Projects & Grants
| Prospective multicenter validation of the protocol for the noninvasive diagnostics of acute myocarditis with chest pain (infarct-like myocarditis) | |
|---|---|
| Project Id | NW25-02-00206 |
| Main solver | prof. MUDr. Jan Václavík, Ph.D., FESC, FEFIM, MHA |
| Period | 5/2025 - 12/2028 |
| Provider | Agentura zdravotnického výzkumu ČR |
| State | solved |
| Anotation | Acute myocarditis is an inflammatory disease of the myocardium that arises in response to infectious Project Proposal: NW25-02-00206 4/40 pathogens, toxins, drugs or autoimmune diseases. Many patients present with chest pain and a course similar to acute myocardial infarction. These patients usually have mild impairment of left ventricular systolic function and a good prognosis. Because patients present with chest pain, ECG changes and troponin positivity, approximately 80% of them undergo invasive coronary angiography to exclude obstructive coronary artery disease. These examinations burden the patients with the risk of complications, contrast agent administration and radiation exposure. Based on the pilot project results, an algorithm for non-invasive identification of patients with acute myocarditis was developed at the University Hospital Brno based on ECG, echocardiography and laboratory testing of hs-troponin, CRP and copeptin. While patients with myocardial infarction have low CRP and high copeptin values in the acute phase, patients with acute myocarditis have higher CRP and low copeptin values on admission.This project hypothesises that 70-80% of myocarditis with chest pain could be diagnosed non-invasively with a specificity of 100%; that is, acute coronary angiography would not be needed in these patients. |
