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UO > About > Organizational Structure > Faculties & Institutes > Faculty of Medicine > Departments & Centres > Department of Hematooncology

Michal Šimíček


Academic degree, name, surname:doc. RNDr. Michal Šimíček, PhD.
Room, floor, building:
Position:Head of Department
Research interests and teaching:
Department (Faculty): Department of Haematooncology (Faculty of Medicine)
Department of Biology and Ecology (Faculty of Science)
Medical Research Center (Faculty of Medicine) (Faculty of Medicine)
Phone number, mobile:
E-mail:



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Limited efficacy of daratumumab in multiple myeloma with extramedullary disease
Tomáš Jelínek, Tereza Ševčíková, David ŽIHALA, Tereza Popková, Veronika Kapustová, Lucie Broskevičová, Lenka Capkova, Lucie Rihova, Renata Bezdekova, Sabina Sevcikova, Vladimir Zidlik, Martin Havel, Hana Plonkova, Alexandra Jungova, Jiri Minarik, Martin Stork, Ludek Pour, Petr Pavlicek, Ivan Spicka, Vladimir Maisnar, Jakub Radocha, Michal Šimíček, Roman Hájek ... other authors
Year: 2022, Leukemia
journal article

Mutation landscape of multiple myeloma measurable residual disease: identification of targets for precision medicine
Martina Zátopková, Tereza Ševčíková, Viola Fanfani, Zuzana Chyra, Lucie Rihova, Renata Bezdekova, David ŽIHALA, Kateřina Growková, Jana Filipová, Lucie Černá, Lucie Broskevicova, Fedor Kryukov, Jiri Minarik, Jana Smejkalova, Vladimir Maisnar, Lubica Harvanova, Ludek Pour, Alexandra Jungova, Tereza Popková, Julio Rodriguez Bago, Anjana Anilkumar Sithara, Matouš Hrdinka, Tomáš Jelínek, Michal Šimíček, Giovanni Stracquadanio, Roman Hájek ... other authors
Year: 2022, Blood Advances
journal article

Buněčná linie univerzálních T lymfocytů (UNITs)
Michal Šimíček, Serhiy Forostyak, Hana Piková, Piotr Celichowski, Michal Zahradníček
Year: 2021


Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis
Zuzana Kufová, Tereza Ševčíková, Petr Vojta, J. Puterova, L. Brozova, Kateřina Growková, Jana Filipová, Martina Zátopková, S. Grosicki, A. Barchnicka, W. Wiktor-Jedrzejczak, A. Waszczuk-Gajda, A. Jungova, A. Mikulasova, M. Hajduch, M. Mokrejs, L. Pour, M. Stork, L. Harvanova, M. Mistrik, G. Mikala, P. Robak, A. Czyz, J. Debski, L. Usnarska-Zubkiewicz, A. Jurczyszyn, L. Stejskal, G. Morgan, Fedor Kryukov, E. Budinska, Michal Šimíček, Tomáš Jelínek, Matouš Hrdinka, Roman Hájek ... other authors
Year: 2021, HAEMATOL-HEMATOL J
journal article

Selection, Expansion, and Unique Pretreatment of Allogeneic Human Natural Killer Cells with Anti-CD38 Monoclonal Antibody for Efficient Multiple Myeloma Treatment
Benjamin Motais, Sandra Charvátová, Zuzana Walek, Matouš Hrdinka, Ryszard Smolarczyk, Tomasz Cichoń, Justyna Czapla, Sebastian Giabel, Michal Šimíček, Tereza Ševčíková, Jiří Sobotka, Zdeněk Kořístek, Roman Hájek, Julio Rodriguez Bago ... other authors
Year: 2021, Cells
journal article

A Bird's-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers
Benjamin Motais, Sandra Charvátová, Matouš Hrdinka, Michal Šimíček, Tomáš Jelínek, Tereza Ševčíková, Zdeněk Kořístek, Roman Hájek, Julio Rodriguez Bago ... other authors
Year: 2020, CANCERS
journal article

Intercellular Mitochondrial Transfer in the Tumor Microenvironment
Hana Šahinbegović, Tomáš Jelínek, Matouš Hrdinka, Julio Rodriguez Bago, Marcello Turi, Tereza Ševčíková, Amina Kurtovic-Kotaric, Roman Hájek, Michal Šimíček ... other authors
Year: 2020, Cancers
journal article

Transcriptional profiling of circulating tumor cells in multiple myeloma: a new model to understand disease dissemination
Garces Juan-Jose, Michal Šimíček, Vicari Marco, Brozova Lucie, Burgos Leire, Bezdekova Renata, Alignani Diego, Calasanz Maria-Jose, Kateřina Growková, Goicoechea Ibai, Agirre Xabier, Pour Ludek, Prosper Felipe, Rios Rafael, Martinez-Lopez Joaquin, Millacoy Pamela, Palomera Luis, Del Orbe Rafael, Perez-Montana Albert, Garate Sonia, Blanco Laura, Lasa Marta, Maiso Patricia, Flores-Montero Juan, Sanoja-Flores Luzalba, Chyra Zuzana, Alexander Vdovin, Sevcikova Tereza, Tomáš Jelínek, Botta Cirino, El Omri Halima, Keats Jonathan, Orfao Alberto, Roman Hájek, San-Miguel Jesus F., Paiva Bruno ... other authors
Year: 2020, LEUKEMIA
journal article

Venetoclax plus bortezomib and dexamethasone in heavily pretreated end-stage myeloma patients without t(11;14): A real-world cohort
Tomáš Jelínek, Popkova Tereza, Juraj Ďuraš, Jana Fečková Mihályová, Michal Kaščák, Kateřina Benková, Plonkova Hana, Lucie Černá, Zdeněk Kořístek, Michal Šimíček, Roman Hájek ... other authors
Year: 2020, HEMATOLOGICAL ONCOLOGY
journal article

Cytarabine plus G-CSF is more effective than cyclophosphamide plus G-CSF as a stem cell mobilization regimen in multiple myeloma
Roman Hájek, Tomáš Jelínek, Lucie Adamusová, Tereza Popková, Jana Smejkalová, Michal Šimíček, Dana Salounová, Michal Kaščák, Jana Mihalyová, Hana Plonková, Juraj Ďuraš, Milan Navrátil, Zdeněk Kořístek ... other authors
Year: 2019, BONE MARROW TRANSPL
journal article

Single-agent venetoclax induces MRD-negative response in relapsed primary plasma cell leukemia with t(11;14)
Roman Hájek, Tomáš Jelínek, Jana Fečková Mihályová, Juraj Ďuraš, Tereza Popková, Kateřina Benková, Hana Plonková, Jana Zuchnická, Lucie Broskevičová, Lucie Huvarová, Lucie Černá, Kateřina Growková, Michal Šimíček, Martin Havel, Jaromír Gumulec, Zdeněk Kořístek, Bruno Paiva, Petra Richterová, Milan Navrátil, Michal Kascák ... other authors
Year: 2019, AMERICAN JOURNAL OF HEMATOLOGY
journal article

Active site alanine mutations convert deubiquitinases into high-affinity ubiquitinbinding proteins
Marie E Morrow, Michael T Morgan, Marcello Clerici, Kateřina Growková, Ming Yan, David Komander, Titia K Sixma, Michal Šimíček, Cynthia Wolberger ... other authors
Year: 2018, EMBO REP
journal article

Venetoclax: A new wave in hematooncology
Jana Fečková Mihályová, Tomáš Jelínek, K. Growková, Matouš Hrdinka, Michal Šimíček, Roman Hájek ... other authors
Year: 2018, EXPERIMENTAL HEMATOLOGY
journal article

Biomarkers in immunoglobulin light chain amyloidosis
Zuzana Kufová, Tereza Ševčíková, Kateřina Growková, P. Vojta, Jana Filipová, Z. Adam, L. Pour, M. Penka, R. Rysava, P. Nemec, L. Brozova, P. Vychytilova, A. Jurczyszyn, S. Grosicki, A. Barchnicka, M. Hajduch, Roman Hájek, Michal Šimíček ... other authors
Year: 2017, Klinicka Onkologie
journal article

CRISPR in research and treatment of multiple myeloma
Michal Šimíček, Kateřina Growková, Roman Hájek
Year: 2017, Klinicka Onkologie
journal article

Current applications of multiparameter flow cytometry in plasma cell disorders
Tomáš Jelínek, R. Bezdekova, R. Zatopkova, L. Burgos, Michal Šimíček, Tereza Ševčíková, B. Paiva, Roman Hájek ... other authors
Year: 2017, BLOOD CANCER JOURNAL
journal article

Whole exome sequencing of aberrant plasma cells in a patient with multiple myeloma minimal residual disease
M. Zatopkova, Jana Filipová, Tomáš Jelínek, Tereza Ševčíková, Michal Šimíček, L. Rihova, R. Bezdekova, Kateřina Growková, Zuzana Kufová, J. Smejkalova, M. Hajduch, L. Pour, J. Minarik, A. Jungova, V. Maisnar, Fedor Kryukov, Roman Hájek ... other authors
Year: 2017, Klinicka Onkologie
journal article

postdoktorská stáž
Michal Šimíček
Year: 2015
work experience abroad

doktorské studium
Michal Šimíček
Year: 2013
work experience abroad

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AuthorTitleType of thesisYear
Garbová NikolaIdentification of lateral interactions of CD19 partners using the PUP-IT methodMaster's thesis 2022 


Genetically modified donor T cells as a universal cell source for the immunotherapy of tumors using T lymphocytes equipped with a chimeric antigen receptor (CAR).
Main solverdoc. RNDr. Michal Šimíček, PhD.
Period8/2019 - 12/2022
ProviderProgram TRIO
Statesolved
Identification and functional validation of mutations in multiple myeloma patients resistant to therapy with proteasomal inhibitors
Main solverdoc. RNDr. Michal Šimíček, PhD.
Period1/2018 - 12/2020
ProviderKatedra interních oborů, MŠMT
Statefinished
Molecular characterization of newly identified protein markers in residual multiple myeloma resistant to antitumor therapy
Main solverdoc. RNDr. Michal Šimíček, PhD.
Period1/2019 - 12/2020
ProviderSpecifický VŠ výzkum
Statefinished
Organoid systems for modeling of bone marrow environment in the development of multiple myeloma
Main solverdoc. RNDr. Michal Šimíček, PhD.
Period1/2019 - 12/2020
ProviderSpecifický VŠ výzkum
Statefinished
Detection of new biomarkers in resistance to Venetoclax
Main solverdoc. RNDr. Michal Šimíček, PhD.
Period1/2018 - 12/2019
ProviderSpecifický VŠ výzkum
Statefinished
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