Projects & Grants
| Detailed assessment of gastric functions in patients with diabetes mellitus | |
|---|---|
| Project Id | NW24-06-00121 |
| Main solver | doc. Mgr. Marek Bužga, Ph.D. |
| Period | 5/2024 - 12/2027 |
| Provider | Agentura zdravotnického výzkumu ČR |
| State | solved |
| Anotation | Gastric function in patients with diabetes is not well understood. These patients often present with upper gastrointestinal symptoms (early satiety, abdominal fullness, bloating, nausea and vomiting). Some patients suffer from gastroparesis (GP), which is characterized by symptoms and delayed gastric emptying. Diabetic GP may be debilitating disease as it increases mortality. Treatment of both GP and dyspeptic symptoms in patients with diabetes is challenging, partly because of complex and incompletely understood pathophysiology. Two main mechanisms are believed to be responsible for development of gastroparesis/dyspepsia ? gastric hypomotility and pyloric dysfunction. In this project, we plan to prospectively assess several gastric functions in patients with diabetes (n=100, type I and II) and to elucidate mechanisms responsible for development of dyspepsia and/or GP. The assessment will be performed twice in 12 (?3) months to track changes over time; to see, for example, whether patients progress from no dyspepsia to gastroparesis. We will assess symptoms, quality of life, blood tests, gastric motor function (electrogastrography), autonomic function (heart rate variability), gastric emptying (scintigraphy) and pyloric function (pyloric distensibility). The results of all tests will be correlated with each other, including an assessment of the type and severity of diabetes and their effect on selected gastric functions. The results will lead to better understanding of gastric pathophysiology in patients with diabetes, which may help in applying individualized treatment approach (depending on the type of dysfunction) in diabetic patients with dyspepsia/GP. Control group (n=20) will be assessed just once. This project builds on our prospective study, in which we have shown that endoscopic pyloromyotomy is effective in 71% of patients (compared to 22% in ?placebo? group) with gastroparesis, diabetic in particular (Martinek et al., Gut 2022). |
