Science and Research

HNCRG research focuses on key processes that determine the behavior and clinical course of oral squamous cell carcinoma (OSCC) and related head and neck tumors. Our work bridges basic and applied research, using modern multi-omics approaches, 3D tumor models, and biomedical technologies. The group′s activities are built on four main pillars:

Immune Microenvironment and Therapeutic Targets in OSCC

We conduct comprehensive characterization of the tumor immune microenvironment and its influence on treatment response. We investigate the interplay of immune cells, stromal structures, and signaling pathways that affect the effectiveness of immunotherapy and the development of resistance. The aim is to identify predictive and therapeutically actionable factors enabling targeted and personalized treatment of patients.

Perineural Invasion and Neuro-tumor Signaling

We study the mechanisms by which tumor cells spread along nerve structures, a significant factor in local invasiveness and recurrence of OSCC. Our analyses integrate morphological, molecular, and microenvironmental aspects of this interaction and contribute to a deeper understanding of neurogenic signaling and its role in tumor progression. The acquired knowledge forms a basis for new diagnostic approaches and therapeutic strategies.

Microbiome and Host Interactions

Using modern multi-omics methods, we examine microbial components of the tumor microenvironment and their impact on immune and inflammatory processes in tissues. Our goal is to create an integrated "microbiome-host" model that will enable us to understand the role of functional dysbiosis in the onset and progression of head and neck cancers and support the development of new biomarkers and therapeutic approaches.

3D Models and Bioprinting of OSCC

We develop advanced three-dimensional models of the tumor microenvironment that realistically mimic biological processes occurring in tumors. Bioprinted models allow us to study invasiveness, perineural spread, immune interactions, and treatment response under controlled conditions. These experimental systems represent key tools for translational research and preclinical testing of new therapeutic strategies.

Updated: 18. 11. 2025