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UO > About > Organizational Structure > Faculties & Institutes > Faculty of Medicine > Departments & Centres > Centre for Health Research > Blood Cancer Research Group

Zuzana Chyra


Academic degree, name, surname:
Mgr. Zuzana Chyra, Ph.D.
Room, floor, building:
Position:
Research interests and teaching:
Department (Faculty):
Klinika hematoonkologie (Lékařská fakulta)
Blood Cancer Research Group (Lékařská fakulta)
Phone number, mobile:
E-mail:



No record found.



Deubiquitinase BAP1 is crucial for surface expression of T cell receptor (TCR) complex, T cell-B cell conjugate formation, and T cell activation
Dhwani Radhakrishnan, Jana Kotulová, Lucie Hofmanová, Anjana Anilkumar Sithara, Marcello Turi, David ŽIHALA, Michal Ďurech, Jan VRÁNA, Valeria Uleri, Veronika Niederlova, Stepanek Ondrej, Zuzana Chyra, Tomáš Jelínek, Roman Hájek, Matouš Hrdinka ... other authors
Year: 2025, Journal of Leukocyte Biology
journal article
 
Beyond the marrow: insights from comprehensive next-generation sequencing of extramedullary multiple myeloma tumors
Tomáš Jelínek, David ŽIHALA, Tereza Ševčíková, Anjana Anilkumar Sithara, Veronika Kapustová, Hana Šahinbegović, Ondřej Venglář, Ludmila MUROŇOVÁ, Lucie Broskevičová, Serafim Nenarokov, Daniel Bílek, Tereza Popková, H. Plonkova, Jan VRÁNA, V. Zidlik, P. Hurník, Martin Havel, Matouš Hrdinka, Zuzana Chyra, G. Stracquadanio, Michal Šimíček, Roman Hájek ... other authors
Year: 2024, LEUKEMIA
journal article
 
Beyond the marrow: insights from comprehensive nextgeneration sequencing of extramedullary multiple myeloma tumors
Tomáš Jelínek, David ŽIHALA, Tereza Ševčíková, Anjana Anilkumar Sithara, Veronika Kapustová, Hana Šahinbegović, Ondřej Venglář, Ludmila MUROŇOVÁ, Lucie Broskevičová, Serafim Nenarokov, Daniel Bílek, Tereza Popková, H. Plonková, Jan VRÁNA, Vladimír Židlík, Pavel Hurník, Martin Havel, Matouš Hrdinka, Zuzana Chyra, G. Stracquadanio, Michal Šimíček, Roman Hájek ... other authors
Year: 2024, Leukemia
journal article
 
Impact of T cell characteristics on CAR-T cell therapy in hematological malignancies
Zhongfei Tao, Zuzana Chyra, Jana Kotulová, Piotr Celichowski, Jana Fečková Mihályová, Sandra Charvátová, Roman Hájek ... other authors
Year: 2024, BLOOD CANCER JOURNAL
journal article
 
Insight into the mechanism of CD34+ cell mobilisation impairment in multiple myeloma patients treated with anti-CD38 therapy
Ondřej Venglář, Veronika Kapustová, Anjana Anilkumar Sithara, David ŽIHALA, Ludmila MUROŇOVÁ, Tereza Ševčíková, Jan Vrana, Alexander Vdovin, Jakub Radocha, Petra Krhovska, Matouš Hrdinka, Michal Turjap, Tereza Popková, Zuzana Chyra, Lucie Broskevičová, Michal Šimíček, Zdeněk Kořístek, Roman Hájek, Tomáš Jelínek ... other authors
Year: 2024, BRITISH JOURNAL OF HAEMATOLOGY
journal article
 
Identification of disease-related aberrantly spliced transcripts in myeloma and strategies to target these alterations by RNA-based therapeutics
Daisuke Ogiya, Zuzana Chyra, Sigitas J. Verselis, Morgan OKeefe, Jacquelyn Cobb, Ivane Abiatari, Srikanth Talluri, Anjana Anilkumar Sithara, Teru Hideshima, Michael P. P. Chu, Roman Hájek, David M. Dorfman, Linda M. Pilarski, Kenneth C. Anderson, Sophia Adamia ... other authors
Year: 2023, BLOOD CANCER JOURNAL
journal article
 
More Than 2% of Circulating Tumor Plasma Cells Defines Plasma Cell Leukemia-Like Multiple Myeloma
Tomáš Jelínek, Renata Bezdekova, David ŽIHALA, Tereza Ševčíková, Anjana Anilkumar Sithara, Lenka Pospisilova, Sabina Sevcikova, Petra Polackova, Martin Stork, Zdenka Knechtova, Ondřej Venglář, Veronika Kapustová, Tereza Popková, Ludmila MUROŇOVÁ, Zuzana Chyra, Matouš Hrdinka, Michal Šimíček, Juan-Jose Garces, Noemi Puig, Maria-Teresa Cedena, Artur Jurczyszyn, Jorge J. Castillo, Miroslav Penka, Jakub Radocha, Maria Victoria Mateos, Jesus F. San-Miguel, Bruno Paiva, Ludek Pour, Lucie Rihova, Roman Hájek ... other authors
Year: 2023, JOURNAL OF CLINICAL ONCOLOGY
journal article
 
Transcriptome Analysis of Diffuse Large B-Cell Lymphoma Cells Inducibly Expressing MyD88 L265P Mutation Identifies Upregulated CD44, LGALS3, NFKBIZ, and BATF as Downstream Targets of Oncogenic NF-κB Signaling
Marcello Turi, Anjana Anilkumar Sithara, Lucie Hofmanová, David ŽIHALA, Dhwani Radhakrishnan, Alexander Vdovin, Sofija Knápková, Tereza Ševčíková, Zuzana Chyra, Tomáš Jelínek, Michal Šimíček, Annamaria Gulla, Kenneth Carl Anderson, Roman Hájek, Matouš Hrdinka ... other authors
Year: 2023, International Journal of Molecular Sciences
journal article
 
Tuning CARs: recent advances in modulating chimeric antigen receptor (CAR) T cell activity for improved safety, efficacy, and flexibility
Piotr Celichowski, Marcello Turi, Sandra Charvátová, Dhwani Radhakrishnan, Neda Feizi, Zuzana Chyra, Michal Šimíček, Tomáš Jelínek, Julio Rodriguez Bago, Roman Hájek, Matouš Hrdinka ... other authors
Year: 2023, Journal of Translational Medicine
journal article
 
""Molecular"" resection margins in squamous cell carcinoma of the oral cavity - report of the first results of the multidisciplinary view
Pavel Hurník, Jan Štembírek, Zuzana Chyra, Tereza Ševčíková, Jana Režnarová, B. Putnova, Zuzana Čermáková, Tomáš Blažek, Vladimír Židlík, Oldřich Res, J. Stransky, M. Buchtova ... other authors
Year: 2022
abstract in proceedings
 
Mutation landscape of multiple myeloma measurable residual disease: identification of targets for precision medicine
Martina Zátopková, Tereza Ševčíková, Viola Fanfani, Zuzana Chyra, Lucie Rihova, Renata Bezdekova, David ŽIHALA, Kateřina Growková, Jana Filipová, Lucie Černá, Lucie Broskevicova, Fedor Kryukov, Jiri Minarik, Jana Smejkalova, Vladimir Maisnar, Lubica Harvanova, Ludek Pour, Alexandra Jungova, Tereza Popková, Julio Rodriguez Bago, Anjana Anilkumar Sithara, Matouš Hrdinka, Tomáš Jelínek, Michal Šimíček, Giovanni Stracquadanio, Roman Hájek ... other authors
Year: 2022, Blood Advances
journal article
 
The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma
Alexander Vdovin, Tomáš Jelínek, David ŽIHALA, Tereza Ševčíková, Michal Ďurech, Hana Šahinbegović, Renáta Šnaurová, Dhwani Radhakrishnan, Marcello Turi, Zuzana Chyra, Tereza Popková, Ondřej Venglář, Matouš Hrdinka, Roman Hájek, Michal Šimíček ... other authors
Year: 2022, Nature Communications
journal article
 
Heterogenous mutation spectrum and deregulated cellular pathways in aberrant plasma cells underline molecular pathology of light-chain amyloidosis
Zuzana Kufová, Tereza Ševčíková, Petr Vojta, J. Puterova, L. Brozova, Kateřina Growková, Jana Filipová, Martina Zátopková, S. Grosicki, A. Barchnicka, W. Wiktor-Jedrzejczak, A. Waszczuk-Gajda, A. Jungova, A. Mikulasova, M. Hajduch, M. Mokrejs, L. Pour, M. Stork, L. Harvanova, M. Mistrik, G. Mikala, P. Robak, A. Czyz, J. Debski, L. Usnarska-Zubkiewicz, A. Jurczyszyn, L. Stejskal, G. Morgan, Fedor Kryukov, E. Budinska, Michal Šimíček, Tomáš Jelínek, Matouš Hrdinka, Roman Hájek ... other authors
Year: 2021, HAEMATOL-HEMATOL J
journal article
 
"Molecular" resection margins in squamous cell carcinoma of the orofacial region
J. Štembírek, Zuzana Chyra, B. Putnová, Z. Čermáková, Tereza Ševčíková, T. Blažek, P. Hurník, O. Res, J. Stránský, M. Buchtová ... other authors
Year: 2021
presentations (congresses, symposia, conferences, workshops)
 
Morphological study of HNSCC focused on perineural invasion - a single institutional study with five year follow up
Pavel Hurník, J. Štembírek, Tereza Ševčíková, Zuzana Chyra, B. Putnová, Z. Čermáková, M. Buchtová ... other authors
Year: 2021
presentations (congresses, symposia, conferences, workshops)
 
Newly designed 11-gene panel reveals first case of hereditary amyloidosis captured by massive parallel sequencing
Zuzana Kufová, Tereza Ševčíková, J. Januska, P. Vojta, A. Boday, P. Vanickova, Jana Filipová, Kateřina Growková, Tomáš Jelínek, M. Hajduch, Roman Hájek ... other authors
Year: 2018, JOURNAL OF CLINICAL PATHOLOGY
journal article
 
Biobanking strategy and sample preprocessing for integrative research in monoclonal gammopathies
Tereza Ševčíková, Kateřina Growková, Zuzana Kufová, Jana Filipová, P. Vrublová, Tomáš Jelínek, Zdeněk Kořístek, Fedor Kryukov, Elena Kryukova, Roman Hájek ... other authors
Year: 2017, JOURNAL OF CLINICAL PATHOLOGY
journal article
 
Biomarkers in immunoglobulin light chain amyloidosis
Zuzana Kufová, Tereza Ševčíková, Kateřina Growková, P. Vojta, Jana Filipová, Z. Adam, L. Pour, M. Penka, R. Rysava, P. Nemec, L. Brozova, P. Vychytilova, A. Jurczyszyn, S. Grosicki, A. Barchnicka, M. Hajduch, Roman Hájek, Michal Šimíček ... other authors
Year: 2017, Klinicka Onkologie
journal article
 
Diagnostic Tools of Waldenström's Macroglobulinemia - Best Possibilities for Non-invasive and Long-term Disease Monitoring
Kateřina Growková, Zuzana Kufová, Tereza Ševčíková, Jana Filipová, M. Kascak, Tomáš Jelínek, S. Grosicki, A. Barchnicka, L. Roziakova, M. Mistrik, M. Simicek, Roman Hájek ... other authors
Year: 2017, Klinická onkologie
journal article
 
Proteasome inhibitors in AL amyloidosis: focus on mechanismof action and clinical activity
Tomáš Jelínek, Elena Kryukova, Zuzana Kufová, Fedor Kryukov, Roman Hájek
Year: 2017, Hematological Oncology
journal article
 
The spectrum of somatic mutations in monoclonal gammopathy of undetermined significance indicates a less complex genomic landscape than that in multiple myeloma
A. Mikulasova, Ch. P. Wardell, A. Murison, E. M. Boyle, G. H. Jackson, J. Smetana, Zuzana Kufová, L. Pour, V. Sandecka, M. Almasi, P. Vsianska, E. Gregora, P. Kuglik, Roman Hájek, F. E. Davies, G. J. Morgan, B. A. Walker ... other authors
Year: 2017, HAEMATOLOGICA
journal article
 
Waldenström's macroglobulinemia: Two malignant clones in a monoclonal disease? Molecular background and clinical reflection
Kateřina Growková, Elena Kryukova, Zuzana Kufová, Jana Filipová, Tereza Ševčíková, L. Rihova, M. Kascak, Fedor Kryukov, Roman Hájek ... other authors
Year: 2017, EUROPEAN JOURNAL OF HAEMATOLOGY
journal article
 
Whole exome sequencing of aberrant plasma cells in a patient with multiple myeloma minimal residual disease
M. Zatopkova, Jana Filipová, Tomáš Jelínek, Tereza Ševčíková, Michal Šimíček, L. Rihova, R. Bezdekova, Kateřina Growková, Zuzana Kufová, J. Smejkalova, M. Hajduch, L. Pour, J. Minarik, A. Jungova, V. Maisnar, Fedor Kryukov, Roman Hájek ... other authors
Year: 2017, Klinicka Onkologie
journal article
 
Does AL amyloidosis have a unique genomic profile? Gene expression profiling meta-analysis and literature overview
Fedor Kryukov, Elena Kryukova, Lucie Brožová, Zuzana Kufová, Jana Filipová, Kateřina Growková, Tereza Ševčíková, Jiří Jarkovský, Roman Hájek ... other authors
Year: 2016, GENE
journal article
 
Genomewide profiling of copy-number alteration in monoclonal gammopathy of undetermined significance
Aneta Mikulášová, J. Smetana, M. Wayhelova, H. Janyskova, V. Sandecka, Zuzana Kufová, M. Almasi, J. Jarkovsky, E. Gregora, P. Kessler, M. Wrobel, B.A. Walker, CH. P. Wardell, G.J. Morgan, Roman Hájek, P. Kuglik ... other authors
Year: 2016, EUR J HAEMATOL
journal article
 
Immunomodulatory drugs in AL amyloidosis
Tomáš Jelínek, Zuzana Kufová, Roman Hájek
Year: 2016, CRIT REV ONCOL HEMAT
journal article
 
Waldenströmova makroglobulinémie v roce 2016: optimalizace imunochemoterapie s cílem minimalizace nežádoucích účinků
Michal Kaščák, Zuzana Kufová, Kateřina Growková, Roman Hájek
Year: 2016, Onkologia pre prax
journal article
 
Flow cytometry in immunoglobulin light chain amyloidosis: Short review
Jana Filipová, Lucie Řihová, Pavla Vsianská, Zuzana Kufová, Elena Kryukova, Fedor Kryukov, Roman Hájek ... other authors
Year: 2015, LEUKEMIA RES
journal article
 
Hereditární amyloidózy - etiologie, klinický obraz a léčba
Zuzana Kufová, T. Pika, T. Jelínek, Fedor Kryukov, Roman Hájek
Year: 2015, Transfuze a Hematologie Dnes
journal article
 
Detekce hereditárních amyloidóz
Zuzana Kufová, Zuzana Ševčíková, Roman Hájek
Year: 2014, Klinická biochemie a metabolismus
journal article
 
Diagnostika a léčba systémové AL amyloidózy
Vlastimil Ščudla, Zdeněk Adam, Roman Hájek, Marta Krejčí, Tomáš Pika, Vladimír Maisnar, Patrik Flodr, Zuzana KUFOVÁ, Pavla Látalová, Anna Potáčová, Romana Ryšavá, Ivan Špička, Martin Tichý, Pavla Všianská ... other authors
Year: 2013, Transfuze a hematologie dnes
journal article
 

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Author
Title
Type of thesis
Year
Fantová Tereza
Functional Characterization of Aberrantly Expressed Proteins as Potential Therapeutical Targets in AL Amyloidosis
Master's thesis
2025



Complex Panel for Monoclonal Gammopathies Genetic Screening
Main solver
Mgr. Zuzana Chyra, Ph.D.
Period
1/2024 - 6/2025
Provider
Technologická agentura ČR
State
solved
 
Waldenström's macroglobulinenmia and application of genomic screening
Main solver
Mgr. Zuzana Chyra, Ph.D.
Period
1/2016 - 12/2017
Provider
Specifický VŠ výzkum
State
finished
 
Screening of mutational states of hereditary amyloidosis in the Czech Republic
Main solver
Mgr. Zuzana Chyra, Ph.D.
Period
1/2014 - 12/2015
Provider
Specifický VŠ výzkum
State
finished
 

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