamin Motais, Sandra Charvátová, Zuzana Walek, Matouš Hrdinka, Ryszard Smolarczyk, Tomasz Cichoń, Justyna Czapla, Sebastian Giabel, Michal Šimíček, Tereza Ševčíková, Jiří Sobotka, Zdeněk Kořístek, Roman Hájek, Julio Rodriguez Bago ... other authors
Year: 2021, Cells
journal article
 
A Bird's-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers
Benjamin Motais, Sandra Charvátová, Matouš Hrdinka, Michal Šimíček, Tomáš Jelínek, Tereza Ševčíková, Zdeněk Kořístek, Roman Hájek, Julio Rodriguez Bago ... other authors
Year: 2020, CANCERS
journal article
 
Intercellular Mitochondrial Transfer in the Tumor Microenvironment
Hana Šahinbegović, Tomáš Jelínek, Matouš Hrdinka, Julio Rodriguez Bago, Marcello Turi, Tereza Ševčíková, Amina Kurtovic-Kotaric, Roman Hájek, Michal Šimíček ... other authors
Year: 2020, Cancers
journal article
 
Systematic analysis of the IL-17 receptor signalosome reveals a robust regulatory feedback loop
Draberova Helena, Janusova Sarka, Knizkova Daniela, Semberova Tereza, Pribikova Michaela, Ujevic Andrea, Harant Karel, Sofija Knápková, Matouš Hrdinka, Fanfani Viola, Stracquadanio Giovanni, Drobek Ales, Ruppova Klara, Stepanek Ondrej, Draber Peter ... other authors
Year: 2020, Embo Journal
journal article
 
Inhibitor of apoptosis proteins in human health and disease
Matouš Hrdinka, Monica Yabal
Year: 2019, Genes & Immunity
journal article
 
Venetoclax: A new wave in hematooncology
Jana Fečková Mihályová, Tomáš Jelínek, K. Growková, Matouš Hrdinka, Michal Šimíček, Roman Hájek ... other authors
Year: 2018, EXPERIMENTAL HEMATOLOGY
journal article
 

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Author
Title
Type of thesis
Year
Radhakrishnan Dhwani
Comprehensive analysis of ubiquitination in immune signaling
Doctoral thesis
2024
Turi Marcello
Analysis of Ubiquitin System in Oncogenic Signaling in Blood Cancer
Doctoral thesis
2023
Neuwirthová Jana
.
Master's thesis
2022
Hanáček Damian
Analysis of the Therapeutic Potential of iNKT Cells in the Context of Multiple Myeloma
Bachelor's thesis
2024
Warmusová Sandra
Deubiquitinating enzymes in haematological malignancies
Bachelor's thesis
2019



National centre for new methods of diagnosis, monitoring, treatment and prevention of genetic diseases
Period
1/2023 – 12/2028
Provider
Technologická agentura ČR
State
solved
Role in the project
Principal Investigator
Total costs
68 533 320 CZK
 
Saving lives through research in early cancer detection and prevention: Molecular, genomic and societal factors
Period
1/2024 – 6/2028
Provider
OP JAK (Jan Amos Komenský)
State
solved
Role in the project
Co-Investigator
Total costs
48 179 516,18 CZK
 
Complex Panel for Monoclonal Gammopathies Genetic Screening
Period
1/2024 – 12/2025
Provider
Technologická agentura ČR
State
solved
Role in the project
Co-Investigator
Total costs
5 000 000 CZK
 
Research of molecular basis of hematological malignancies and novel biomarkers for targeted cell therapy
Period
1/2023 – 12/2023
Provider
Specifický VŠ výzkum
State
finished
Role in the project
Principal Investigator
Total costs
931 322 CZK
 
Analysis of selected cellular signaling pathways responsible for pathogenesis and drug resistance in hematological malignancies
Period
1/2022 – 12/2022
Provider
Specifický VŠ výzkum
State
finished
Role in the project
Co-Investigator
Total costs
630 000 CZK
 
New Directions of Biomedical Research in the Ostrava Region
Period
5/2019 – 12/2022
Provider
Děkanát LF, Operační program Výzkum, vývoj a vzdělávání (OP VVV)
State
in sustainability
Role in the project
Co-Investigator
Total costs
18 399 976 CZK
 
Center for Cell Therapy in Hematologic Malignancies
Period
1/2018 – 12/2020
Provider
Rozvojové programy MŠMT
State
finished
Role in the project
Co-Investigator
Total costs
7 955 000 CZK
 
Molecular characterization of newly identified protein markers in residual multiple myeloma resistant to antitumor therapy
Period
1/2019 – 12/2020
Provider
Specifický VŠ výzkum
State
finished
Role in the project
Co-Investigator
Total costs
887 000 CZK
 

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