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Zuzana Chyra

Projects

Academic degree, name, surname:

Mgr. Zuzana Chyra, Ph.D.

Room, floor, building:

Position:

Research interests and teaching:

Department (Faculty):

Department of Haematooncology (Faculty of Medicine)
Medical Research Center (Faculty of Medicine)

Phone number, mobile:

E-mail:

No record found.

Beyond the marrow: insights from comprehensive nextgeneration sequencing of extramedullary multiple myeloma tumors

Tomáš Jelínek, David ŽIHALA, Tereza Ševčíková, Anjana Anilkumar Sithara, Veronika Kapustová, Hana Šahinbegović, Ondřej Venglář, Ludmila MUROŇOVÁ, Lucie Broskevičová, Serafim Nenarokov, Daniel Bílek, Tereza Popková, H. Plonková, Jan VRÁNA, Vladimír Židlík, Pavel Hurník, Martin Havel, Matouš Hrdinka, Zuzana Chyra, G. Stracquadanio, Michal Šimíček, Roman Hájek ... other authors

Year: 2024, Leukemia

journal article

Identification of disease-related aberrantly spliced transcripts in myeloma and strategies to target these alterations by RNA-based therapeutics

Daisuke Ogiya, Zuzana Chyra, Sigitas J. Verselis, Morgan OKeefe, Jacquelyn Cobb, Ivane Abiatari, Srikanth Talluri, Anjana Anilkumar Sithara, Teru Hideshima, Michael P. P. Chu, Roman Hájek, David M. Dorfman, Linda M. Pilarski, Kenneth C. Anderson, Sophia Adamia ... other authors

Year: 2023, BLOOD CANCER JOURNAL

journal article

Insight into the mechanism of CD34+ cell mobilisation impairment in multiple myeloma patients treated with anti-CD38 therapy

Ondřej Venglář, Veronika Kapustová, Anjana Anilkumar Sithara, David ŽIHALA, Ludmila MUROŇOVÁ, Tereza Ševčíková, Jan Vrana, Alexander Vdovin, Jakub Radocha, Petra Krhovska, Matouš Hrdinka, Michal Turjap, Tereza Popková, Zuzana Chyra, Lucie Broskevičová, Michal Šimíček, Zdeněk Kořístek, Roman Hájek, Tomáš Jelínek ... other authors

Year: 2023, BRITISH JOURNAL OF HAEMATOLOGY

journal article

More Than 2% of Circulating Tumor Plasma Cells Defines Plasma Cell Leukemia-Like Multiple Myeloma

Tomáš Jelínek, Renata Bezdekova, David ŽIHALA, Tereza Ševčíková, Anjana Anilkumar Sithara, Lenka Pospisilova, Sabina Sevcikova, Petra Polackova, Martin Stork, Zdenka Knechtova, Ondřej Venglář, Veronika Kapustová, Tereza Popková, Ludmila MUROŇOVÁ, Zuzana Chyra, Matouš Hrdinka, Michal Šimíček, Juan-Jose Garces, Noemi Puig, Maria-Teresa Cedena, Artur Jurczyszyn, Jorge J. Castillo, Miroslav Penka, Jakub Radocha, Maria Victoria Mateos, Jesus F. San-Miguel, Bruno Paiva, Ludek Pour, Lucie Rihova, Roman Hájek ... other authors

Year: 2023, JOURNAL OF CLINICAL ONCOLOGY

journal article

Transcriptome Analysis of Diffuse Large B-Cell Lymphoma Cells Inducibly Expressing MyD88 L265P Mutation Identifies Upregulated CD44, LGALS3, NFKBIZ, and BATF as Downstream Targets of Oncogenic NF-κB Signaling

Marcello Turi, Anjana Anilkumar Sithara, Lucie Hofmanová, David ŽIHALA, Dhwani Radhakrishnan, Alexander Vdovin, Sofija Knápková, Tereza Ševčíková, Zuzana Chyra, Tomáš Jelínek, Michal Šimíček, Annamaria Gulla, Kenneth Carl Anderson, Roman Hájek, Matouš Hrdinka ... other authors

Year: 2023, International Journal of Molecular Sciences

journal article

Tuning CARs: recent advances in modulating chimeric antigen receptor (CAR) T cell activity for improved safety, efficacy, and flexibility

Piotr Celichowski, Marcello Turi, Sandra Charvátová, Dhwani Radhakrishnan, Neda Feizi, Zuzana Chyra, Michal Šimíček, Tomáš Jelínek, Julio Rodriguez Bago, Roman Hájek, Matouš Hrdinka ... other authors

Year: 2023, Journal of Translational Medicine

journal article

""Molecular"" resection margins in squamous cell carcinoma of the oral cavity - report of the first results of the multidisciplinary view

Pavel Hurník, Jan Štembírek, Zuzana Chyra, Tereza Ševčíková, Jana Režnarová, B. Putnova, Zuzana Čermáková, Tomáš Blažek, Vladimír Židlík, Oldřich Res, J. Stransky, M. Buchtova ... other authors

Year: 2022

abstract in proceedings

Mutation landscape of multiple myeloma measurable residual disease: identification of targets for precision medicine

Martina Zátopková, Tereza Ševčíková, Viola Fanfani, Zuzana Chyra, Lucie Rihova, Renata Bezdekova, David ŽIHALA, Kateřina Growková, Jana Filipová, Lucie Černá, Lucie Broskevicova, Fedor Kryukov, Jiri Minarik, Jana Smejkalova, Vladimir Maisnar, Lubica Harvanova, Ludek Pour, Alexandra Jungova, Tereza Popková, Julio Rodriguez Bago, Anjana Anilkumar Sithara, Matouš Hrdinka, Tomáš Jelínek, Michal Šimíček, Giovanni Stracquadanio, Roman Hájek ... other authors

Year: 2022, Blood Advances

journal article

The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma

Alexander Vdovin, Tomáš Jelínek, David ŽIHALA, Tereza Ševčíková, Michal Ďurech, Hana Šahinbegović, Renáta Šnaurová, Dhwani Radhakrishnan, Marcello Turi, Zuzana Chyra, Tereza Popková, Ondřej Venglář, Matouš Hrdinka, Roman Hájek, Michal Šimíček ... other authors

Year: 2022, Nature Communications

journal article

Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis

Zuzana Kufová, Tereza Ševčíková, Petr Vojta, J. Puterova, L. Brozova, Kateřina Growková, Jana Filipová, Martina Zátopková, S. Grosicki, A. Barchnicka, W. Wiktor-Jedrzejczak, A. Waszczuk-Gajda, A. Jungova, A. Mikulasova, M. Hajduch, M. Mokrejs, L. Pour, M. Stork, L. Harvanova, M. Mistrik, G. Mikala, P. Robak, A. Czyz, J. Debski, L. Usnarska-Zubkiewicz, A. Jurczyszyn, L. Stejskal, G. Morgan, Fedor Kryukov, E. Budinska, Michal Šimíček, Tomáš Jelínek, Matouš Hrdinka, Roman Hájek ... other authors

Year: 2021, HAEMATOL-HEMATOL J

journal article

"Molecular" resection margins in squamous cell carcinoma of the orofacial region

J. Štembírek, Zuzana Chyra, B. Putnová, Z. Čermáková, Tereza Ševčíková, T. Blažek, P. Hurník, O. Res, J. Stránský, M. Buchtová ... other authors

Year: 2021

presentations (congresses, symposia, conferences, workshops)

Morphological study of HNSCC focused on perineural invasion - a single institutional study with five year follow up

Pavel Hurník, J. Štembírek, Tereza Ševčíková, Zuzana Chyra, B. Putnová, Z. Čermáková, M. Buchtová ... other authors

Year: 2021

presentations (congresses, symposia, conferences, workshops)

Newly designed 11-gene panel reveals first case of hereditary amyloidosis captured by massive parallel sequencing

Zuzana Kufová, Tereza Ševčíková, J. Januska, P. Vojta, A. Boday, P. Vanickova, Jana Filipová, Kateřina Growková, Tomáš Jelínek, M. Hajduch, Roman Hájek ... other authors

Year: 2018, JOURNAL OF CLINICAL PATHOLOGY

journal article

Biobanking strategy and sample preprocessing for integrative research in monoclonal gammopathies

Tereza Ševčíková, Kateřina Growková, Zuzana Kufová, Jana Filipová, P. Vrublová, Tomáš Jelínek, Zdeněk Kořístek, Fedor Kryukov, Elena Kryukova, Roman Hájek ... other authors

Year: 2017, JOURNAL OF CLINICAL PATHOLOGY

journal article

Biomarkers in immunoglobulin light chain amyloidosis

Zuzana Kufová, Tereza Ševčíková, Kateřina Growková, P. Vojta, Jana Filipová, Z. Adam, L. Pour, M. Penka, R. Rysava, P. Nemec, L. Brozova, P. Vychytilova, A. Jurczyszyn, S. Grosicki, A. Barchnicka, M. Hajduch, Roman Hájek, Michal Šimíček ... other authors

Year: 2017, Klinicka Onkologie

journal article

Diagnostic Tools of Waldenström's Macroglobulinemia - Best Possibilities for Non-invasive and Long-term Disease Monitoring

Kateřina Growková, Zuzana Kufová, Tereza Ševčíková, Jana Filipová, M. Kascak, Tomáš Jelínek, S. Grosicki, A. Barchnicka, L. Roziakova, M. Mistrik, M. Simicek, Roman Hájek ... other authors

Year: 2017, Klinická onkologie

journal article

Proteasome inhibitors in AL amyloidosis: focus on mechanismof action and clinical activity

Tomáš Jelínek, Elena Kryukova, Zuzana Kufová, Fedor Kryukov, Roman Hájek

Year: 2017, Hematological Oncology

journal article

The spectrum of somatic mutations in monoclonal gammopathy of undetermined significance indicates a less complex genomic landscape than that in multiple myeloma

A. Mikulasova, Ch. P. Wardell, A. Murison, E. M. Boyle, G. H. Jackson, J. Smetana, Zuzana Kufová, L. Pour, V. Sandecka, M. Almasi, P. Vsianska, E. Gregora, P. Kuglik, Roman Hájek, F. E. Davies, G. J. Morgan, B. A. Walker ... other authors

Year: 2017, HAEMATOLOGICA

journal article

Waldenström's macroglobulinemia: Two malignant clones in a monoclonal disease? Molecular background and clinical reflection

Kateřina Growková, Elena Kryukova, Zuzana Kufová, Jana Filipová, Tereza Ševčíková, L. Rihova, M. Kascak, Fedor Kryukov, Roman Hájek ... other authors

Year: 2017, EUROPEAN JOURNAL OF HAEMATOLOGY

journal article

Whole exome sequencing of aberrant plasma cells in a patient with multiple myeloma minimal residual disease

M. Zatopkova, Jana Filipová, Tomáš Jelínek, Tereza Ševčíková, Michal Šimíček, L. Rihova, R. Bezdekova, Kateřina Growková, Zuzana Kufová, J. Smejkalova, M. Hajduch, L. Pour, J. Minarik, A. Jungova, V. Maisnar, Fedor Kryukov, Roman Hájek ... other authors

Year: 2017, Klinicka Onkologie

journal article

Does AL amyloidosis have a unique genomic profile? Gene expression profiling meta-analysis and literature overview

Fedor Kryukov, Elena Kryukova, Lucie Brožová, Zuzana Kufová, Jana Filipová, Kateřina Growková, Tereza Ševčíková, Jiří Jarkovský, Roman Hájek ... other authors

Year: 2016, GENE

journal article

Genomewide profiling of copy-number alteration in monoclonal gammopathy of undetermined significance

Aneta Mikulášová, J. Smetana, M. Wayhelova, H. Janyskova, V. Sandecka, Zuzana Kufová, M. Almasi, J. Jarkovsky, E. Gregora, P. Kessler, M. Wrobel, B.A. Walker, CH. P. Wardell, G.J. Morgan, Roman Hájek, P. Kuglik ... other authors

Year: 2016, EUR J HAEMATOL

journal article

Immunomodulatory drugs in AL amyloidosis

Tomáš Jelínek, Zuzana Kufová, Roman Hájek

Year: 2016, CRIT REV ONCOL HEMAT

journal article

Waldenströmova makroglobulinémie v roce 2016: optimalizace imunochemoterapie s cílem minimalizace nežádoucích účinků

Michal Kaščák, Zuzana Kufová, Kateřina Growková, Roman Hájek

Year: 2016, Onkologia pre prax

journal article

Flow cytometry in immunoglobulin light chain amyloidosis: Short review

Jana Filipová, Lucie Řihová, Pavla Vsianská, Zuzana Kufová, Elena Kryukova, Fedor Kryukov, Roman Hájek ... other authors

Year: 2015, LEUKEMIA RES

journal article

Hereditární amyloidózy - etiologie, klinický obraz a léčba

Zuzana Kufová, T. Pika, T. Jelínek, Fedor Kryukov, Roman Hájek

Year: 2015, Transfuze a Hematologie Dnes

journal article

Detekce hereditárních amyloidóz

Zuzana Kufová, Zuzana Ševčíková, Roman Hájek

Year: 2014, Klinická biochemie a metabolismus

journal article

Diagnostika a léčba systémové AL amyloidózy

Vlastimil Ščudla, Zdeněk Adam, Roman Hájek, Marta Krejčí, Tomáš Pika, Vladimír Maisnar, Patrik Flodr, Zuzana KUFOVÁ, Pavla Látalová, Anna Potáčová, Romana Ryšavá, Ivan Špička, Martin Tichý, Pavla Všianská ... other authors

Year: 2013, Transfuze a hematologie dnes

journal article

No record found.

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Abbreviation

Subject

VL4LF

Vnitřní lékařství IV. - hem., trans.lék.

YVL4L

Internal medicine IV. - hematooncology

9VL4L

Vnitřní lékařství IV. - hem., trans.lék.

No record found.

Complex Panel for Monoclonal Gammopathies Genetic Screening

Main solver

Mgr. Zuzana Chyra, Ph.D.

Period

1/2024 - 6/2025

Provider

Technologická agentura ČR

State

solved

Waldenström's macroglobulinenmia and application of genomic screening

Main solver

Mgr. Zuzana Chyra, Ph.D.

Period

1/2016 - 12/2017

Provider

Specifický VŠ výzkum

State

finished

Screening of mutational states of hereditary amyloidosis in the Czech Republic

Main solver

Mgr. Zuzana Chyra, Ph.D.

Period

1/2014 - 12/2015

Provider

Specifický VŠ výzkum

State

finished

Zuzana Chyra

Basic information

CV

Publications

Teaching

Supervised theses

Projects

Blood Cancer Research Group